Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (6): 699-705.doi: 10.7518/gjkq.2024101

• Orthodontics • Previous Articles    

Progress of the research on four promising biopharmaceuticals for intervening in orthodontic recurrence

Man Liu1(),Yao Meng2(),Mao Niu1   

  1. 1.School of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen 518048, China
    2.Dept. of Orthodontics, Shenzhen Children’s Hospital, Shenzhen 518000, China
  • Received:2024-04-15 Revised:2024-09-18 Online:2024-11-01 Published:2024-11-04
  • Contact: Yao Meng E-mail:liumandentist@126.com;57397527@qq.com
  • Supported by:
    Guangdong Provincial Department of Education’s Characteristic Innovation Project for Ordinary Universities(2019GKTSCX091);Free Exploration Project of Shenzhen Science and Technology Innovation Committee(JCYJ20180228164957104);Shenzhen Science and Technology Innovation Committee University Stability Support Pro-ject([2021]0877)

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Abstract:

Orthodontic relapse remains a prominent focus in orthodontic research owing to its clinical importance. Current insights suggest that the physiological similarity between orthodontic tooth movement and subsequent relapse warrants the exploration of biochemical agents targeting alveolar bone remodeling processes. Such agents, which can modulate the rate of orthodontic tooth movement, hold promise for regulating orthodontic relapse. The investigation of interventions for orthodontic relapse, primarily through local and systemic drug administration, is predominantly in the in vitro experimental stage. Notably, in animal studies, certain biopharmaceuticals have emerged as pivotal avenues of research due to their noninvasive nature, minimal side effects, and facile administration. This review synthesizes the osteogenic mechanisms and foundational research concerning four classes of biological drugs implicated in postorthodontic relapse: psoralen, phytoestrogenic isoflavone, lactoferrin, and the estrogen receptor modulator raloxifene.

Key words: orthodontic tooth movement, relapse, biomedical drugs, traditional Chinese medicine

CLC Number: 

  • R783.5

TrendMD: 

Fig 1

The research mechanism of regulating bone homeostasis and promoting bone formation by using Fructus Psorale, Epiflavones, Lactoferrin, and Raloxifene"

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