Int J Stomatol ›› 2026, Vol. 53 ›› Issue (4): 503-512.doi: 10.7518/gjkq.2026621

• Implantology • Previous Articles     Next Articles

Research progress on autogenous tooth bone graft for the repair of maxillofacial bone defects

Yuting Ye(),Yang Ma,Jiafei Sun,Yi Zhu,Ping Sun()   

  1. Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000
  • Received:2025-02-13 Revised:2026-03-30 Online:2026-07-01 Published:2026-06-25
  • Contact: Ping Sun E-mail:3190104243@zju.edu.cn;nosleep@zju.edu.cn
  • Supported by:
    Basic Public Welfare Research Program of Zhejiang Province(LGF22H140007);Exploration and R&D Project of Stomatology Hospital, Zhejiang University School of Medicine(RD2022JCXK01)

Abstract:

Maxillofacial bone defect repair is a common clinical problem in the oral field and mainly uses bone graft materials for repair. As a new type of bone grafting material with good biocompatibility, osteoconductivity, osteoinductivity, and biodegradability, autogenous tooth bone graft has shown advantages in clinical application. This study reviews the characteristics, preparation, influencing factors, and clinical application of autogenous tooth bone graft to provide a refe-rence for its clinical application.

Key words: autogenous tooth bone graft, maxillofacial bone defect, bone graft

CLC Number: 

  • R782.13

TrendMD: 

Fig 1

ATBG for the repair of maxillofacial bone defects"

Fig 2

The preparation of ATBG"

Fig 3

The clinical application of ATBG"

