Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (4): 414-419.doi: 10.7518/gjkq.2018.04.008

• Reviews • Previous Articles     Next Articles

Preparation and biomedical applications of alginate-chitosan microspheres

Jin Xin1, Yang Junxing1, Wang Yingnan2, Liu Zhihui1, Wang Bowei3   

  1. 1. Dept. of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China;
    2. College of Chemistry, Jilin University, Changchun 130021, China;
    3. Dept. of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China
  • Received:2017-12-21 Revised:2018-04-18 Online:2018-07-02 Published:2018-07-02
  • Supported by:
    This study was supported by Pharmaceutical Industry Promotion Plan of Jilin Province (20140311088YY), Key Scientific and Technological Projects of Changchun City (2014054), Technology Research Program of Jilin Province (20150204004YY) and “Double Ten” Plan of Changchun City (16SS12).

Abstract: Chitosan is the only natural alkaline amino polysaccharide, and alginate is a kind of natural anionic polysac-charide. These polysaccharides are good materials for microsphere preparation because of their good biocompatibility, nontoxicity and biodegradability. This paper reviews the main methods (ion crosslinking and emulsification) of microsphere preparation by using the combination of chitosan and alginate and its application as a drug carrier in biomedicine.

Key words: chitosan, alginate, drug-loaded, control release, microsphere

CLC Number: 

  • R318.08

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