Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (3): 249-256.doi: 10.7518/gjkq.2020055

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The definition of skeletal stem cell in bone development

Shi Yu()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-02-06 Revised:2020-02-19 Online:2020-05-01 Published:2020-05-08
  • Contact: Yu Shi E-mail:intobiooo@163.com
  • Supported by:
    The Fundamental Research Funds for the Central Universities(20822041D4014);Scientific Research Foundation for Recruited Talents, West China Hospital of Stomatology, Sichuan University(QDJF2019-2)

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Abstract:

Growing evidence supports the idea that skeletal stem cells play important roles in bone development. Over the recent years, the identification of skeletal stem cells has evolved from cells simply defined by in vitro behaviors to cells identified by a combination of ex vivo serial transplantation assays and in vitro lineage-tracing experiments. These approaches have shown better identification of the characteristics of skeletal stem cells residing in multiple tissues, including the perichondrium of the fetal bone, the resting zone of the postnatal growth plate and the adult bone marrow space. Multiple groups of skeletal stem cells seem to collaborate tightly and achieve critical biological functions of mineralized tissue, including not only bone development and growth, but also maintenance and repair. Although recently more studies have been focusing on this topic and collecting numbers of important findings, we are still beginning to understand the diversity and the nature of skeletal stem cells, and how they actually behave in vivo. Accumulating works need to be done to investigate the feature and systemic regulation of skeletal stem cells.

Key words: skeletal stem cell, identification, bone development

CLC Number: 

  • Q254

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