[1] Zhao R, Yang RJ, Cooper PR, et al. Bone grafts and substitutes in dentistry: a review of current trends and developments[J]. Molecules, 2021, 26(10): 3007.
[2] Louis PJ, Sittitavornwong S. Managing bone grafts for the mandible[J]. Oral Maxillofac Surg Clin N Am, 2019, 31(2): 317-330.
[3] Yeomans JD, Urist MR. Bone induction by decalcified dentine implanted into oral, osseous and muscle tissues[J]. Arch Oral Biol, 1967, 12(8): 999-1008.
[4] Kim HS, Yun PY, Kim YK. Intentional partial odontectomy: a long-term follow-up study[J]. Maxillofac Plast Reconstr Surg, 2017, 39(1): 29.
[5] Kim YK, Kim SG, Oh JS, et al. Analysis of the inorganic component of autogenous tooth bone graft material[J]. J Nanosci Nanotech, 2011, 11(8): 7442-7445.
[6] Qian JJ, Bhatnagar RS. Enhanced cell attachment to anorganic bone mineral in the presence of a synthe-tic peptide related to collagen[J]. J Biomed Mater Res, 1996, 31(4): 545-554.
[7] Ripamonti U, Ramoshebi LN, Matsaba T, et al. Bone induction by BMPs/OPs and related family members in primates[J]. J Bone Joint Surg Am, 2001, 83A(): 116-127.
[8] 李博, 吴大雷, 闫建伟, 等. 新型骨移植材料自体牙骨粉的研究与进展[J]. 中华口腔医学杂志, 2015, 50(12): 765-767.
Li B, Wu DL, Yan JW, et al. Research and development of the autogenous tooth bone graft materia[J]. Chin J Stomatol, 2015, 50(12): 765-767.
[9] Nakashima M. Bone morphogenetic proteins in dentin regeneration for potential use in endodontic the-rapy[J]. Cytokine Growth Factor Rev, 2005, 16(3): 369-376.
[10] Kim YK, Kim SG, Bae JH, et al. Guided bone regeneration using autogenous tooth bone graft in implant therapy[J]. Implant Dent, 2014, 23(2): 138- 143.
[11] Kim YK, Kim SG, Yun PY, et al. Autogenous teeth used for bone grafting: a comparison with traditio-nal grafting materials[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2014, 117(1): e39-e45.
[12] Mahardawi B, Rochanavibhata S, Jiaranuchart S, et al. Autogenous tooth bone graft material prepared chairside and its clinical applications: a systematic review[J]. Int J Oral Maxillofac Surg, 2023, 52(1): 132-141.
[13] Korsch M. Tooth shell technique: a proof of concept with the use of autogenous dentin block grafts[J]. Aust Dent J, 2021, 66(2): 159-168.
[14] Kim YK, Yun PY, Um IW, et al. Alveolar ridge pre-servation of an extraction socket using autogenous tooth bone graft material for implant site development: prospective case series[J]. J Adv Prosthodont, 2014, 6(6): 521.
[15] Kim MG, Lee JH, Kim GC, et al. The effect of autogenous tooth bone graft material without organic matter and type Ⅰ collagen treatment on bone rege-neration[J]. Maxillofac Plast Reconstr Surg, 2021, 43(1): 17.
[16] Koga T, Minamizato T, Kawai Y, et al. Bone rege-neration using dentin matrix depends on the degree of demineralization and particle size[J]. PLoS One, 2016, 11(1): e0147235.
[17] Akazawa T, Murata M, Hino J, et al. Surface structure and biocompatibility of demineralized dentin matrix granules soaked in a simulated body fluid[J]. Appl Surf Sci, 2012, 262: 51-55.
[18] 梁韩莹, 马云豪, 李涵, 等. 部分脱矿自体牙本质颗粒在种植位点保存术中的成骨效能[J]. 中国组织工程研究, 2023, 27(16): 2488-2492.
Liang HY, Ma YH, Li H, et al. Osteogenic effects of partially demineralized autogenous dentin particles in implant site preservation[J]. Chin J Tiss Eng Res, 2023, 27(16): 2488-2492.
[19] Inchingolo AM, Patano A, di Pede C, et al. Autologous tooth graft: innovative biomaterial for bone regeneration. tooth transformer® and the role of microbiota in regenerative dentistry. A systematic review[J]. J Funct Biomater, 2023, 14(3): 132.
[20] Korsch M, Peichl M. Retrospective study: lateral ridge augmentation using autogenous dentin: tooth-shell technique vs. bone-shell technique[J]. Int J Environ Res Public Heal, 2021, 18(6): 3174.
[21] Kim YK, Pang KM, Yun PY, et al. Long-term follow-up of autogenous tooth bone graft blocks with dental implants[J]. Clin Case Rep, 2017, 5(2): 108-118.
[22] Calvo-Guirado JL, Ballester Montilla A, de Aza PN, et al. Particulated, extracted human teeth characte-rization by SEM-EDX evaluation as a biomaterial for socket preservation: an in vitro study[J]. Mate- rials, 2019, 12(3): 380.
[23] Becker K, Drescher D, Hönscheid R, et al. Biomechanical, Micro-computed tomographic and immunohistochemical analysis of early osseous integration at titanium implants placed following lateral ridge augmentation using extracted tooth roots[J]. Clin Oral Implant Res, 2017, 28(3): 334-340.
