Int J Stomatol ›› 2020, Vol. 47 ›› Issue (1): 102-108.doi: 10.7518/gjkq.2020012

• Reviews • Previous Articles     Next Articles

Research progress on oral microorganisms affect Alzheimer’s disease

Zhang Mingshuang1,2,Ba Te2,Wang Wenbiao1,2,()   

  1. 1. College of Stomatology, Weifang Medical University, Weifang 261000, China
    2. Dept. of Oral Surgery, Aviation General Hospital, Beijing 100020, China
  • Received:2019-04-12 Revised:2019-08-01 Online:2020-01-01 Published:2020-01-01
  • Contact: Wenbiao Wang
  • Supported by:
    This study was supported by Program for Science and Technology Projects in Beijing Chaoyang District(CYSF1724)


Oral microorganisms such as bacteria and fungi can cause a series of oral diseases, including caries and periodontitis. Some oral pathogens can cause systemic inflammation by secreting metabolites into the blood. Alzheimer’s disease (AD), a neurodegenerative disease, is the most common form of dementia. According to the World Health Organization, AD accounts for 60%-70% of dementia cases. With its morbidity increasing annually, AD has become one of the world’s most difficult problems. Amyloid β-protein (Aβ) deposition, hyperphosphorylation of tau protein, and loss of neurons with glial cell proliferation have been found in the brains of patients with AD. However, the pathogenesis of AD has not been elucidated. Recent studies reported that some oral microorganisms causing chronic periodontitis had become a significant risk factor for Aβ deposition and AD. Therefore, this article reviews the relationship between oral microorganisms and potential pathogenesis of AD.

Key words: Alzheimer’s disease, oral microorganism, Porphyromonas gingivalis, amyloid β-protein

CLC Number: 

  • R37

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