Int J Stomatol

Inter J Stomatol ›› 2019, Vol. 46 ›› Issue (2): 135-141.doi: 10.7518/gjkq.2019010

• Systematic Reviews • Previous Articles     Next Articles

Xenogeneic collagen matrix versus autogenous connective tissue graft in periodontal soft tissue augmentation: a systematic review and Meta-analysis

Fangfang Fang1,Yaqin Chang1,Yingchun Dong2,Shasha Qin3,Bin Chen1()   

  1. 1. Dept. of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China
    2.Dept. of Anesthesiology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China
    3.Dept. of Chronic Non-communicable Diseases Prevention and Control, Xi’an Center for Disease Control and Prevention, Xi’an 710054, China)
  • Received:2018-07-22 Revised:2018-12-15 Online:2019-03-01 Published:2019-03-15
  • Contact: Bin Chen E-mail:361734128@qq.com
  • Supported by:
    This study was supported by Nanjing Medical Science and Technique Development Foundation(QRX17176);Jiangsu Provincial Medical Youth Talent, the Project of Invigorating Health Care though Science, Technology and Education(QNRC2016117)

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Abstract:

Objective In this systematic review, we aimed to compare the effectiveness of xenogeneic collagen matrix (XCM) and autogenous connective tissue graft (CTG) in periodontal soft tissue augmentation. Methods We searched randomized controlled clinical studies published from 2000 to July 2018 in electronic databases, including PubMed, EMbase, Cochrane, Web of Science, CNKI, CBM, Wanfang database, and VIP. RevMan5.3 software was used to analyze and compare the width of keratinized tissue (KTW), thickness of keratinized tissue (TKT), average root coverage (ARC), and surgery time. Results A total of 10 randomized controlled trials were included. There was no difference between XCM and CTG (P>0.05) in terms of the augmentation of KTW and ARC at the follow time of 6 months, XCM was less effective than CTG at 12 months. CTG had a higher augmentation in TKT compared with XCM (P<0.05) at 12 months. XCM needed shorter operation time than CTG (P<0.05). Conclusion The limited evidence showed XCM had similar augmentation of KTW and ARC. There was insufficient evidence to prove that CTG was more effective in the augmentation of TKT than XCM and that XCM required shorter surgery time. Long-term, multicenter, and prospective randomized controlled clinical studies with large sample sizes are necessary to further validate the problem.

Key words: xenogeneic collagen matrix, connective tissue graft, soft tissue augmentation

CLC Number: 

  • R781.4

TrendMD: 

Tab 1

Characteristics of included studies"

研究 试验设计 数量（患者/位点） 年龄/岁 材料（试验组/ 对照组） 牙体类型 颌位 观察指标 研究时
长/月		 测量时间点/月
Sanz等[12] RCT（平行对照） 20/20 T：64.3
C：59.2		 XCM（MG）/ CTG 天然牙/种植体 NR KTW、手术时间 6 0、1、3、6
McGuire等[13] RCT（平行对照） 25/50 43.7±12.2 XCM（MG）/ CTG 天然牙 上下颌 KTW、ARC 12 0、1、2、3、6、12
Cardaropoli等[14] RCT（平行对照） 18/22 41.39±10.02 XCM（MG）/ CTG 天然牙 T：上颌7下颌4 C：上颌11 KTW、TKT、ARC 12 0、1、3、6、12
Lorenzo等[15] RCT（平行对照） 24/24 T：62±8.7
C：63±7.9		 XCM（MG）/ CTG 种植体 T：上颌1下颌11 C：下颌12 KTW、手术时间 6 0、1、3、6
Aroca等[16] RCT（口内分组对照） 22/156 >18 XCM（MG）/ CTG 天然牙 上下颌 KTW、TKT、ARC、手术时间 12 0、1、3、6、12
Cie?lik-Wege-mund等[17] RCT（平行对照） 28/106 20~50 XCM（MD）/ CTG 天然牙 上下颌 KTW、ARC 6 0、3、6
Cairo等[18] RCT（平行对照） 60/60 T：50.3±12.4
C：48.3±11.8		 XCM（MG）/ CTG 种植体 上下颌 KTW、TKT、手术时间 6 0、1、3、6
Thoma等[11] RCT 20/20 T：64.3
C：59.2		 XCM（MG）/ CTG 种植体 T：上颌10
C：上颌 9下颌1		 TKT、手术时间 3 0、1、3
Puzio等[19] RCT 25/30 T：43.8±13.2
C：42.7±19.1		 XCM（MG）/ CTG 种植体 T：上颌12下颌3
C：上颌14下颌1		 TKT 12 0、3、12
Tatarakis等[20] RCT 8/8 T：38.75±11.70
C：37.75±18.17		 XCM（MG）/ CTG 天然牙 上颌 KTW 6 0、2、6

Tab 2

Risk of bias of included studies"

纳入研究 随机序列生成 分配隐藏 实施盲法 结果测量盲法 失访偏倚 报告偏倚 其他偏倚
Sanz等[12] 恰当 恰当 恰当 不清楚 不清楚 不清楚 恰当
McGuire等[13] 恰当 不清楚 恰当 恰当 恰当 恰当 恰当
Cardaropoli等[14] 恰当 不清楚 恰当 恰当 恰当 恰当 恰当
Lorenzo等[15] 恰当 恰当 恰当 恰当 恰当 不清楚 恰当
Aroca等[16] 恰当 恰当 恰当 恰当 恰当 恰当 恰当
Cie?lik-Wegemund等[17] 恰当 恰当 恰当 不恰当 恰当 恰当 恰当
Cairo等[18] 恰当 恰当 恰当 恰当 恰当 恰当 恰当
Thoma等[11] 恰当 恰当 恰当 恰当 不恰当 不清楚 恰当
Puzio等[19] 恰当 恰当 不清楚 恰当 恰当 恰当 恰当
Tatarakis等[20] 恰当 恰当 恰当 不清楚 恰当 恰当 恰当

Fig 1

Meta-analysis of the increase in KTW"

Fig 2

Meta-analysis of the increase in TKT"

Fig 3

Meta-analysis of ARC"

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