[24] 戴薇, 席月, 陈朝真, 等. 自体牙移植物在骨增量中的研究进展[J]. 口腔医学, 2022, 42(3): 250-255.
Dai W, Xi Y, Chen CZ, et al. Research progress of autogenous tooth materials in alveolar ridge augmentation[J]. Stomatology, 2022, 42(3): 250-255.
[25] Schwarz F, Golubovic V, Becker K, et al. Extracted tooth roots used for lateral alveolar ridge augmentation: a proof-of-concept study[J]. J Clin Periodontol, 2016, 43(4): 345-353.
[26] Melek LN, El Said MM. Evaluation of “Autogenous Bioengineered Injectable PRF-Tooth graft” combination (ABIT) in reconstruction of maxillary alveolar ridge defects: CBCT volumetric analysis[J]. Saudi J Dent Res, 2017, 8(1/2): 86-96.
[27] Kabir MA, Murata M, Shakya M, et al. Bio-absorption of human dentin-derived biomaterial in sheep critical-size iliac defects[J]. Materials, 2021, 14(1): 223.
[28] Amer O, Shemais N, Fawzy El-Sayed K, et al. Does injectable platelet-rich fibrin combined with autogenous demineralized dentine enhance alveolar ridge preservation? A randomized controlled trial[J]. Clin Oral Implant Res, 2025, 36(2): 166-177.
[29] Andrade C, Camino J, Nally M, et al. Combining autologous particulate dentin, L-PRF, and fibrinogen to create a matrix for predictable ridge preservation: a pilot clinical study[J]. Clin Oral Invest, 2020, 24(3): 1151-1160.
[30] Zhang SX, Li XH, Qi YX, et al. Comparison of autogenous tooth materials and other bone grafts[J]. Tissue Eng Regen Med, 2021, 18(3): 327-341.
[31] Hussain N, Khan MA, Mahmood AK, et al. An eva-luation of osseous regeneration capability of novel autogenous tooth graft along with orthobiologics for long bone segmental defects[J]. Heliyon, 2025, 11(2): e41932.
[32] Schwarz F, Golubovic V, Mihatovic I, et al. Perio-dontally diseased tooth roots used for lateral alveolar ridge augmentation. A proof-of-concept study[J]. J Clin Periodontol, 2016, 43(9): 797-803.
[33] Schwarz F, Golubovic V, Becker K, et al. Extracted tooth roots used for lateral alveolar ridge augmentation: a proof-of-concept study[J]. J Clin Periodontol, 2016, 43(4): 345-353.
[34] Beca-Campoy T, Sánchez-Labrador L, Blanco-Antona LA, et al. Alveolar ridge preservation with au-togenous tooth graft: a histomorphometric analysis of 36 consecutive procedures[J]. Ann Anat, 2025, 258: 152375.
[35] Mahardawi B, Damrongsirirat N, Dhanesuan K, et al. Radiographic changes after alveolar ridge preservation using autogenous raw tooth particles versus xenograft: a prospective controlled clinical trial[J]. Clin Oral Implant Res, 2024, 35(12): 1597-1606.
[36] Minetti E, Corbella S, Taschieri S, et al. Tooth as graft material: histologic study[J]. Clin Implant Dent Rel Res, 2022, 24(4): 488-496.
[37] Li JY, Jin FF, Wang RF, et al. Guided bone regeneration in a periodontally compromised individual with autogenous tooth bone graft: a radiomics analysis[J]. J Funct Biomater, 2023, 14(4): 220.
[38] Jeong KI, Kim SG, Kim YK, et al. Clinical study of graft materials using autogenous teeth in maxillary sinus augmentation[J]. Implant Dent, 2011, 20(6): 471-475.
[39] Jun SH, Ahn JS, Lee JI, et al. A prospective study on the effectiveness of newly developed autogenous tooth bone graft material for sinus bone graft procedure[J]. J Adv Prosthodont, 2014, 6(6): 528.
[40] 崔婷婷, 寇霓, 仲维剑, 等. 自体牙本质颗粒联合富血小板纤维蛋白在上颌窦提升同期种植中的应用[J]. 口腔医学研究, 2018, 34(5): 532-534.
Cui TT, Kou N, Zhong WJ, et al. Application of autologous dentine granules and platelet rich fibrin in maxillary sinus lateral lift surgery[J]. J Oral Sci Res, 2018, 34(5): 532-534.
[41] Choi H, Sohn DS. Retrospective study of maxillary sinus augmentation using demineralized tooth block bone for dental implant[J]. Bioengineering, 2024, 11(6): 633.
[42] Schwarz F, Hazar D, Becker K, et al. Short-term outcomes of staged lateral alveolar ridge augmentation using autogenous tooth roots. A prospective controlled clinical study[J]. J Clin Periodontol, 2019, 46(9): 969-976.
[43] Parvini P, Sahin D, Becker K, et al. Short-term outcomes of lateral extraction socket augmentation using autogenous tooth roots: a prospective observational study[J]. Clin Oral Implant Res, 2020, 31(9): 881-888.
[44] Schwarz F, Ramanauskaite A, Wetzel W, et al. Clinical outcomes following a combined vertical and ho-rizontal alveolar ridge augmentation and two-stage implant placement using either autogenous tooth roots or autogenous bone blocks[J]. Clin Implant Dent Relat Res, 2024, 26(2): 369-375.
