Int J Stomatol

Inter J Stomatol ›› 2014, Vol. 41 ›› Issue (1): 36-39.doi: 10.7518/gjkq.2014.01.009

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Histological study on the intra-articular injection of glucosamine in the temporomandibular joint osteoarthritis treatment of rabbits

Yin Jian1, Liao Shuang1, Zhang Weihua2, He Jia3, Wang Hang1.   

  1. 1. State Key Laboratory of Oral Diseases, Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; 2. Dept. of Teaching and Research, The Fourth Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China; 3. State Key Laboratory of Oral Diseases, Dept. of Temporomandihular Joint, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2012-11-14 Revised:2013-07-31 Online:2014-01-01 Published:2014-01-01

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Abstract:

Objective This study aims to investigate the effect of glucosamine intra-articular injection in temporomandibular joint(TMJ) osteoarthritis(OA) treatment of rabbits. Methods Intra-articular injection of type Ⅱ collagenase was performed bilaterally in six rabbits to induce OA(3 mg each on Days 1 and 4). On Week 6, the right joint(experimental group) was injected with glucosamine(once a week for 5 weeks), and the left joint(control group) was injected with physiological saline. On Week 11, six rabbits were sacrificed, and the TMJs were dissected for histological comparison. Results All joints showed osteoarthritic-like change, but the degree in the experimental group was significantly less severe than that in the control group. Moreover, the scale of the experiment group was significantly less than that of the control group. Conclusion Intra-articular injection of glucosamine can significantly relieve TMJ OA in rabbits.

Key words: temporomandibular joint, osteoarthritis, glucosamine, therapy


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