Int J Stomatol ›› 2022, Vol. 49 ›› Issue (2): 212-219.doi: 10.7518/gjkq.2022028

• Reviews • Previous Articles     Next Articles

Research progress of salivary proteins as predictive biomarkers for early childhood caries

Zhu Jinyi(),Fan Qi,Zhou Yuan,Zou Jing,Huang Ruijie()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-07-11 Revised:2021-11-20 Online:2022-03-01 Published:2022-03-15
  • Contact: Ruijie Huang;
  • Supported by:
    Science and Technology Project Fund of the Health Planning Committee of Sichuan Province(19PJ074)


The rapid progress of early childhood caries (ECC) and difficulty in early diagnosis have seriously affected the physical and mental health of children. Therefore, early prediction and preventive intervention for children at high risk are effective ways to control the disease. With the development of proteomics technology, salivary proteins are showing strong advantages for disease prediction and early diagnosis. Recent studies have shown that salivary proteins regulate the oral microecological environment through a variety of natural defense mechanisms and play an important role in ECC prevention. Salivary protein levels are associated with the host’s susceptibility to dental caries and are a potential predictor for caries risk. This review summarizes the mechanism of how different salivary proteins, including antimicrobial peptides, glycoproteins, enzymes, and immunoglobulins, influence ECC, as well as the research progress of how salivary proteins are used in disease prediction as biomarkers. On this basis, the application of salivary proteins in ECC risk assessment was prospected.

Key words: early childhood caries, salivary proteins, dental caries susceptibility, biomarkers

CLC Number: 

  • R780.1

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