国际口腔医学杂志

国际口腔医学杂志 ›› 2026, Vol. 53 ›› Issue (6): 945-954.doi: 10.7518/gjkq.2026227

• 综述 • 上一篇    

正畸源性牙根吸收治疗的干预策略与研究进展

杨淑娴(),段沛沛()   

  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 口腔疾病国家临床医学研究中心 四川大学华西口腔医院正畸科 成都 610041
  • 收稿日期:2025-07-26 修回日期:2025-09-02 出版日期:2026-11-01 发布日期:2026-10-29
  • 通讯作者: 段沛沛
  • 作者简介:杨淑娴，硕士，Email：yangsx0319@163.com
  • 基金资助:
    国家自然科学基金面上项目(82471020);四川省自然科学基金项目(2024NSFSC1593);教育部高等教育司产学合作协同育人项目（2020年第二批）

Research progress and intervention strategies in the prevention and treatment of orthodontically induced root resorption

Shuxian Yang(),Peipei Duan()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2025-07-26 Revised:2025-09-02 Online:2026-11-01 Published:2026-10-29
  • Contact: Peipei Duan
  • Supported by:
    National Natural Science Foundation of China(82471020);Sichuan Science and Technology Program(2024NSFSC1593);University-Industry Collaborative Education Program, Department of Higher Education, the Ministry of Education(the second batch in 2020)

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摘要：

正畸源性牙根吸收是正畸治疗中常见的并发症，其发生机制复杂，涉及患者个体差异以及正畸治疗等多种因素。牙根吸收可能影响牙齿的长期健康与治疗预后，因此众多学者围绕其防治策略开展了大量研究，这些研究不仅致力于通过多种手段减轻牙根吸收，更趋向于发展智能化的综合防治体系。本文针对当前主要防治策略，包括药物治疗、低强度脉冲超声、光生物调节疗法，以及基于人工智能的预测技术等的研究进展进行综述，旨在为进一步优化干预策略及开发更安全有效的治疗手段提供理论依据与参考思路。

关键词: 正畸源性牙根吸收, 药物治疗, 低强度脉冲超声, 光生物调节疗法

Abstract:

Orthodontically induced root resorption (OIRR) is a common complication during orthodontic treatment, with a complex pathogenesis involving individual patient differences and multiple treatment-related factors. Root resorption may affect the long-term health and treatment prognosis of teeth. Consequently, numerous studies have been conduc-ted to explore strategies for its prevention and management, aiming not only to mitigate resorption but also to develop intelligent prevention and control systems. This article reviews the research progress of current major treatment methods, including pharmacotherapy, low-intensity pulsed ultrasound, photobiomodulation therapy, and artificial-intelligence-based prediction, with the aim of providing a theoretical foundation and practical insights for refining intervention strategies and ultimately contributing to the development of safer and more effective therapeutic approaches.

Key words: orthodontically induced root resorption, drug therapies, low-intensity pulsed ultrasound, photobiomo-dulation therapy

中图分类号: 

  • R783.5

表 1

不同药物减少正畸源性牙根吸收的治疗方案及治疗效果总结"

药物名称动物种类药物剂量给药时长给药方式正畸牙移动距离牙根吸收
表没食子儿茶素没食子酸酯[9]Wistar大鼠每天50或100 mg/kg14 d灌胃减小减小
青藤碱[10]Wistar大鼠每天20或 40 mg/kg14 d腹腔注射减小减小
雷公藤甲素[11]Wistar大鼠每天15或 30 μg/kg14 d腹腔注射减小减小
淫羊藿苷[12]Wistar大鼠每天2.5 mg/kg21 d灌胃未涉及减小
白藜芦醇[13]Wistar大鼠每天5或10 mg/kg14 d灌胃减小减小
黄芩苷[14]Wistar大鼠每2天250 mg/kg21 d腹腔注射无明显变化减小
达沙替尼+槲皮素[3]Wistar大鼠每周6.67 mg/kg达沙替尼、66.7 mg/kg槲皮素8 d或14 d灌胃减小减小
对乙酰氨基酚[17]Wistar大鼠每天10?mg/kg30 d灌胃无明显变化减小
洛索洛芬[18]Wistar大鼠每天1 mg/kg30 d灌胃无明显变化减小
美洛昔康[19]Fischer344 大鼠每天3 mg/kg25 d灌胃减小减小
阿仑膦酸钠[22]山羊每次1 mL126 d牙周膜注射未涉及减小
雷尼酸锶[23]Wistar大鼠每天900 mg/kg28 d灌胃减少减少
甲状旁腺激素[33]Wistar大鼠每天40 μg/kg7、14、28 d皮下注射未涉及减小
雌二醇[36]Wistar大鼠每天10 μg/kg7、14、28 d皮下注射未涉及减小

图 1

多种药物通过OPG/RANKL/RANK信号通路减少OIRR"

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