国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (5): 677-683.doi: 10.7518/gjkq.2025053

• 综述 • 上一篇    下一篇

牙周炎与非酒精性脂肪性肝病相关性的研究进展

李欢1(),原韶钟1,2()   

  1. 1.山西医科大学口腔医学院 太原 030001
    2.山西医科大学附属山西省人民医院口腔内科 太原 030012
  • 收稿日期:2024-06-25 修回日期:2024-08-31 出版日期:2025-09-01 发布日期:2025-08-27
  • 通讯作者: 原韶钟
  • 作者简介:李欢，住院医师，硕士，Email：913314328@qq.com

Research progress on the relationship between periodontitis and non-alcoholic fatty liver disease

Huan Li1(),Shaozhong Yuan1,2()   

  1. 1.Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, China
    2.Dept. of Oral Medicine, Shanxi Provincial People’s Hospital, Shanxi Medical University, Taiyuan 030012, China
  • Received:2024-06-25 Revised:2024-08-31 Online:2025-09-01 Published:2025-08-27
  • Contact: Shaozhong Yuan

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摘要：

非酒精性脂肪性肝病（NAFLD）是一种以肝细胞脂肪堆积为特征的疾病，牙周炎是发生在牙齿支持组织的慢性炎症性疾病，已有研究发现两者密切相关，但对两者的相关机制尚不明确。越来越多的证据表明，牙周炎伴随着口腔炎症和微生物组的病理变化，诱导肠道生态失调，肠道微生物组的改变也可能在NAFLD的发病机制中发挥作用。本文将从NAFLD与牙周炎的流行病学、可能的相关机制、治疗等方面作一综述，期待从口腔医学视角为NAFLD的防治提供新思路。

关键词: 牙周炎, 非酒精性脂肪性肝病, 口腔-肠-肝轴, 牙龈卟啉单胞菌, 相关性

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by the accumulation of liver cell fat, and periodontitis is a chronic inflammation of the supporting tissues surrounding the teeth. Previous studies found a close correlation between NAFLD and periodontitis, but the interaction mechanisms are still unclear. Increasing evidence shows that periodontitis, accompanied by oral inflammation and pathological changes in the microbiome, induces intestinal dysbiosis, and changes in the intestinal microbiome may also play a role in the pathogenesis of NAFLD. This review will focus on the epidemiology, possible mechanisms, and treatment of NAFLD and periodontitis, expecting to provide a new NAFLD prevention strategy from a dental science viewpoint.

Key words: periodontitis, non-alcoholic fatty liver disease, oral-gut-liver axis, Porphyromonas gingivalis, correlation

中图分类号: 

  • R781.4
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