国际口腔医学杂志

国际口腔医学杂志 ›› 2026, Vol. 53 ›› Issue (1): 91-97.doi: 10.7518/gjkq.2026107

• 综述 • 上一篇    下一篇

铜死亡在牙周炎中的研究进展

石琦企(),秦旭,朱光勋()   

  1. 华中科技大学同济医学院附属同济医院口腔医学中心 华中科技大学同济医学院口腔医学院口腔颌面发育与再生湖北省重点实验室 武汉 430030
  • 收稿日期:2024-10-12 修回日期:2025-07-18 出版日期:2026-01-01 发布日期:2025-12-31
  • 通讯作者: 朱光勋
  • 作者简介:石琦企，硕士，Email：2657785772@qq.com
  • 基金资助:
    国家自然科学基金(81800981);湖北省自然科学基金(2023AFB653);湖北省自然科学基金(2023AFB765)

Research progress on cuproptosis in periodontitis

Qiqi Shi(),Xu Qin,Guangxun Zhu()   

  1. Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology & School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology & Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430030, China
  • Received:2024-10-12 Revised:2025-07-18 Online:2026-01-01 Published:2025-12-31
  • Contact: Guangxun Zhu
  • Supported by:
    National Natural Science Foundation of China(81800981);Natural Science Foundation of Hubei Pro-vince of China(2023AFB653)

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摘要：

牙周炎是一种由牙周致病菌引发的免疫炎症，失调的免疫反应和慢性炎症是导致牙周组织破坏的重要因素。铜死亡是一种新型的程序性细胞死亡形式，其由细胞内过量的铜离子所诱发，并靶向三羧酸循环过程。其以线粒体硫辛酰化蛋白质异常寡聚化和铁硫（Fe-S）簇蛋白质丢失为特征。铜死亡在心血管疾病、神经退行性疾病、癌症等多种疾病的发生发展中均发挥了不容忽视的作用。近期研究表明，铜死亡相关基因通过调控免疫细胞及细胞因子参与牙周炎发病，其异常表达反映疾病状态并辅助临床诊断，为牙周炎治疗提供新靶点。基于此，本文就铜死亡的分子机制及其在牙周炎发生发展中的作用等方面的研究进展作一综述。

关键词: 铜死亡, 牙周炎, 铜死亡相关基因

Abstract:

Periodontitis is an immune-inflammatory response triggered by periodontal pathogens. In this condition, disrupted immune responses and chronic inflammation play crucial roles in the degradation of periodontal tissues. Cuproptosis, a recently identified form of programmed cell death, is triggered by excessive intracellular copper ions and specifically targets the tricarboxylic acid cycle. It is characterized by the abnormal oligomerization of mitochondrial lipoacylated proteins and the loss of iron-sulfur cluster proteins. Cuproptosis has garnered significant attention for its nonnegligible role in the development and progression of various diseases, including cardiovascular diseases, neurodegenerative disorders, and cancers. Cuproptosis-related genes participate in the pathogenesis of periodontitis by modulating immune cells and cytokines. The abnormal expression of these genes reflects the disease status and aids in clinical diagnosis, providing novel therapeutic targets for periodontitis treatment. Considering these insights, this work presents a comprehensive review of the molecular mechanisms underlying cuproptosis and its role in the initiation and progression of periodontitis.

Key words: cuproptosis, periodontitis, cuproptosis-related genes

中图分类号: 

  • R781.4
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