国际口腔医学杂志 ›› 2026, Vol. 53 ›› Issue (4): 496-502.doi: 10.7518/gjkq.2026126

• 种植专栏 • 上一篇    下一篇

逆行性种植体周炎病因与治疗的研究进展

夏溦瑶1(),王婧2,屈依丽1()   

  1. 1.口腔疾病防治全国重点实验室 国家口腔医学中心 口腔疾病国家临床医学研究中心 四川大学华西口腔医院修复Ⅱ科 成都 610041
    2.口腔疾病防治全国重点实验室 国家口腔医学中心 口腔疾病国家临床医学研究中心 四川大学华西口腔医院种植科 成都 610041
  • 收稿日期:2025-04-22 修回日期:2026-02-09 出版日期:2026-07-01 发布日期:2026-06-25
  • 通讯作者: 屈依丽
  • 作者简介:夏溦瑶,医师,硕士,Email:xwy20000615@163.com
  • 基金资助:
    四川省科技厅重点研发项目(2024YFFK0200);四川省自然科学基金青年项目(2024NSFSC1598)

Progress on etiology and treatment of retrograde peri-implantitis

Weiyao Xia1(),Jing Wang2,Yili Qu1()   

  1. 1.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics Ⅱ, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2025-04-22 Revised:2026-02-09 Online:2026-07-01 Published:2026-06-25
  • Contact: Yili Qu
  • Supported by:
    Key Research and Development Project, Science and Technology Department of Sichuan Province(2024YFFK0200);Youth Project of Sichuan Provincial Natural Science Foundation(2024NSFSC1598)

摘要:

逆行性种植体周炎(RPI)是发生于种植体根尖部的罕见生物并发症,表现为围绕种植体根尖部的类圆形或不规则的低密度影像,是种植体早期失败的重要原因之一。目前,RPI的病因与发病机制尚不完全明确。现有研究表明该疾病可能与细菌感染、骨灼伤和异物反应等多种因素有关,同时该疾病的治疗决策也尚无统一定论。因此本文主要通过回顾RPI的潜在病因与治疗策略,总结其防治要点,为临床上该疾病的预防和诊治提供参考。

关键词: 逆行性种植体周炎, 根尖周炎, 防治决策

Abstract:

Retrograde peri-implantitis (RPI) is an infrequent biological complication that occurs in the apical region of implants, presenting as a circular or irregular low-density image surrounding the implant apex. It is one of the most important causes of early implant failure. The etiology and pathogenesis of RPI remain incompletely understood. Studies have shown that it may be related to multiple factors, including bacterial infection, bone overheating, and foreign body reactions. Furthermore, the treatment for RPI is not standardized. In this article, the etiology and treatment of RPI are reviewed to provide a reference for the prevention and treatment of this disease in clinical practice.

Key words: retrograde peri-implantitis, apical periodontitis, prevention and treatment strategy

中图分类号: 

  • R781.4

图 1

邻牙牙髓感染或AP扩散的RPI影像学分型A、C:Ⅰ型,邻牙根尖投射影与种植体根尖部低密度暗影无直接联通;B、D:Ⅱ型,邻牙根尖透射影与种植体根尖部联通。"

图 2

RPI的治疗决策"

图 3

术前种植位点邻牙存在慢性根尖周病的处理"

