国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (3): 326-332.doi: 10.7518/gjkq.2019007

• 综述 • 上一篇    下一篇

根面龋微生态的研究进展

杜倩1,任彪2,周学东1,徐欣1()   

  1. 1.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科 成都 610041
    2.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医学院 成都 610041
  • 收稿日期:2018-10-22 修回日期:2019-03-04 出版日期:2019-05-01 发布日期:2019-06-05
  • 通讯作者: 徐欣
  • 作者简介:杜倩,博士,Email:qiandu1991@126.com
  • 基金资助:
    国家自然科学基金(81771099);国家自然科学基金(81670978);四川省科学技术厅重大前沿项目(2016JY0006)

The microbial ecology of root caries

Qian Du1,Biao Ren2,Xuedong Zhou1,Xin Xu1()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-10-22 Revised:2019-03-04 Online:2019-05-01 Published:2019-06-05
  • Contact: Xin Xu
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81771099);This study was supported by National Natural Science Foundation of China(81670978);Key Project for Frontier Research of Science and Technology Department of Sichuan Province(2016JY0006)

摘要:

龋病的发生是在外界环境多因素作用下,牙菌斑微生态中细菌与细菌、细菌与宿主之间生态失衡,牙菌斑生物膜细菌组成由生理性组合向病理性组合演变,产酸耐酸菌获得竞争优势,牙菌斑生物膜产酸增加,牙体硬组织脱矿,最终形成肉眼可见的龋损。牙根面特殊微环境及组织学结构使根面龋的发生较牙冠部窝沟点隙龋更加复杂。根面龋的发生发展不仅包括微生物产酸导致牙体硬组织脱矿,还包括内源性、细菌源性胶原酶对牙本质胶原蛋白的溶解。牙根面微生态系中微生物具有高度多样性,相较于牙冠部,牙根面有更多的革兰阴性菌、厌氧菌和真菌定植,微生物之间的相互作用更加复杂。本文就牙根面牙菌斑微生态的研究进展进行综述,以期从微生态的角度为根面龋的防治提供新的思路。

关键词: 根面龋, 微生态, 革兰阴性菌, 厌氧菌, 白色念珠菌

Abstract:

As a clinical subtype of dental caries, root caries is a polymicrobial infectious disease resulting from dysbiosis of the microbial ecology of the mouth. In this case, highly acidogenic/aciduric species are selectively enriched while less aciduric commensal residents are suppressed within the biofilm. This feed-forward imbalance in microbial equilibrium leads to a continuous decline in pH to the threshold below which tooth hard tissue demineralization occurs. Due to the histological features of tooth dentine and cementum, as well as the impact of both saliva and gingival groove liquid, the microbial etiology of root caries is relatively complex, including not only demineralization by bacterial acidification but also organic matrix degradation. The microorganisms within root caries lesions show high diversity, including large numbers of Gram-negative bacteria, anaerobic bacteria, and even fungi. This review summarizes the characteristic microorganisms of root caries from the perspective of microbial ecology to advance our understanding of root caries.

Key words: root caries, microbial ecology, Gram-negative bacteria, anaerobic bacteria, Candida albicans

中图分类号: 

  • R781.1

表 1

根面龋特异性微生物及其在根面龋中的作用"

微生物 产酸 蛋白凝固及降解 自凝聚 共凝聚 其他
细菌 放线菌属[19,25] + + - +
乳杆菌属[19,25] + + + - 胶原特异性黏附
丙酸杆菌属[15] + + - -
普雷沃菌属[19,25] - + + +
口腔链球菌[9] - - - - 促进牙菌斑中IgA蛋白酶生成
双歧杆菌属[19,25] - - - -
欧氏菌属[26,27] - - - -
真菌 白色念珠菌[31,46-50] + + - - 与口腔微生物间交互作用
都柏林念珠菌[31] - - - -
光滑念珠菌[31] - - - -
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