Int J Stomatol

Inter J Stomatol ›› 2017, Vol. 44 ›› Issue (5): 514-518.doi: 10.7518/gjkq.2017.05.004

• Periodontitis • Previous Articles     Next Articles

Research progress on the correlation between chronic periodontitis and neurodegenerative diseases

Li Lin1, 2, Wang Dan1, Zhao Manzhu3, Tang Ming1   

  1. 1. Dept. of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;
    2. Sharedent Clinic, Chongqing 400016, China;
    3. Dept. of Preventive Dentistry, The Stomatological Hospital Affiliated to Chongqing Medical University, Chongqing 400016, China
  • Received:2017-03-07 Revised:2017-06-22 Online:2017-09-01 Published:2017-09-01

RichHTML

6

PDF (PC)

398

Abstract: Neurodegenerative diseases mainly encompass Alzheimer’s disease(AD), Parkinson’s disease(PD), Huntington’s disease(HD) and etc, characterized by progressive movement disorder, sensory disturbance and cognitive dysfunctin, which mostly develop in the elderly and there is no effective cure measures. Accumulating researches have demonstrated that neuroinflammation, systemic inflammationand immune disorder may be involved in onset and development of the diseases. Studies have shown that as a local bacterial infectious disease, chronic periodontitis possibly affect neurodegenerative diseases by periodontal pathogens, inflammatory mediators and oxidative stress. This review focuses on the correlation between chronic periodontitis and neurodegenerative diseases, for providing a new idea for prevention and treatment of neurodegenerative diseases.

Key words: chronic periodontitis, periodontal bacteria, neurodegenerative disease, neuroinflammation, immunity

CLC Number: 

