国际口腔医学杂志

国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (2): 239-243.doi: 10.7518/gjkq.2017.02.025

• 综述 • 上一篇    下一篇

辅助性T细胞及其细胞因子与原发性舍格伦综合征的相关性

杜世文,俞创奇,石欢   

  1. 上海交通大学医学院附属第九人民医院口腔颌面外海市口腔医学重点实验室 上海 200011
  • 收稿日期:2016-05-23 出版日期:2017-03-01 发布日期:2017-03-01
  • 通讯作者: 俞创奇,教授,博士,Email：ycq616@hotmail.com
  • 作者简介:杜世文,硕士,Email：1553321034@qq.com
  • 基金资助:
    国家自然科学基金（81472526）; 广东省自然科学基金（2014A030313126）; 广州市科技计划（201609010015）; 中山大学光华口腔医学院本科生科研设计大赛项目 （2015B003）

Primary Sjögren’s syndrome and helper T cells and their cytokines

Du Shiwen, Yu Chuangqi, Shi Huan.   

  1. Dept. of Oral and Maxillofacial Surgery, College of Stomatology, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
  • Received:2016-05-23 Online:2017-03-01 Published:2017-03-01
  • Supported by:
    This study was supported by the National Natural Science Foundation of China(81472526), the Natural Sciences Founda-tion of Guangdong(2014A030313126), the Science and Technology Program of Guangzhou(201609010015) and the Undergraduate Research Project of Guanghua School of Stomatology, Sun Yat-sen University(2015B003).

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摘要： 舍格伦综合征（SS）是一种主要累及泪腺和唾液腺等外分泌腺的系统性自身免疫性疾病,分为原发性舍格伦综合征（pSS）和继发性舍格伦综合征（sSS）。辅助性T（Th ）细胞中Th1与Th2细胞分化不平衡,Th17细胞与Treg细胞免疫失衡可能对pSS的发生及其发展产生影响。Th细胞分泌的白细胞介素（IL）-6、IL-17、IL-21和IL-23等细胞因子在pSS发病过程中和介导SS小腺体内炎症的过程中可能起着重要的作用。其中,有关Th17细胞及其分泌的细胞因子的研究,可为pSS的治疗提供更为有力和关键的证据。

关键词: 辅助性T细胞, 舍格伦综合征, 白细胞介素

Abstract: Sjögren syndrome(SS) is an autoimmune disease that always involves the lacrimal gland and salivary gland exocrine glands, divided into primary SS(pSS) and secondary SS(sSS). Unlike T helper(Th) cells(Th1 and Th2 cells) imbalance, Th17 cell and Treg cell immune imbalance may have an impact on the occurrence and development of pSS. Th cell secretes interleukin(IL)-6, IL-17, IL-21, and IL-23 and may play an important role in the development of the pSS and the inflammation-mediated in vivo SS glandulous. The study of Th17 cell and its secretion of cytokines can provide powerful and critical evidence for the treatment of pSS in the future.

Key words: help T cell, Sjö, gren syndrome, interleukin

中图分类号: 

  • R593.2
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