国际口腔医学杂志

国际口腔医学杂志 ›› 2026, Vol. 53 ›› Issue (3): 388-400.doi: 10.7518/gjkq.2026106

• 综述 • 上一篇    

骨关节炎状态对药物渗透的影响及改善策略

陈浩哲(),杨茂莹,祝颂松,姜楠()   

  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 口腔疾病国家临床医学研究中心 四川大学华西口腔医院正颌及关节外科 成都 610041
  • 收稿日期:2025-05-29 修回日期:2025-08-11 出版日期:2026-05-01 发布日期:2026-04-24
  • 通讯作者: 姜楠
  • 作者简介:陈浩哲，助理研究员，博士，Email：hz_chen@scu.edu.cn
  • 基金资助:
    国家自然科学基金(82301112);四川省科学技术厅青年基金项目(2024NSFSC1592);成都市技术创新研发项目(2024-YF05-00001-SN);四川大学华西口腔医院资助临床研究项目(LCYJ-ZD-202302)

Impact of osteoarthritis status on drug penetration and strategies for improvement

Haozhe Chen(),Maoying Yang,Songsong Zhu,Nan Jiang()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthognathic and Temporomandibular Joint Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2025-05-29 Revised:2025-08-11 Online:2026-05-01 Published:2026-04-24
  • Contact: Nan Jiang
  • Supported by:
    National Natural Science Foundation of China(82301112);Youth Fund Project of Sichuan Provincial Department of Science and Technology(2024NSFSC1592);Chengdu Technology Innovation R&D Project(2024-YF05-00001-SN);Clinical Research Project Funded by West China Hospital of Stomatology, Sichuan University(LCYJ-ZD-202302)

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摘要：

关节腔注射治疗作为骨关节炎（OA）的一种治疗方式，其有效应用要求药物能够深入渗透软骨，因此软骨的渗透性成为了药物作用的关键。然而OA状态下软骨固有的低渗结构发生变化，进一步影响了关节腔注射的药物渗透。本文综述了包括透明软骨和纤维软骨在内的不同类型软骨及不同软骨区域的结构特性以及OA引起的软骨变化对药物扩散可能产生的影响，并以此为基础进一步综述了增强药物渗透能力的关节内药物递送策略及存在的问题，旨在为 OA 治疗领域的研究与临床实践提供新的思路，推动关节内药物递送系统的迭代升级与研发工作。

关键词: 软骨渗透性, 骨关节炎, 关节腔注射, 软骨靶向, 药物递送

Abstract:

As a treatment approach for osteoarthritis (OA), intra-articular injection requires drugs to deeply penetrate the cartilage for effective treatment. Thus, cartilage permeability is crucial for drugs to take effect. However, the natural low-permeability structure of cartilages changes in OA, further affecting drug penetration. This study reviews the structu-ral traits of healthy hyaline cartilage and fibrocartilage (noncalcified and calcified regions) and analyses OA-induced permeability changes. Intra-articular drug delivery strategies for enhancing penetration and their existing problems are further explored. This work aims to offer a new insight for research and clinical practice in OA treatment and to promote the development of intra-articular drug delivery systems for OA.

Key words: cartilage penetration, osteoarthritis, intra-articular injection, cartilage targeting, drug delivery

中图分类号: 

  • R782.6

图 1

软骨的生理与OA病理结构"

图 2

增强软骨渗透的递送策略"

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