Int J Stomatol ›› 2022, Vol. 49 ›› Issue (4): 397-403.doi: 10.7518/gjkq.2022074

• Oral Microbiology • Previous Articles     Next Articles

Research progress on the role of Porphyromonas gingivalis on promoting the development of Alzheimer ’ s disease

Wang Guanru(),Feng Qiang.()   

  1. Dept. of Human Microbiome, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory of Dental Materials and Oral Tissue Regeneration, Jinan 250012, China
  • Received:2021-10-12 Revised:2022-03-16 Online:2022-07-01 Published:2022-06-28
  • Contact: Qiang. Feng;


Periodontitis is an oral disease with high incidence in middle-aged and elderly individuals. It is also closely related to the increased risk of Alzheimer ’ s disease. Recent studies suggest that Porphyromonas gingivalis (P. gingivalis), the main pathogen of periodontitis, may be one of the pathogenic factors for Alzheimer ’ s disease. The DNA or specific antibodies of P. gingivalis can be detected in the cerebrospinal fluid or serum of patients with Alzheimer ’ s disease. Animal experiments showed that P. gingivalis or its toxic factors, such as lipopolysaccharide, gingival protease and peptidyl arginine deiminase, could reduce the learning and memory ability of mice. P. gingivalis could interfere with the host immune function by releasing a variety of inflammatory mediators, which cause a series of immune inflammatory reactions and destroy the function of host nerve cells. This study systematically reviewed the recent progress of P. gingivalis in the aetiology of Alzheimer ’ s disease to lay a foundation for comprehensively understanding the pathogenesis of Alzheimer ’ s disease.

Key words: Porphyromonas gingivalis, Alzheimer ’ s disease, pathogenesis

CLC Number: 

  • R 782


Fig 1

Potential mechanism of P. gingivalis promoting the occurrence and development of AD"

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