Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (2): 201-207.doi: 10.7518/gjkq.2024031

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Research progress of primary cilia in bone remodelling and reconstruction of temporomandibular joint cartilage under mechanical stress

Qing Xue(),Huichuan Qi,Min Hu()   

  1. Dept. of Orthodontics, Hospital of Stomatology, Jilin University, Changchun 130021, ChinaCorrespordence: Hu Min, Email: humin@jlu. edu. cn
  • Received:2023-06-27 Revised:2023-11-10 Online:2024-03-01 Published:2024-03-11
  • Contact: Min Hu E-mail:xueqing21@mails.jlu.edu.cn;humin@jlu.edu.cn
  • Supported by:
    National Natural Science Foundation of China Youth Science Foundation Project(82100956)

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Abstract:

Tooth movement and temporomandibular joint remodelling during orthodontic treatment are typical biomechanical processes that involve bone remodelling and maintenance of cartilage homeostasis. Primary cilia are mechanoreceptors that widely exist on the surface of mesenchymal stem cells (MSCs), osteoblasts, osteocytes, chondrocytes, and other cells. Under mechanical stress, primary cilia could promote the osteogenic differentiation of MSCs and maintain the mechani-cal sensitivity of osteoblasts. Primary cilia could also promote the deposition of the bone matrix, upregulate the functional activity of osteocytes, and indirectly regulate the activity of osteoclasts. They promote the proliferation, differentiation, and endochondral ossification of chondrocytes by transducing multiple signalling pathways and thus play an important role in bone-cartilage tissue remodelling. This article aims to review the research progress of primary cilia in alveolar bone remodelling and reconstruction of temporomandibular joint cartilage. Relevant molecular mechanisms are discussed. This work provides a reference to further explore the mechanisms of bone and cartilage tissue remodelling during orthodontic treatment.

Key words: primary cilia, mechanotransduction, orthodontic tooth movement, temporomandibular joint

CLC Number: 

  • R783.5

TrendMD: 
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