Inter J Stomatol ›› 2017, Vol. 44 ›› Issue (2): 239-243.doi: 10.7518/gjkq.2017.02.025

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Primary Sjögren’s syndrome and helper T cells and their cytokines

Du Shiwen, Yu Chuangqi, Shi Huan.   

  1. Dept. of Oral and Maxillofacial Surgery, College of Stomatology, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
  • Received:2016-05-23 Online:2017-03-01 Published:2017-03-01
  • Supported by:
    This study was supported by the National Natural Science Foundation of China(81472526), the Natural Sciences Founda-tion of Guangdong(2014A030313126), the Science and Technology Program of Guangzhou(201609010015) and the Undergraduate Research Project of Guanghua School of Stomatology, Sun Yat-sen University(2015B003).

Abstract: Sjögren syndrome(SS) is an autoimmune disease that always involves the lacrimal gland and salivary gland exocrine glands, divided into primary SS(pSS) and secondary SS(sSS). Unlike T helper(Th) cells(Th1 and Th2 cells) imbalance, Th17 cell and Treg cell immune imbalance may have an impact on the occurrence and development of pSS. Th cell secretes interleukin(IL)-6, IL-17, IL-21, and IL-23 and may play an important role in the development of the pSS and the inflammation-mediated in vivo SS glandulous. The study of Th17 cell and its secretion of cytokines can provide powerful and critical evidence for the treatment of pSS in the future.

Key words: help T cell, Sjö, gren syndrome, interleukin

CLC Number: 

  • R593.2

TrendMD: 
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