[45] Bjelica R, Smojver I, Vuletić M, et al. Lateral alveolar ridge augmentation with autogenous tooth roots and staged implant placement: 5-year follow-up case series[J]. J Clin Med, 2024, 13(17): 5118.
[46] 曾婷雯, 赵莹琼, 张敬阳. 牙本质片在种植水平骨增量中的短期临床应用[J]. 口腔医学研究, 2023, 39(2): 151-155.
Zeng TW, Zhao YQ, Zhang JY. Short-term clinical application of dentin slices in horizontal bone augmentation[J]. J Oral Sci Res, 2023, 39(2): 151-155.
[47] Li P, Zhu HC, Huang DH. Autogenous DDM versus Bio-Oss granules in GBR for immediate implantation in periodontal postextraction sites: a prospective clinical study[J]. Clin Implant Dent Rel Res, 2018, 20(6): 923-928.
[48] Cinar IC, Zboun M, Saglanmak A, et al. Immediate implantation with autologous mineralized dentin graft versus deproteinized bovine bone as space-fil-ling substitute in maxillary anterior zone: retrospective radiological and clinical study[J]. J Clin Med, 2024, 13(18): 5521.
[49] Kim YK, Lee JH, Um IW, et al. Guided bone rege-neration using demineralized dentin matrix: long-term follow-up[J]. J Oral Maxillofac Surg, 2016, 74(3): 515.e1-515.e9.
[50] Lee JY, Lee J, Kim YK. Comparative analysis of guided bone regeneration using autogenous tooth bone graft material with and without resorbable membrane[J]. J Dent Sci, 2013, 8(3): 281-286.
[51] Minetti E, Gianfreda F, Palermo A, et al. Autogenous dentin particulate graft for alveolar ridge augmentation with and without use of collagen membrane: preliminary histological analysis on humans[J]. Materials, 2022, 15(12): 4319.
[52] Ku JK, Kwak HW, Um IW. Incorporating moldable demineralized dentin matrix into treatment for a jaw cyst[J]. J Funct Biomater, 2023, 14(5): 258.
[53] Wushou A, Luo Y, Cheng QT, et al. Using autogenous tooth sticky bone graft repair mandibular third molar dentigerous cyst osseous defects[J]. BMC Oral Heal, 2024, 24(1): 39.
[54] Sapoznikov L, Haim D, Zavan B, et al. A novel porcine dentin-derived bone graft material provides effective site stability for implant placement after tooth extraction: a randomized controlled clinical trial[J]. Clin Oral Invest, 2023, 27(6): 2899-2911.
[55] 王媛, 王稚英, 王明. 同种异体牙源性骨移植材料修复兔颅骨缺损的实验研究[J]. 中国医科大学学报, 2016, 45(12): 1082-1085.
Wang Y, Wang ZY, Wang M. Experimental study of the repair of rabbit skull defects with allogeneic tooth derived bone graft material[J]. J China Med Univ, 2016, 45(12): 1082-1085.
[56] Um IW, Hwang SH, Kim YK, et al. Demineralized dentin matrix combined with recombinant human bone morphogenetic protein-2 in rabbit calvarial defects[J]. J Korean Assoc Oral Maxillofac Surg, 2016, 42(2): 90.
[57] Upadhyay P, Blaggana V, Tripathi P, et al. Treatment of furcation involvement using autogenous tooth graft with 1-year follow-up: a case series[J]. Clin Adv Periodontics, 2019, 9(1): 4-8.
[58] 毛新霞, 林晓炜, 魏轩, 等. 自体牙本质颗粒与Bio-Oss骨粉植入引导骨再生治疗牙周骨缺损效果比较[J]. 上海口腔医学, 2022, 31(5): 530-534.
Mao XX, Lin XW, Wei X, et al. Comparative analysis of the effect of autologous dentin particles and implantation of Bio-Oss on guided bone regeneration in the treatment of periodontal bone defects[J]. Shanghai J Stomatol, 2022, 31(5): 530-534.
[59] Gual-Vaqués P, Polis-Yanes C, Estrugo-Devesa A, et al. Autogenous teeth used for bone grafting: a systematic review[J]. Med Oral Patol Oral Cir Bucal, 2018, 23(1):e112-e119.
[60] Mahardawi B, Thet PH, Phrueksotsai C, et al. Use of autogenous tooth bone graft in osseous defects after the surgical removal of mandibular third molars: a systematic review and Meta-analysis of rando-mized controlled trials[J]. Int J Oral Maxillofac Surg, 2025, 54(8): 777-784.
[61] Wushou A, Zheng Y, Han Y, et al. The use of autogenous tooth bone graft powder in the treatment of osseous defects after impacted mandibular third molar extraction: a prospective split-mouth clinical pilot study[J]. BMC Oral Heal, 2022, 22(1): 433.
[62] Jain A, Gupta DS, Donepudi N, et al. Is ADDM graft practical? A comparative study to evaluate ADDM graft in third molar surgery[J]. Oral Maxillofac Surg, 2025, 29(1): 26.
[63] 李博, 闫建伟. 自体牙来源骨移植材料在牙槽骨植骨术中的应用价值[J]. 大连医科大学学报, 2023, 45(5): 431-438.
Li B, Yan JW. Clinical application of autogenous tooth bone graft material in alveolar bone grafting[J]. J Dalian Med Univ, 2023, 45(5): 431-438.
