Int J Stomatol ›› 2023, Vol. 50 ›› Issue (6): 632-638.doi: 10.7518/gjkq.2023094

• Oral and maxillofacial development • Previous Articles     Next Articles

Research progress on the relationship between vitamin and oral clefts

Xia Weiyao1(),Jia Zhonglin2()   

  1. 1.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Disea-ses & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-03-05 Revised:2023-08-02 Online:2023-11-01 Published:2023-10-24
  • Contact: Zhonglin Jia;
  • Supported by:
    National Natural Science Foundation of China General Program(82170919)


The relationship between vitamins and oral clefts has been a great concern.In recent years, researchers have explored the effects of vitamins on the pathogenesis of oral clefts. Vitamins may regulate palate formation, influence bone and cartilage development, alter methylation levels, or play a protective role during exposure to teratogens. Maternal vitamin levels are strongly associated with the development of oral clefts, and multivitamin supplementation during pregnancy may prevent or mitigate the development of the disease. This article provides a review of the research progress on the relationship between vitamin and oral clefts and the underlying mechanism. Results provide a basis for reasonable vitamin supplementation during pregnancy to prevent and reduce the occurrence of oral clefts.

Key words: oral cleft, vitamin, pathogenesis

CLC Number: 

  • R 782.2

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