[1] Quirynen M, Vogels R, Alsaadi G, et al. Predisposing conditions for retrograde peri-implantitis, and treatment suggestions[J]. Clin Oral Implants Res, 2005, 16(5): 599-608.
[2] Chan HL, Wang HL, Bashutski JD, et al. Retrograde peri-implantitis: a case report introducing an approach to its management[J]. J Periodontol, 2011, 82(7): 1080-1088.
[3] Di Murro B, Papi P, Di Murro C, et al. Correlation between endodontic pulpal/periapical disease and re-trograde peri-implantitis: a case series[J]. Aust Endod J, 2021, 47(2): 358-364.
[4] 曾文奕, 杜宇. 逆行性植体周炎的诊断、病因与防治[J]. 中华口腔医学杂志, 2022, 57(3): 302-306.
Zeng WY, Du Y. Diagnosis, etiology, prevention and treatment in retrograde peri-implantitis[J]. Chin J Stomatol, 2022, 57(3): 302-306.
[5] Quirynen M, Gijbels F, Jacobs R. An infected jawbone site compromising successful osseointegration[J]. Periodontol 2000, 2000, 33: 129-144.
[6] Sarmast ND, Wang HH, Sajadi AS, et al. Classification and clinical management of retrograde peri-implantitis associated with apical periodontitis: a proposed classification system and case report[J]. J Endod, 2017, 43(11): 1921-1924.
[7] Al-Ahmad A, Ameen H, Pelz K, et al. Antibiotic resistance and capacity for biofilm formation of diffe-rent bacteria isolated from endodontic infections associated with root-filled teeth[J]. J Endod, 2014, 40(2): 223-230.
[8] Nelson S, Thomas G. Bacterial persistence in den-toalveolar bone following extraction: a microbiological study and implications for dental implant treatment[J]. Clin Implant Dent Relat Res, 2010, 12(4): 306-314.
[9] Ayangco L, Sheridan PJ. Development and treatment of retrograde peri-implantitis involving a site with a history of failed endodontic and apicoectomy procedures: a series of reports[J]. Int J Oral Maxillofac Implants, 2001, 16(3): 412-417.
[10] Alssum LR, Alghofaily MM, Aleyiydi AS, et al. The incidence of retrograde peri-implantitis in a single university dental hospital training center: a retrospective analysis[J]. Medicina, 2023, 59(3): 560.
[11] Peñarrocha-Diago MA, Blaya-Tárraga JA, Menén-dez-Nieto I, et al. Implant survival after surgical treatment of early apical peri-implantitis: an ambispective cohort study covering a 20-year period[J]. Int J Oral Implantol, 2020, 13(2): 161-170.
[12] Peñarrocha-Oltra D, Blaya-Tárraga JA, Menéndez-Nieto I, et al. Factors associated with early apical peri-implantitis: a retrospective study covering a 20-year period[J]. Int J Oral Implantol, 2020, 13(1): 65-73.
[13] Burdurlu MÇ, Dagasan VÇ, Tunç O, et al. Retrograde peri-implantitis: evaluation and treatment protocols of a rare lesion[J]. Quintessence Int, 2021, 52(2): 112-121.
[14] Lefever D, Van Assche N, Temmerman A, et al. Aetiology, microbiology and therapy of periapical lesions around oral implants: a retrospective analysis[J]. J Clin Periodontol, 2013, 40(3): 296-302.
[15] Muñoz-Cámara D, Gilbel-Del Águila O, Pardo-Za-mora G, et al. Immediate post-extraction implants placed in acute periapical infected sites with immediate prosthetic provisionalization: a 1-year prospective cohort study[J]. Med Oral Patol Oral Cir Bucal, 2020, 25(6): e720-e727.
[16] Di Murro B, Canullo L, Pompa G, et al. Prevalence and treatment of retrograde peri-implantitis: a retrospective cohort study covering a 20-year period[J]. Clin Oral Investig, 2021, 25(7): 4553-4561.
[17] McAllister BS, Masters D, Meffert RM. Treatment of implants demonstrating periapical radiolucencies[J]. Pract Periodontics Aesthet Dent, 1992, 4(9): 37-41.