  • R781.4

TrendMD: 
[1] Mulak A, Bonaz B. Brain-gut-microbiota axis in Par-kinson’s disease[J]. World J Gastroenterol, 2015, 21 (37):10609-10620.
[2] Hajishengallis G. Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response [J]. Trends Immunol, 2014, 35(1):3-11.
[3] Ide M, Harris M, Stevens A, et al. Periodontitis and cognitive decline in Alzheimer’s disease[J]. PLoS One, 2016, 11(3):e0151081.
[4] Joseph BK, Kullman L, Sharma PN. The oral-systemic disease connection: a retrospective study[J]. Clin Oral Investig, 2016, 20(8):2267-2273.
[5] Chapple IL, Milward MR, Dietrich T. The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations[J]. J Nutr, 2007, 137(3):657-664.
[6] 齐小秋. 第三次全国口腔健康流行病学调查报告[M]. 北京: 人民卫生出版社, 2008:60-102.
Qi XQ. The third national oral health epidemiologi-cal survey report[M]. Beijing: People’s Medical Pub-lishing House, 2008:60-102.
[7] Hollister EB, Gao C, Versalovic J. Compositional and functional features of the gastrointestinal microbiome and their effects on human health[J]. Gastroentero-logy, 2014, 146(6):1449-1458.
[8] Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation[J]. Nat Rev Im-munol, 2015, 15(1):30-44.
[9] Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets[J]. Periodontol 2000, 2002, 28: 12-55.
[10] Bensley L, VanEenwyk J, Ossiander EM. Associations of self-reported periodontal disease with metabolic syndrome and number of self-reported chronic con-ditions[J]. Prev Chronic Dis, 2011, 8(3):A50.
[11] Dye BA, Herrera-Abreu M, Lerche-Sehm J, et al. Serum antibodies to periodontal bacteria as diagnostic markers of periodontitis[J]. J Periodontol, 2009, 80 (4):634-647.
[12] Wu Z, Nakanishi H. Connection between periodonti-tis and Alzheimer’s disease: possible roles of micro-glia and leptomeningeal cells[J]. J Pharmacol Sci, 2014, 126(1):8-13.
[13] Kamer AR, Craig RG, Dasanayake AP, et al. Inflam-mation and Alzheimer’s disease: possible role of perio-dontal diseases[J]. Alzheimers Dement, 2008, 4(4): 242-250.
[14] Belstrøm D, Holmstrup P, Damgaard C, et al. The atherogenic bacterium Porphyromonas gingivalis evades circulating phagocytes by adhering to erythro-cytes[J]. Infect Immun, 2011, 79(4):1559-1565.
[15] Lakio L, Antinheimo J, Paju S, et al. Tracking of plasma antibodies against Aggregatibacter actinomy-cetemcomitans and Porphyromonas gingivalis during 15 years[J]. J Oral Microbiol, 2009, 1:10.3402/jom.-v1i0.1979.
[16] Poole S, Singhrao SK, Kesavalu L, et al. Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer’s disease brain tissue[J]. J Alzheimers Dis, 2013, 36(4):665-677.
[17] Tomás I, Alvarez M, Limeres J, et al. Prevalence, du-ration and aetiology of bacteraemia following dental extractions[J]. Oral Dis, 2007, 13(1):56-62.
[18] Forner L, Larsen T, Kilian M, et al. Incidence of ba-cteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation[J]. J Clin Periodontol, 2006, 33(6):401-407.
[19] Ferrari CC, Tarelli R. Parkinson’s disease and systemic inflammation[J]. Parkinsons Dis, 2011, 2011:436813.
[20] Liu Y, Wu Z, Zhang X, et al. Leptomeningeal cells transduce peripheral macrophages inflammatory sig-nal to microglia in reponse to Porphyromonas gingi-valis LPS[J]. Mediators Inflamm, 2013, 2013:407562.
[21] Appel SH, Beers DR, Henkel JS. T cell-microglial dialogue in Parkinson’s disease and amyotrophic lateral sclerosis: are we listening[J]. Trends Immunol, 2010, 31(1):7-17.
[22] Beers DR, Zhao W, Liao B, et al. Neuroinflammation modulates distinct regional and temporal clinical res-ponses in ALS mice[J]. Brain Behav Immun, 2011, 25(5):1025-1035.
[23] Lee JW, Lee YK, Yuk DY, et al. Neuro-inflammation induced by lipopolysaccharide causes cognitive im-pairment through enhancement of beta-amyloid ge-neration[J]. J Neuroinflammation, 2008, 5:37.
[24] Püntener U, Booth SG, Perry VH, et al. Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia[J]. J Neuroinflammation, 2012, 9:146.
[25] Montgomery SL, Bowers WJ. Tumor necrosis factor-alpha and the roles it plays in homeostatic and degene-rative processes within the central nervous system[J]. J Neuroimmune Pharmacol, 2012, 7(1):42-59.
[26] Bhaskar K, Maphis N, Xu G, et al. Microglial derived tumor necrosis factor-α drives Alzheimer’s disease-related neuronal cell cycle events[J]. Neurobiol Dis, 2014, 62:273-285.
[27] Sparks Stein P, Steffen MJ, Smith C, et al. Serum antibodies to periodontal pathogens are a risk factor for Alzheimer’s disease[J]. Alzheimers Dement, 2012, 8(3):196-203.
