国际口腔医学杂志

国际口腔医学杂志 ›› 2026, Vol. 53 ›› Issue (4): 570-575.doi: 10.7518/gjkq.2026224

• 综述 • 上一篇    下一篇

石墨烯及其衍生物掺杂树脂粘接剂对口腔粘接界面力学和生物学性能影响的研究进展

陈文娣1(),李全利2()   

  1. 1.安徽省第二人民医院口腔科 合肥 230011
    2.深圳市龙岗区耳鼻咽喉医院口腔科 深圳 518172
  • 收稿日期:2025-01-24 修回日期:2025-10-10 出版日期:2026-07-01 发布日期:2026-06-25
  • 通讯作者: 李全利
  • 作者简介:陈文娣，主治医师，硕士，Email：cwdwendy@126.com
  • 基金资助:
    安徽高校自然科学研究重点项目(2022AH052323)

Research progress on the effects of resin adhesives doped with graphene and its derivatives on the mechanical and biological properties of dental adhesive interfaces

Wendi Chen1(),Quanli Li2()   

  1. 1.Dept. of Stomatology, Anhui No. 2 Provincial People’s Hospital, Hefei 230011, China
    2.Dept. of Stomatology, Longgang Otorhinolaryngology Hospital of Shenzhen, Shenzhen 518172, China
  • Received:2025-01-24 Revised:2025-10-10 Online:2026-07-01 Published:2026-06-25
  • Contact: Quanli Li
  • Supported by:
    Natural Science Research Project of Anhui Educational Committee(2022AH052323)

RichHTML

2

PDF (PC)

2

摘要：

以树脂粘接剂为基础的微创牙体修复技术是目前口腔医学牙体缺损修复最具特色的技术体系，临床成功的关键在于复合材料与牙体的粘接界面具有良好的耐久性。随着树脂粘接修复体暴露在口腔的时间延长，修复体逐渐出现边缘微渗漏，细菌及其产物进入导致继发龋。石墨烯及其衍生物因其独特结构和特殊性能引起国内外学者的关注，在口腔领域的应用也得到广泛研究。本文就石墨烯及其衍生物在口腔粘接领域的研究作一综述，对其在口腔粘接领域的应用进行讨论和总结。

关键词: 石墨烯, 石墨烯衍生物, 粘接

Abstract:

Minimally invasive dental restoration technology based on adhesive properties is a characteristic technology system for dental defect repair at present. The key to clinical success lies in the durability and stability of the resin-bonded interface between the composite material and the teeth. Given that the resin-bonded restorations are exposed to the mouth for an extended period, micro-leakage gradually appears at the edges of the restorations and bacteria and their products enter the prosthesis, which leads to secondary caries. Considering its peculiar structure and special properties, graphene and its derivatives have attracted the attention of scholars at home and abroad. Their applications in the field of stomatology have also been widely studied. In this study, we review the research on graphene and its derivatives in the field of dental bonding. Their applications in dental bonding are also discussed and summarized.

Key words: graphene, graphene derivatives, bonding

中图分类号: 

  • R781.05

表 1

石墨烯及其衍生物应用于口腔粘接剂的优点及局限性"

