Int J Stomatol

Int J Stomatol ›› 2026, Vol. 53 ›› Issue (1): 10-18.doi: 10.7518/gjkq.2026203

• Orthodontics • Previous Articles     Next Articles

Research progress of mechanosensitive receptors in orthodontic tooth movement

Xuanchen Su1,2(),Yijia Dong1,Yuwen Shi1,Yali Liu1,2,3()   

  1. 1.School of Stomatology, Kunming Medical University, Kunming 650106, China
    2.Yunnan Key Laboratory of Stomatology, Kunming 650106, China
    3.Dept. of Orthodontics, Stomatological Hospital Affiliated to Kunming Medical University, Kunming 650106, China
  • Received:2024-07-17 Revised:2025-04-08 Online:2026-01-01 Published:2025-12-31
  • Contact: Yali Liu E-mail:15340852985@163.com;liuyalizu@163.com
  • Supported by:
    National Natural Science Foundation of China(31860326);Joint Fund of Yunnan Provincial Science and Technology Office and Kunming Medical University(202301AY070001-010);National College Student Innovation and Entrepreneurship Training Program(202310678040)

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Abstract:

In the process of orthodontic tooth movement, periodontal tissue related cells perceive and respond to mechanical stimulation, and the periodontal tissue adaptive reconstruction occurs, and finally the tooth movement is realized. Several mechanosensitive receptors, such as Piezo1, transient receptor potential vanilloid, primary cilia and integrin, have been found to play a role in orthodontic tooth movement, but the specific mechanisms remain to be further elucidated. In this paper, the mechanism of mechanosensitive receptors in orthodontic tooth movement in recent years and their possible interaction were summarized, in order to provide reference for the study of the mechanobiology mechanism of orthodontic tooth movement.

Key words: orthodontic tooth movement, mechanosensitive receptor, mechanobiology

CLC Number: 

  • R783.5

TrendMD: 

Fig 1

The mechanism of Piezo1 in OTM"

Fig 2

The mechanism of primary cilium in OTM"

Tab 1

Study on the mechanism of mechanical stress on orthodontic tooth movement through mechanosensitive receptors"

加力方式加力时间加力大小/幅度机械敏感性受体相关实验对象作用机制文献
静态压力0.5、3、6、12 h2 g/cm2Pizeo1hPDLCPizeo↑[7]
静态压力3、6、12、24 h2 g/cm2Piezo1牙骨质母细胞Piezo↓[18]
静态压力12 h1.5 g/cm2TRPV4PDLSCTRPV4↑[23]
循环拉伸4、8、12 h15%Pizeo1、TRPV4PDLCPizeo1↑、TRPV4↑[6]
循环拉伸24 h0、5%、12%、15%、20%Pizeo1MC3T3-E1Piezo1↑[57]
循环拉伸4、8、12 h4%、8%、12%纤毛蛋白Arl13bMC3T3-E1Arl13b↑[45]
机械拉伸1 h2.5%RhoA（整合素相关）PDLFRhoA↓[52]
OTM张力侧1、3、5、7、14 d40 gPiezo1SD大鼠Piezo1↑[13]
OTM压力侧1、3、5、7、14 d50 gPizeo1SD大鼠Pizeo1↑[8]
OTM压力侧1、3、7、14、21、28 d50 g整合素α5、β1SD大鼠整合素α5、β1↑[54]
OTM0、1、3、5、7、14 d40 gTRPV1SD大鼠TRPV1↑[24]
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