[18] Pistilli R, Canullo L, Menini M, et al. Retrograde peri-implantitis associated with residual cysts: 3 ca-se reports[J]. J Am Dent Assoc, 2020, 151(12): 956-961.
[19] Solomonov M, Via S, Dinur N, et al. Retrograde peri-implantitis: incidence and possible co-existing factors: a retrospective analysis[J]. Aust Dent J, 2022, 67(4): 340-343.
[20] Daubert D, Black RM, Chrepa V, et al. Endodontic peri-implant defects: a new disease entity[J]. J Endod, 2020, 46(3): 444-448.
[21] Zhou W, Han C, Li DH, et al. Endodontic treatment of teeth induces retrograde peri-implantitis[J]. Clin Oral Implants Res, 2009, 20(12): 1326-1332.
[22] 丁锋, 王蕾, 王悦, 等. 逆行性种植体周围炎动物建模方式初探[J]. 实用口腔医学杂志, 2019, 35(2): 201-204.
Ding F, Wang L, Wang Y, et al. Preliminary study on animal modeling of retrograde peri-implantitis[J]. J Pract Stomatol, 2019, 35(2): 201-204.
[23] 满毅, 黄定明. 美学区种植骨增量与邻牙慢性根尖周病的联合治疗策略(上): 应用基础及适应证[J]. 国际口腔医学杂志, 2022, 49(5): 497-505.
Man Y, Huang DM. Combined treatment strategy of oral implantology and endodontic microsurgery for bone augmentation and endodontic diseases in aesthetic area (part 1): application basis and indications[J]. Int J Stomatol, 2022, 49(5): 497-505.
[24] Mei F, Xie MR, Huang XF, et al. Porphyromonas gingivalis and its systemic impact: current status[J]. Pathogens, 2020, 9(11): 944.
[25] Ran SJ, Huang J, Liu B, et al. Enterococcus faecalis activates NLRP3 inflammasomes leading to increa-sed interleukin-1 beta secretion and pyroptosis of THP-1 macrophages[J]. Microb Pathog, 2021, 154: 104761.
[26] Salvi GE, Bosshardt DD, Lang NP, et al. Temporal sequence of hard and soft tissue healing around titanium dental implants[J]. Periodontol 2000, 2015, 68(1): 135-152.
[27] Biguetti CC, Cavalla F, Silveira EM, et al. Oral implant osseointegration model in C57Bl/6 mice: microtomographic, histological, histomorphometric and molecular characterization[J]. J Appl Oral Sci, 2018, 26: e20170601.
[28] Lavelle C, Wedgwood D. Effect of internal irrigation on frictional heat generated from bone drilling[J]. J Oral Surg, 1980, 38(7): 499-503.
[29] Roos-Jansåker AM, Renvert S, Egelberg J. Treatment of peri-implant infections: a literature review[J]. J Clin Periodontol, 2003, 30(6): 467-485.
[30] Nedir R, Bischof M, Pujol O, et al. Starch-induced implant periapical lesion: a case report[J]. Int J Oral Maxillofac Implants, 2007, 22(6): 1001-1006.
[31] Langer L, Langer B, Salem D. Unintentional root fragment retention in proximity to dental implants: a series of six human case reports[J]. Int J Periodontics Restorative Dent, 2015, 35(3): 305-313.
[32] Wassmann T, Kreis S, Behr M, et al. The influence of surface texture and wettability on initial bacterial adhesion on titanium and zirconium oxide dental implants[J]. Int J Implant Dent, 2017, 3(1): 32.
[33] Renvert S, Polyzois I, Claffey N. How do implant surface characteristics influence peri-implant disease[J]. J Clin Periodontol, 2011, 38(): 214-222.
[34] Amiel C, Ostertag A, Slama L, et al. BMD is reduced in HIV-infected men irrespective of treatment[J]. J Bone Miner Res, 2004, 19(3): 402-409.
[35] Erbe M, Rickerts V, Bauersachs RM, et al. Acquired protein C and protein S deficiency in HIV-infected patients[J]. Clin Appl Thromb Hemost, 2003, 9(4): 325-331.
[36] Shivakumar B, Mohamed J, Sudarsan S, et al. Retrograde peri-implantitis[J]. J Indian Soc Periodontol, 2010, 14(1): 57.
[37] Sussman HI. Periapical implant pathology[J]. J Oral Implantol, 1998, 24(3): 133-138.
