国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (6): 738-747.doi: 10.7518/gjkq.2025065

• 牙体牙髓病学专栏 • 上一篇    下一篇

外伤年轻恒牙行牙髓再生治疗的研究进展

张书旸1(),胡顺佳怡2,戚琳珑1,梁筱瑶1,邓淑丽1()   

  1. 1.浙江大学医学院附属口腔医院;浙江大学口腔医学院 浙江省口腔疾病临床医学研究中心;浙江省口腔生物医学研究重点实验室 浙江大学癌症研究院;口腔生物材料与器械浙江省工程研究中心 杭州 310000
    2.浙江中医药大学口腔医学院 杭州 310053
  • 收稿日期:2024-06-30 修回日期:2025-02-24 出版日期:2025-11-01 发布日期:2025-10-23
  • 通讯作者: 邓淑丽
  • 作者简介:张书旸，住院医师，硕士，Email：22218752@zju.edu.cn
  • 基金资助:
    浙江省“尖兵”“领雁”研发攻关计划(2022C03060)

Research progress in regenerative endodontics for traumatized immature permanent teeth

Shuyang Zhang1(),Shunjiayi Hu2,Linlong Qi1,Xiaoyao Liang1,Shuli Deng1()   

  1. 1.Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China
    2.School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China
  • Received:2024-06-30 Revised:2025-02-24 Online:2025-11-01 Published:2025-10-23
  • Contact: Shuli Deng
  • Supported by:
    Grants from "Pioneer" and "Leading Goose" Research and Development Program in Zhejiang Province(2022C03060)

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摘要：

外伤易引起年轻恒牙发生牙髓坏死及根尖周炎，而导致牙根停止发育。此时的年轻恒牙因其开放的根尖孔、薄根管壁及短牙根等特点影响其在口腔内的存留和功能行使，牙髓再生治疗是能够促进年轻恒牙牙根继续发育的治疗方法，对根尖周病变的愈合、根尖孔的闭合、牙根的增长及根管壁的增厚，均有显著临床意义。尽管多数研究报道其有较高的成功率，但仍存在牙根持续性吸收和根尖周持续性炎症等失败可能。本文拟从外伤年轻恒牙的治疗过程、生物学依据、临床治疗效果及治疗失败病例分析等方面对外伤年轻恒牙行牙髓再生治疗进行系统综述，为临床医生提供理论依据。

关键词: 牙外伤, 年轻恒牙, 牙髓坏死及根尖周炎, 牙髓再生治疗

Abstract:

Trauma can easily lead to pulp necrosis and periapical periodontitis in immature permanent teeth, and the roots then stop developing. At this time, immature permanent teeth are characterized by open apical foramina, thin root canal walls, and short roots that affect their retention and function in the oral cavity. Regenerative endodontics is a treatment that can promote the continuous development of the roots of immature permanent teeth. This procedure has significant clinical significance in the healing of periapical lesions and the closure of apical foramina as well as in increasing the length of the roots and the thickness of the root canal walls. Although most studies reported a high success rate for this procedure, failure may occur, including persistent root resorption and persistent periapical inflammation. In this paper, we provide a systematic review of regenerative endodontics for traumatized immature permanent teeth in terms of the treatment process, biological rationale, clinical outcomes, and analysis of cases of treatment failure to provide theoretical basis for clinicians.

Key words: dental trauma, immature permanent teeth, pulp necrosis and periapical periodontitis, regenerative endodontics procedure

中图分类号: 

  • R781.05
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