Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (5): 608-612.doi: 10.3969/j.issn.1673-5749.2010.05.032

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Research progress of gene therapy on temporomandibular joint osteoarthrosis

YANG Bin, ZHANG Zhiguang.   

  1. Research Institute of Stomatology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou 510055, China
  • Online:2010-09-20 Published:2010-09-20

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Abstract:

Osteoarthrosis is a common degenerative articulation disease, which is characterized by cartilage injury. Conventional treatment of this disease is not satisfactory. Gene therapy becomes a new technique for the treatment of joint diseases in recent years. Temporomandibular joint is one of the most active synovial joints. It is in ongoing remolding after birth, which will meet to the demand of masticatory function at different age stages. The structure and function of this joint are significant to keep the balance of stomatognathic system. Although temporomandibular joint is small in size, it bears relatively heavy masticatory force. So it is more vulnerable to osteoarthrosis than other larger joints. This article is a brief review about the progress of target cells, candidate gene and vectors of gene therapy on temporomandibular joint osteoarthrosis.

Key words: temporomandibular joint, osteoarthrosis, gene therapy


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