材料优点局限性
石墨烯高强度、高模量，提高粘接剂机械性能、抗菌性深色影响美观；易团聚，分散性差；潜在生物毒性争议
GO亲水性和分散性较好；可功能化修饰；提高粘接剂机械性能、抗菌性力学性能低于原始石墨烯；易团聚；含量过高影响粘接剂的聚合度
rGO保留部分官能团，可功能化修饰；抗菌性分散性差（需表面改性）；力学增强效果有限；颜色可能影响美观
FG抗菌性、潜在的再矿化能力（氟元素协同作用）生物相容性争议；疏水性强、分散性差
GNP提高粘接剂机械性能、抗菌性易团聚（需分散剂辅助）；深色问题仍存在
GQD尺寸小、分散性好；表面官能团丰富，易改性；光致发光性；提高粘接剂抗菌性和粘接耐久性合成工艺复杂，重复性差；长期生物安全性需验证
[1] Pashley DH, Tay FR, Breschi L, et al. State of the art etch-and-rinse adhesives[J]. Dent Mater, 2011, 27(1): 1-16.
[2] Breschi L, Mazzoni A, Ruggeri A, et al. Dental adhesion review: aging and stability of the bonded interface[J]. Dent Mater, 2008, 24(1): 90-101.
[3] 陈吉华, 肖玉鸿, 李芳. 牙科粘接材料抗菌改性的研究进展[J]. 中华口腔医学杂志, 2010, 45(8): 504-508.
Chen JH, Xiao YH, Li F. Research progress of antibacterial modification of dental adhesive materials [J]. Chin J Stomatol, 2010, 45(8): 504-508.
[4] Novoselov KS, Geim AK, Morozov SV, et al. Two-dimensional gas of massless Dirac fermions in graphene[J]. Nature, 2005, 438(7065): 197-200.
[5] Shulga NN, Shulga IS. Antibacterial properties of tea[J]. Eurasian Union Sci, 2020, 1(70): 31-33.
[6] Guazzo R, Gardin C, Bellin G, et al. Graphene-ba-sed nanomaterials for tissue engineering in the dental field[J]. Nanomaterials (Basel), 2018, 8(5): E349.
[7] Huang X, Qi XY, Boey F, et al. Graphene-based composites[J]. Chem Soc Rev, 2012, 41(2): 666-686.
[8] Sun C, Huang Y, Shen Q, et al. Embedding two-dimensional graphene array in ceramic matrix[J]. Sci Adv, 2020, 6: eabb1338.
[9] Lund S, Kauppila J, Sirkiä S, et al. Fast high-shear exfoliation of natural flake graphite with temperature control and high yield[J]. Carbon, 2021, 174: 123-131.
[10] Pereira R, Lins RBE, Lima EFS, et al. Properties of a dental adhesive containing graphene and DOPA-modified graphene[J]. Polymers (Basel), 2024, 16(14): 2081.
[11] Liu S, El-Angbawi A, Rosa V, et al. Physico-mechanical properties and bonding performance of graphene-added orthodontic adhesives[J]. J Funct Biomater, 2024, 15(8): 204.
[12] Aliyev E, Filiz V, Khan MM, et al. Structural cha-racterization of graphene oxide: surface functional groups and fractionated oxidative debris[J]. Nanomaterials, 2019, 9(8): 1180.
[13] Alshahrani A, Bin-Shuwaish MS, Al-Hamdan RS, et al. Graphene oxide nano-filler based experimental dentine adhesive. A SEM/EDX, micro-Raman and microtensile bond strength analysis[J]. J Appl Biomater Funct Mater, 2020, 18: 2280800020966936.
[14] Bin-Shuwaish MS, Maawadh AM, Al-Hamdan RS, et al. Influence of graphene oxide filler content on the dentin bond integrity, degree of conversion and bond strength of experimental adhesive. A SEM, micro-Raman, FTIR and microtensile study[J]. Mater Res Express, 2020, 7(11): 115403.
[15] Kim J, Yim BS, Kim JM, et al. The effects of functionalized graphene nanosheets on the thermal and mechanical properties of epoxy composites for ani-sotropic conductive adhesives (ACAs)[J]. Microelectron Reliab, 2012, 52(3): 595-602.