[38] Waasdorp J, Reynolds M. Nonsurgical treatment of retrograde peri-implantitis: a case report[J]. Int J Oral Maxillofac Implants, 2010, 25(4): 831-833.
[39] Peñarrocha-Diago M, Boronat-Lopez A, García-Mira B. Inflammatory implant periapical lesion: etiology, diagnosis, and treatment: presentation of 7 cases[J]. J Oral Maxillofac Surg, 2009, 67(1): 168-173.
[40] Gong JM, Zhao RM, Yu ZH, et al. A novel histopathological classification of implant periapical lesion: a systematic review and treatment decision tree[J]. PLoS One, 2022, 17(12): e0277387.
[41] Gong JM, Al-Sosowa AA, Zhao RM, et al. Successful management of peri-implant infection from the endodontic lesion of adjacent natural tooth[J]. Case Rep Dent, 2023, 2023: 5034582.
[42] Balshi SF, Wolfinger GJ, Balshi TJ. A retrospective evaluation of a treatment protocol for dental implant periapical lesions: long-term results of 39 implant apicoectomies[J]. Int J Oral Maxillofac Implants, 2007, 22(2): 267-272.
[43] 满毅, 黄定明. 美学区种植骨增量与邻牙慢性根尖周病的联合治疗策略(下): 临床诊治流程及实践病例[J]. 国际口腔医学杂志, 2022, 49(6): 621-632.
Man Y, Huang DM. Combined treatment strategy of oral implantology and endodontics microsurgery (part 2): clinical protocol and practical cases[J]. Int J Stomatol, 2022, 49(6): 621-632.
[44] Wang J, Luo YL, Tan XL, et al. Horizontal bone augmentation of the edentulous area with simultaneous endodontic microsurgery of the adjacent tooth: a digitally-driven multidisciplinary case report with a 1-year follow-up[J]. Int J Oral Implantol, 2021, 14(4): 435-451.
[1] 张书旸, 胡顺佳怡, 戚琳珑, 梁筱瑶, 邓淑丽. 外伤年轻恒牙行牙髓再生治疗的研究进展[J]. 国际口腔医学杂志, 2025, 52(6): 738-747.
[2] 毛鸿晨,王铮,杨德琴. 牙龈卟啉单胞菌外膜囊泡在口腔疾病中的作用及其机制的研究进展[J]. 国际口腔医学杂志, 2024, 51(5): 608-615.
[3] 徐智博,孟秀萍. 粪肠球菌逃逸宿主免疫防御机制的研究进展[J]. 国际口腔医学杂志, 2023, 50(5): 613-617.
[4] 梁芷瑩,赵苑汐,朱嘉妮,苏勤. 288例前牙显微根尖手术临床资料的回顾性分析[J]. 国际口腔医学杂志, 2023, 50(2): 166-171.
[5] 满毅, 黄定明. 美学区种植骨增量与邻牙慢性根尖周病的联合治疗策略(上):应用基础及适应证[J]. 国际口腔医学杂志, 2022, 49(5): 497-505.
[6] 朱嘉妮,苏勤. 难治性根尖周炎根管内及根尖外菌群的研究现状[J]. 国际口腔医学杂志, 2022, 49(3): 283-289.
[7] 税钰森,吕潇颖,李静雅,杨燃. 粪肠球菌在口腔及全身系统性疾病中的致病相关因素及其机制的研究进展[J]. 国际口腔医学杂志, 2020, 47(2): 225-234.
[8] 崔钰嘉,孙建勋,周学东. 黄连素的生物学功能及治疗口腔疾病研究的进展[J]. 国际口腔医学杂志, 2020, 47(1): 115-120.
[9] 杨子,侯本祥. 持续性根尖周炎根管内外生物膜特性的研究进展[J]. 国际口腔医学杂志, 2019, 46(2): 238-243.
[10] 林冬佳, 彭志翔, 高燕. 粪肠球菌与巨噬细胞相互作用机制的研究进展[J]. 国际口腔医学杂志, 2018, 45(4): 433-438.
[11] 吕晶, 凌均棨. 根管定位数字化导板的研究进展[J]. 国际口腔医学杂志, 2018, 45(2): 233-238.
[12] 衣晓伟, 黄定明, 张岚. 糖尿病患者牙髓根尖周病的发病机制及临床管理[J]. 国际口腔医学杂志, 2018, 45(2): 214-218.
[13] 雷期音, 陈柯. 年轻恒牙牙髓再生的临床应用进展[J]. 国际口腔医学杂志, 2017, 44(3): 267-272.
[14] 高静,申静,张海峰,靳淑凤. 锥形束CT与根尖片对实验性根尖周炎根管治疗结果的评估[J]. 国际口腔医学杂志, 2016, 43(3): 292-294.
[15] 刘梦余 叶玲 汪成林. 白细胞介素-17及其在口腔疾病中的作用[J]. 国际口腔医学杂志, 2015, 42(6): 728-732.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 蔡霞,李成章. 前列腺素E_2受体EP亚型在牙周炎发病机制中的作用[J]. 国际口腔医学杂志, 2005, 32(06): 461 -462 .
[2] 聂盼 李婧 李伟. Activator 治疗骨性Ⅱ类畸形的临床应用[J]. 国际口腔医学杂志, 2011, 38(4): 380 -383 .
[3] 黄君斐,王敏. 全瓷修复体颜色效果的影响因素[J]. 国际口腔医学杂志, 2008, 35(S1): .
[4] 何苇, 卢胜军, 李承浩, 蒙田, 周京琳, 石冰. 不同剂量地塞米松对小鼠胚胎腭裂发生的影响[J]. 国际口腔医学杂志, 2009, 36(3): 270 -272 .
[5] 冯正虎, 李春青, 王凌, 韩冰, 聂红兵, 苏雪莲. 血管内皮生长因子-C 在不同浸润方式的舌鳞状细胞癌中的表达[J]. 国际口腔医学杂志, 2011, 38(1): 7 -9 .
[6] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .
[7] 邓末宏 龙星. 声电图在颞下颌关节杂音分析中的应用[J]. 国际口腔医学杂志, 2004, 31(03): 223 -225 .
[8] 李励芸 魏文佳 孟翔峰. 长期水储存对玻璃陶瓷与牙本质间树脂粘接界面的影响[J]. 国际口腔医学杂志, 2013, 40(4): 436 -439 .
[9] 李高华,彭菊香,钟建莉,刘建国,管晓燕,徐宇红,丰雷,苏牧,黄瑾. 实验性正畸牙齿移动距离测量方法的对比研究[J]. 国际口腔医学杂志, 2010, 37(4): 400 -402 .
[10] 宋文婷1 刘光涛2 隋秋丽3 陈渊3 葛林3 林梅3. 音乐对味觉辨别阈的影响[J]. 国际口腔医学杂志, 2013, 40(4): 459 -461 .