[28] Riviere GR, Riviere KH, Smith KS. Molecular and immunological evidence of oral Treponema in the hu-man brain and their association with Alzheimer’s disease [J]. Oral Microbiol Immunol, 2002, 17(2):113-118.
[29] Noble JM, Scarmeas N, Celenti RS, et al. Serum IgG antibody levels to periodontal microbiota are asso-ciated with incident Alzheimer disease[J]. PLoS One, 2014, 9(12):e114959.
[30] Farhad SZ, Amini S, Khalilian A, et al. The effect of chronic periodontitis on serum levels of tumor necro-sis factor-alpha in Alzheimer disease[J]. Dent Res J (Isfahan), 2014, 11(5):549-552.
[31] Gil-Montoya JA, Sanchez-Lara I, Carnero-Pardo C, et al. Is periodontitis a risk factor for cognitive im-pairment and dementia? A case-control study[J]. J Periodontol, 2015, 86(2):244-253.
[32] Engelborghs S, Gilles C, Ivanoiu A, et al. Rationale and clinical data supporting nutritional intervention in Alzheimer’s disease[J]. Acta ClinBelg, 2014, 69(1): 17-24.
[33] Noble JM, Borrell LN, Papapanou PN, et al. Perio-dontitis is associated with cognitive impairment among older adults: analysis of NHANES-Ⅲ[J]. J Neurol Neurosurg Psychiatry, 2009, 80(11):1206-1211.
[34] Einarsdóttir ER, Gunnsteinsdóttir H, Hallsdóttir MH, et al. Dental health of patients with Parkinson’s dis-ease in Iceland[J]. Spec Care Dentist, 2009, 29(3): 123-127.
[35] Herrera AJ, Castaño A, Venero JL, et al. The single intranigral injection of LPS as a new model for stu-dying the selective effects of inflammatory reactions on dopaminergic system[J]. Neurobiol Dis, 2000, 7 (4):429-447.
[36] Chen H, Zhang SM, Hernán MA, et al. Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease[J]. Arch Neurol, 2003, 60(8):1059-1064.
[1] Gong Meiling,Cheng Xingqun,Wu Hongkun.. Research progress on the correlation between Parkinson’s disease and periodontitis [J]. Int J Stomatol, 2023, 50(5): 587-593.
[2] Yang Xiaoyu,Yuan Quan.. Research progress on the role of extravascular fibrinogen deposition in mucosal diseases [J]. Int J Stomatol, 2023, 50(4): 457-462.
[3] Ye Yulin,Jiang Liting,Gao Yiming.. Role of autophagy in salivary glands of Sjögren’s syndrome [J]. Int J Stomatol, 2022, 49(5): 556-560.
[4] Qi Xiaoling,Gan Tingbin,Huang Jiao. Research progress on the relationship between chronic periodontitis and chronic kidney disease [J]. Int J Stomatol, 2021, 48(1): 18-22.
[5] Yuan Zhenying,Guan Cuiqiang,Nan Xinrong. Research progress on DNA methylation and oral disease [J]. Int J Stomatol, 2019, 46(4): 437-441.
[6] Yao Wang,Huixin Lü,Liuyi Du,Xinming Gu,Jingyi Ren,Weixian Yu,Yanmin Zhou. Roles of leptomeninges in the effect of chronic peripheral inflammation on neuroinflammation [J]. Inter J Stomatol, 2019, 46(2): 223-227.
[7] Huang Haixia, Lan Yuyan, Zhang Hao, Pan Lanlan, Guo Ling, Liu Min. Changes on periodontal index and inflammatory factor levels in gingival crevicular fluid after implant restoration in patients with chronic periodontitis [J]. Inter J Stomatol, 2018, 45(4): 396-402.
[8] Yang Chunyan, Shui Yanqing. Research progress on association between single nucleotide polymorphism and chronic periodontitis [J]. Inter J Stomatol, 2017, 44(4): 452-458.
[9] Zhao Hong, Wang Xinlin, Lü Zhi, Wang Dongqing, Su Jianrong. Microbiological community analysis by high-throughput sequencing of subgingival plaque in patients with chronic periodontitis before and after subgingival scaling and root planing [J]. Inter J Stomatol, 2017, 44(3): 294-300.
[10] Liu Qiong, Xie Hao, Sun Jiang. Comparison of clinical effects in ultrasonic system and periodontal flap surgery in a short time [J]. Inter J Stomatol, 2016, 43(2): 159-164.
[11] Wang Cancan, Yuan Hongmei, Chen Wen. Application of periodontal endoscope and nursing in perioscopy [J]. Inter J Stomatol, 2016, 43(2): 134-136.
[12] Sun Han, Hou Xu, Yu Wenwen, Qi Jia, Liu Jiming, Lou Yixin, Sun Xinhua.. Advancement of the role of Toll-like receptors in bone reconstruction [J]. Inter J Stomatol, 2015, 42(4): 450-452.
[13] Wang Xiaxia, Sun Hongying. Hypoxia-inducible factor-1α and oral lichen planus [J]. Inter J Stomatol, 2015, 42(3): 318-322.
[14] Tao Chuansibo, Mei Fang, Zhong Jinsheng.. Innate immune effect and its expression level in oral tissues of follicular dendritic cells secreted protein [J]. Inter J Stomatol, 2014, 41(4): 444-447.
[15] Li Jin1, Liao Guiqing2, Chen Jufeng1, Liu Haichao2, Su Yuxiong2, Feng Lianqiang3, Luo Xiaofeng4.. Isolation and identification of exosomes secreted from cell line Tca8113 in tongue cancer [J]. Inter J Stomatol, 2014, 41(1): 23-25.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .