Inter J Stomatol ›› 2014, Vol. 41 ›› Issue (5): 546-551.doi: 10.7518/gjkq.2014.05.011

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Study of repairing the bone defect with platelet-rich plasma/alginate sustained release composites

Li Simin1, Guo Liangwei1, Zhou Jin2, Gao Yunfei1   

  1. 1. Dept. of Periodontics, The Affiliated Stomatological Hospital, Harbin Medical University, Harbin 150001, China; 2. Dept. of Hematology, The First Hospital of Harbin Medical University, Harbin 150001, China
  • Received:2014-01-12 Revised:2014-05-26 Online:2014-09-01 Published:2014-09-01


Objective This study aimed to investigate and compare the biological potential of two types of platelet rich plasma(PRP) loaded alginate hydrogel(PRP alginate beads and PRP alginate capsules) through animal tests in vivo. Methods A critical size defect of 15mm elongation was created in the mid-upper part of bilateral radius of 45 New Zealand white rabbits and either suppied with PRP alginate beads(14 rabbits), and PRP alginate capsules(14 rabbits), PRP gel(14 rabbits), and untreated(4 rabbits). After 8, 12 weeks of implantation, the gross, radiological and histological observations were performed to investigate the bone healing of the defect. Results All of the defects treated with transplant materials exhibited new bone formation 8 and 12 weeks postoperatively, increasing with time. The radiological and histomorphological evaluation showed that the ability of new bone formation was arranged in 3 groups as follows: PRP alginate beads>PRP alginate capsules>PRP gel, the difference was significant between them(P<0.05). Successful bone regeneration was observed at the bone defect applied(treated) with PRP alginate beads, which is marked contrast to other groups. Conclusion PRP alginate beads could be a promising material capable of enhancing bone regeneration.

Key words: platelet-rich plasma, alginate, sustained release carrier, radius bone defect

CLC Number: 

  • R 782.13

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