Int J Stomatol ›› 2019, Vol. 46 ›› Issue (3): 333-338.doi: 10.7518/gjkq.2019012

• Reviews • Previous Articles     Next Articles

Research progress on the risk factors of median rhomboid glossitis

Yilong Hao,Yu Zhou(),Qianming Chen   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-09-26 Revised:2019-01-12 Online:2019-05-01 Published:2019-06-05
  • Contact: Yu Zhou
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81621002);This study was supported by National Natural Science Foundation of China(81771086);This study was supported by National Natural Science Foundation of China(81470747)


Median rhomboid glossitis (MRG) is a type of tongue disease characterized by shiny oval or diamond-shaped erythematous areas on the dorsal midline of the tongue. The etiological factors of MRG remain unclear. Several possible risk factors cited in the literature include developmental anomalies, candidiasis, smoking, diabetes mellitus, denture wearing, and nutritional factors. Increasing evidence suggests that MRG is strongly associated with chronic candidal infection. Antifungal treatment is usually clinically effective. However, more studies are required to explore how candidiasis causes MRG. The objective of this review is to summarize current research on the risk factors of this tongue disease.

Key words: median rhomboid glossitis, Candida albicans infection, risk factors, therapy

CLC Number: 

  • R781.5


Fig 1

A diagram of the diagnosis and treatment of MRG"

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