[64] Murata M, Nakanishi Y, Kusano K, et al. Immediate tooth autotransplantation with root canal filling and partially demineralized dentin/cementum matrix into congenital missing tooth region[J]. J Funct Biomater, 2022, 13(2): 82.
[65] Jeong KI, Lee J, Um IW, et al. Alveolar cleft restoration using autogenous tooth bone graft material for implant placement: a case report[J]. J Oral Implantol, 2015, 41(4): 487-490.
[66] Datarkar A, Bhawalkar A. Utility of tooth as an autogenous graft material in the defects of alveolar cleft—a novel case report[J]. J Oral Biol Craniofacial Res, 2020, 10(4): 470-473.
[67] Mahardawi B, Jiaranuchart S, Tompkins KA, et al. Efficacy of the autogenous dentin graft for implant placement: a systematic review and Meta-analysis of randomized controlled trials[J]. Int J Oral Maxillofac Surg, 2023, 52(5): 604-612.
[68] Abulhassan A, El Halawani G, Sweedan O. Compa-rison of autogenous fresh demineralized dentin and beta-tricalcium phosphate in immediate implant placement of mandibular molars (randomized clinical controlled trial)[J]. Alex Dent J, 2024: 10.21608/adjalexu.2023.216442.1389.
[69] 龚佳明, 张启航, 苟萍, 等. 自体牙本质用于牙槽嵴增量的Meta分析[J]. 华西口腔医学杂志, 2022, 40(5): 566-575.
Gong JM, Zhang QH, Gou P, et al. Meta-analysis of application of autogenous dentin for alveolar ridge augmentation[J]. West China J Stomatol, 2022, 40(5): 566-575.
[70] Minamizato T, Koga T, Takashi I, et al. Clinical application of autogenous partially demineralized dentin matrix prepared immediately after extraction for alveolar bone regeneration in implant dentistry: a pilot study[J]. Int J Oral Maxillofac Surg, 2018, 47(1): 125-132.
[71] Kim YK, Kim SG, Lim SC. Familial tooth bone graft for ridge and sinus augmentation: a report of two cases[J]. J Korean Assoc Oral Maxillofac Surg, 2014, 40(1): 37.
[1] Zhang Xidan,Sun Jiyu,Fu Xinliang,Gan Xueqi.. Research progress on the development of mesoporous calcium silicate nanoparticles in endodontics and repairing maxillofacial bone defects [J]. Int J Stomatol, 2022, 49(4): 476-482.
[2] Zhao Binbin,Zhong Weijian,Ma Guowu. Research progress on dentin as bone transplantation material [J]. Int J Stomatol, 2021, 48(1): 82-89.
[3] Chen Yiyin,Liu Junqi,Li Chenghao. Effects of cleft characteristics and orthodontic treatment on alveolar bone grafting in patients with cleft lip and palate [J]. Int J Stomatol, 2020, 47(3): 345-350.
[4] Yan Mingdong, Xia Haibin, Wang Min. Clinical research progress on simultaneous crestal sinus floor lift and dental implant placement without bone graft [J]. Inter J Stomatol, 2018, 45(2): 238-244.
[5] Wang Yang, Shen Yuqin, Yu Wenwen, Sun Xinhua. Reasearch progress on modified mesoporous bioactive glasses for repairing maxillofacial bone defects [J]. Inter J Stomatol, 2018, 45(1): 32-35.
[6] Lu Yong, Shi Bing, Wang Zhiyong, Li Hao. Clinical study on secondary alveolar bone grafting by lip side combined with palate side approach [J]. Inter J Stomatol, 2017, 44(1): 19-23.
[7] Xu Xue1, Yang Chao1, Liu Kun1, Huang Ning2, Zheng Qian1, Shi Bing1. Advances in cleft alveolar repair [J]. Inter J Stomatol, 2016, 43(4): 428-437.
[8] Liu Jia, Xie Zhigang, Bao Jibo. Evaluation methods of the osteogenesis effects on bone graft material [J]. Inter J Stomatol, 2015, 42(2): 173-176.
[9] Zhu Shiwen, Chen Zhenqi. Research progress on gingival recession adjacent to the cleft in cleft lip and palate [J]. Inter J Stomatol, 2013, 40(3): 385-388.
[10] Shao Qinghua, Chen Zhenqi.. Relationship between alveolar cleft bone grafting and facial skeletal growth [J]. Inter J Stomatol, 2013, 40(1): 132-134.
[11] Liu Kun, Chen Qi, Zheng Qian.. Application progress of three -dimensional CT used in alveolar cleft bone grafting [J]. Inter J Stomatol, 2012, 39(1): 55-58.
[12] ZHOU Lei.. Research progress on maxillary sinus floor elevation surgery [J]. Inter J Stomatol, 2011, 38(1): 1-6.
[13] ZHANG Dong-jie, QIAN Yufen.. Research advances of tissue engineering bone on repairing of alveolar cleft [J]. Inter J Stomatol, 2011, 38(1): 36-39.
[14] YUAN Meng-jiang, WANG Ya, YAO Yao, TANG Xiu-fa, HUA Cheng-ge. Influence of periosteum on revascularization of free bone graft [J]. Inter J Stomatol, 2010, 37(3): 257-257~261.
[15] CHEN Mu , HUANG Hong-zhang . Application of tissue engineering strategies in reparating cleft palate [J]. Inter J Stomatol, 2009, 36(6): 732-734.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!