Abstract: Objective To discuss the reason from which oral cavity Saccharomyces albicans get sick for being infected from the angle of looking at the human immunodeficiency virus（HIV）-infected persons and analyzing the saliva secreted immunoglobulin A（sIgA） content and the Saccharomyces albicans adherency change rates. Methods To exam saliva sIgA content, to observe the Saccharomyces albicans standard and clinical separation in content of sIgA that is not contained in the sIgA environment and the buccal mucosa epithelial cell adherency rate by the sticky experiment, and to compare the differences of oral cavity Saccharomyces albicans adherency rate between HIV/acquired immunodeficiency syndrome（AIDS） group and healthy control group. Results The sIgA content in HIV/AIDS group is lower than that of the healthy group（P＜0.05）. In the environment of sIgA content, the ensemble average of Saccharomyces albicans stick rate（standard and clinical separation） is lower than that of the non-sIgA environment, and therefore the differences between the two groups do have the statistics significance（P=0.001）. In the environment of sIgA content, Saccharomyces albicans adherency rate in the oral cavity of the HIV/AIDS group is higher than that of the healthy control group（P＜0.005）. Conclusion The saliva sIgA content change and the Saccharomyces albicans adherency change in the HIV/AIDS group easily infected by the oral candidiasis are interdependent and their relationship is rather close.