[16] Aguiar TR, de Oliveira M, Arrais CA, et al. The effect of photopolymerization on the degree of conversion, polymerization kinetic, biaxial flexure streng-th, and modulus of self-adhesive resin cements[J]. J Prosthet Dent, 2015, 113(2): 128-134.
[17] Khan AA, Al-Khureif AA, Saadaldin SA, et al. Graphene oxide-based experimental silane primers enhance shear bond strength between resin composite and zirconia[J]. Eur J Oral Sci, 2019, 127(6): 570-576.
[18] Almutairi B, Kattan HF, BinMahfooz AM, et al. Synergistic effect of graphene oxide/calcium phosphate nanofiller in a dentin adhesive on its dentin bond integrity and degree of conversion. A scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared, micro-Raman, and bond strength study[J]. Microsc Res Tech, 2021, 84(9): 2082-2094.
[19] AlFawaz YF, Almutairi B, Kattan HF, et al. Dentin bond integrity of hydroxyapatite containing resin adhesive enhanced with graphene oxide nano-particles-an SEM, EDX, micro-raman, and microtensile bond strength study[J]. Polymers (Basel), 2020, 12(12): E2978.
[20] Ilie N, Erich Serfözö N, Prodan D, et al. Synthesis and performance of experimental resin-based dental adhesives reinforced with functionalized graphene and hydroxyapatite fillers[J]. Mater Des, 2022, 221: 110985.
[21] Liu SB, Hu M, Zeng TH, et al. Lateral dimension-dependent antibacterial activity of graphene oxide sheets[J]. Langmuir, 2012, 28(33): 12364-12372.
[22] Pourhajibagher M, Bahador A. Orthodontic adhesive doped with nano-graphene oxide: physico-mechanical and antimicrobial properties[J]. Folia Med (Plovdiv), 2021, 63(3): 413-421.
[23] Pourhajibagher M, Ghorbanzadeh R, Salehi-Vaziri A, et al. In vitro assessments of antimicrobial potential and cytotoxicity activity of an orthodontic adhesive doped with nano-graphene oxide[J]. Folia Med (Plovdiv), 2022, 64(1): 110-116.
[24] Lee SM, Yoo KH, Yoon SY, et al. Enamel anti-demineralization effect of orthodontic adhesive containing bioactive glass and graphene oxide: an in-vitro study[J]. Materials, 2018, 11(9): 1728.
[25] Arslan S, Ekrikaya S, Ildiz N, et al. Evaluation of the antibacterial activity of dental adhesive containing biogenic silver nanoparticles decorated nanographene oxide nanocomposites (Ag@nGO NCs) and effect on bond strength to dentine[J]. Odontology, 2024, 112(2): 341-354.
[26] Dong Y, Li J, Yang XY. Reactions between graphene oxide sheets cause irreversible agglomeration[J]. Sci Bull (Beijing), 2022, 67(19): 1943-1945.
[27] Liao C, Li Y, Tjong SC. Graphene nanomaterials: synthesis, biocompatibility, and cytotoxicity[J]. Int J Mol Sci, 2018, 19(11): E3564.
[28] Yoon Y, Kye H, Yang WS, et al. Comparing graphene oxide and reduced graphene oxide as blen-ding materials for polysulfone and polyvinylidene difluoride membranes[J]. Appl Sci, 2020, 10(6): 2015.
[29] Alqarawi FK, Alkahtany MF, Almadi KH, et al. Influence of different conditioning treatments on the bond integrity of root dentin to rGO infiltrated dentin adhesive. SEM, EDX, FTIR and MicroRaman study[J]. Polymers (Basel), 2021, 13(10): 1555.
