Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (4): 445-448.doi: 10.7518/gjkq.2016.04.016

Previous Articles     Next Articles

Mechanism and treatment of bisphosphonate-related osteonecrosis of the jaw

Wei Bin, Sun Guowen   

  1. Dept. of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, The Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing 210008, China
  • Online:2016-07-01 Published:2016-07-01

RichHTML

23

PDF (PC)

1057

Abstract: Bisphosphonate-related osteonecrosis of the jaw(BRONJ) is a severe complication that occurs frequently in patients subjected to long-term bisphosphonate treatment for osteoporosis, multiple myeloma, and other skeletal-related events induced by metastatic malignant diseases, such as breast, prostate, and lung cancers. The development of BRONJ is associated with some risk factors, such as bisphosphonate potency and administration model, dental extraction, and poorfitting dentures. The definition, staging, and treatment guidelines of patients with BRONJ were established by the American Association of Oral and Maxillofacial Surgeons in 2007 and then updated in 2009 and 2014. Although BRONJ has been extensively investigated, the pathogenesis of this disease has yet to be fully elucidated, and corresponding treatments have remained controversial. This article briefly introduces new insights into the pathogenesis and treatments of BRONJ.

Key words: bisphosphonate, bisphosphonate-related of osteonecrosis of the jaw, pathogenesis, treatment measures


TrendMD: 
[1] Xia Weiyao,Jia Zhonglin. Research progress on the relationship between vitamin and oral clefts [J]. Int J Stomatol, 2023, 50(6): 632-638.
[2] Wang Guanru,Feng Qiang.. Research progress on the role of Porphyromonas gingivalis on promoting the development of Alzheimer ’ s disease [J]. Int J Stomatol, 2022, 49(4): 397-403.
[3] Ji Xiao,Zhu Guiquan.. Research progress on the relationship between vitamin D and medication-related osteonecrosis of the jaw [J]. Int J Stomatol, 2022, 49(4): 441-447.
[4] Lei Bin,Chen Ke. Classification and treatment of dentin dysplasia type Ⅰ [J]. Int J Stomatol, 2022, 49(3): 332-336.
[5] Fu Zhuohui,Tan Xuelian,Huang Dingming. Diagnosis and treatment of odontogenic maxillary sinusitis [J]. Int J Stomatol, 2021, 48(3): 367-372.
[6] Guo Zhiyong,Liu Jiyuan,Li Chunjie,Tang Xiufa. Research progress on the pathogenesis of medication-related osteonecrosis of the jaw [J]. Int J Stomatol, 2020, 47(6): 717-724.
[7] Zhou Yuxi,Yong Xiangzhi,Jiang Qiaozhi,Tao Renchuan. Oral chronic graft versus host disease [J]. Int J Stomatol, 2019, 46(5): 609-616.
[8] Zheng Zhi, Yan Shiguo. Relationship between herpes virus and periodontitis [J]. Inter J Stomatol, 2018, 45(2): 224-227.
[9] Zhang Feng, Ouyang Shaobo, Liao Lan. Research progress on the pathogenesis of non-syndromic tooth agenesis [J]. Inter J Stomatol, 2018, 45(2): 219-223.
[10] Cheng Xingqun, Xu Xin, Zhou Xuedong, Li Yuqing.. Research progress on cyclic di-adenosine monophosphate signaling system and its potential role in oral bacterial pathogenesis [J]. Inter J Stomatol, 2017, 44(6): 647-653.
[11] Su Cheng, Wang Zekun, Luo Nanyu, Tang Hua.. Research progress on medication-related osteonecrosis of the jaw [J]. Inter J Stomatol, 2017, 44(2): 228-234.
[12] Li Sijie1, Xiao Xue2, Zhao Wei1. Research progress on the pathogenesis of ectodermal dysplasia syndrome [J]. Inter J Stomatol, 2017, 44(2): 244-248.
[13] Dai Qingyun, Cui Yuan, Feng Hui, Jiang Lu. Research progress on the etiology and pathogenesis of burning mouth syndrome [J]. Inter J Stomatol, 2015, 42(1): 54-58.
[14] Yan Xiujuan, Wu Xiaoguang, Xi Hong, Wang Ke, Li Yi.. Effect and mechanism of bisphosphonates on alveolar bone resorption [J]. Inter J Stomatol, 2014, 41(4): 424-426.
[15] Su Meiying1, Shi Bin1, 2, Zhang Yufeng1, 2.. Influence of bisphosphonates on dental implants [J]. Inter J Stomatol, 2013, 40(5): 653-656.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .