Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (3): 255-260.doi: 10.7518/gjkq.2018.03.002

• Stem Cell • Previous Articles     Next Articles

Effects of culture conditions in vitro on the biological characteristics of periodontal ligament stem cells

Jia Linglu1,2, Wen Yong1,2, Xu Xin1,2   

  1. 1. School of Stomatology, Shandong University, Jinan 250012, China;
    2. Shandong Province Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China
  • Received:2017-09-28 Revised:2018-01-15 Online:2018-05-01 Published:2018-05-01
  • Supported by:
    This study was supported by Shandong Provincial Key Research and Development Program (2016GSF201115, 2017GSF18117), China Postdoctoral Science Foundation (2017M610432) and Shandong Pharmaceutical and Health Science Technology Development Programme (2017WS111).

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Abstract: Periodontal ligament stem cell, which is a kind of adult stem cell, owns the abilities of self-renewing and multi-differentiation and has become the hot spot in the oral tissue engineering. When cultured in vitro, different culture conditions such as primary cell separation methods, culture medium composition, oxygen concentration, culture time, cell storage conditions and other physical or chemical stimulation can change the proliferation, immigration or differentiation characteristics of periodontal ligament stem cell. This paper is committed to review on the research progress regarding the effects of the culture conditions in vitro on the biological characteristics of periodontal ligament stem cell in recent years and provide theoretical reference for tissue engineering.

Key words: periodontal ligament stem cell, cell culture technique, biological characteristics

CLC Number: 

  • Q813.1+1

TrendMD: 
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