[30] Akram Z, Aati S, Clode P, et al. Formulation of nano-graphene doped with nano silver modified dentin bonding agents with enhanced interfacial stability and antibiofilm properties[J]. Dent Mater, 2022, 38(2): 347-362.
[31] Sheng Y, Zhou Y, Tang C, et al. Redispersible redu-ced graphene oxide prepared in a gradient solvent system[J]. Nanomaterials (Basel), 2022, 12(12): 1982.
[32] Bellier N, Baipaywad P, Ryu N, et al. Recent biomedical advancements in graphene oxide- and reduced graphene oxide-based nanocomposite nanocarriers[J]. Biomater Res, 2022, 26(1): 65.
[33] Lee SM, Yoo KH, Yoon SY, et al. Enamel anti-demineralization effect of orthodontic adhesive containing bioactive glass and graphene oxide: an in-vitro study[J]. Materials, 2018, 11(9): 1728.
[34] Hussein AH, Yassir YA. A novel graphite fluoride/bioactive glass-containing orthodontic primer with antibacterial and remineralization properties: an in-vitro study[J]. J Adhes Dent, 2024, 26: 253-262.
[35] Bregnocchi A, Zanni E, Uccelletti D, et al. Graphene-based dental adhesive with anti-biofilm acti-vity[J]. J Nanobiotechnology, 2017, 15(1): 89.
[36] Akram Z, Aati S, Shrestha B, et al. Silanization of nanographene platelets improves interaction with the dentin bonding resin matrix and enhances interfacial bond integrity to dentin[J]. Biomater Sci, 2021, 9(24): 8335-8346.
[37] Chen W, Jin HM, Zhang H, et al. Synergistic effects of graphene quantum dots and carbodiimide in promoting resin-dentin bond durability[J]. Dent Mater, 2021, 37(10): 1498-1510.
[38] Yin IX, Niu JY, Mei ML, et al. Tooth-binding graphene quantum dots silver nanocomposites for prevention of dental caries[J]. Int J Nanomedicine, 2024, 19: 11195-11212.
[39] Bae G, Cho H, Hong BH. A review on synthesis, properties, and biomedical applications of graphene quantum dots (GQDs)[J]. Nanotechnology, 2024, 35(37): 372001.
[1] 陈睿桢, 姜醒, 沈纪元, 林玲, 郑志强, 林捷. 牙体硬组织粘接界面抗酸碱层的研究进展[J]. 国际口腔医学杂志, 2025, 52(6): 722-729.
[2] 杨永杰,昭日格图. 受唾液污染玻璃陶瓷修复体不同清洁方式的研究进展[J]. 国际口腔医学杂志, 2025, 52(4): 443-448.
[3] 姚雪敏,王华,王璐,赵彬. 口腔半透明氧化锆陶瓷粘接效果的影响因素[J]. 国际口腔医学杂志, 2024, 51(4): 450-455.
[4] 吴礼安. 部分断冠粘接术在儿童恒前牙复杂冠根折中的初步应用[J]. 国际口腔医学杂志, 2023, 50(6): 623-631.
[5] 薛晶, 杨静. 基于循证实践的Ⅱ类洞复合树脂修复的操作要点[J]. 国际口腔医学杂志, 2023, 50(4): 375-387.
[6] 丁景瑜,田子璐,王惠敏,朱轩言,杨宇斌,朱松. 即刻牙本质封闭的研究进展[J]. 国际口腔医学杂志, 2022, 49(1): 121-124.
[7] 王剑. 浅谈嵌体和高嵌体修复的临床应用[J]. 国际口腔医学杂志, 2021, 48(5): 497-505.
[8] 刘昱晨,田敏,牛丽娜,方明. 粘接固定桥存留率的影响因素及提高对策[J]. 国际口腔医学杂志, 2021, 48(5): 585-591.
[9] 黎敏,华成舸,蒋丽. 提高氧化锆陶瓷粘接性能新技术的研究进展[J]. 国际口腔医学杂志, 2021, 48(4): 485-490.
[10] 钮晔,曾芸婷,曾悦翔,张泽宇,肖立伟. 数字化技术在直丝弓托槽间接粘接中的应用[J]. 国际口腔医学杂志, 2021, 48(4): 491-496.
[11] 沈冬妮,施莹,傅柏平. 后牙牙合贴面修复的研究进展[J]. 国际口腔医学杂志, 2021, 48(3): 287-291.
[12] 刘敏,张宽收,刘青梅. 激光蚀刻牙体组织在直接粘接技术中的研究进展[J]. 国际口腔医学杂志, 2021, 48(3): 292-296.
[13] 刘恩言,李明云. 茶多酚类化合物在牙本质粘接中应用的研究进展[J]. 国际口腔医学杂志, 2020, 47(6): 732-738.
[14] 韩雨亭,吴燕茹. 应用龈壁提升术修复牙体缺损的研究进展[J]. 国际口腔医学杂志, 2019, 46(3): 349-355.
[15] 秦娇娇,焦珊,王成坤. Er:YAG和Nd:YAG激光对牙本质与瓷修复体粘接面粘接强度影响的研究进展[J]. 国际口腔医学杂志, 2019, 46(3): 361-366.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!