国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (5): 585-592.doi: 10.7518/gjkq.2019068

• 综述 • 上一篇    下一篇

头颈部鳞状细胞癌第二原发癌的研究进展

郝福1,孙睿1,2()   

  1. 1. 山西医科大学口腔医学院?口腔医院 太原 030001;
    2. 山西省人民医院口腔颌面外科 太原 030012
  • 收稿日期:2018-12-26 修回日期:2019-03-29 出版日期:2019-09-01 发布日期:2019-09-10
  • 通讯作者: 孙睿 E-mail:ruidoctor@163.com
  • 作者简介:郝福,住院医师,硕士,Email: 283425020@qq.com
  • 基金资助:
    山西省自然科学基金(2011011037-2)

Research progress on second primary carcinoma of head and neck squamous cell carcinoma

Hao Fu1,Sun Rui1,2()   

  1. 1. Dept. of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Shanxi Medical University, Taiyuan 030001, China
    2. Dept. of Oral and Maxillofacial Surgery, Shanxi Provincial People’s Hospital, Taiyuan 030012, China
  • Received:2018-12-26 Revised:2019-03-29 Online:2019-09-01 Published:2019-09-10
  • Contact: Rui Sun E-mail:ruidoctor@163.com
  • Supported by:
    This study was supported by Program for Science Foundation of Shanxi Province(2011011037-2)

摘要:

头颈部鳞状细胞癌(HNSCC)是一种常见的致死性疾病,术后第二原发癌(SPC)形成是导致其远期生存率下降的主要原因之一。SPC发生不仅与吸烟、嗜酒、咀嚼槟榔等危险因素有关,而且与致癌物代谢、DNA修复、细胞周期和细胞凋亡等多个生物学过程相关蛋白表达异常和相关基因多态性导致的遗传易感性增加有关。因此,掌握SPC发生的危险因素和分子机制对于筛选SPC的高危人群和制定恰当的治疗方案具有重要的临床意义。

关键词: 头颈部鳞状细胞癌, 第二原发癌, 危险因素, 分子机制

Abstract:

Head and neck squamous cell carcinoma (HNSCC) is a common lethal disease, in which the formation of postoperative second primary carcinoma (SPC) mainly causes the decline of long-term survival rate. The occurrence of SPC is related to smoking, alcohol consumption, betel nut chewing, and other risk factors. Furthermore, SPC also involves the abnormal expression of related proteins and increase in genetic susceptibility caused by genetic polymorphisms in carcinogen metabolism, DNA repair, cell cycle, and apoptosis. Therefore, mastering the risk factors and molecular mechanisms of SPC is highly important in screening high-risk populations of SPC and in protocol development.

Key words: head and neck squamous cell carcinoma, second primary carcinoma, risk factor, molecular mechanism

中图分类号: 

  • R739.81
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