国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (1): 103-107.doi: 10.7518/gjkq.2017.01.021
刘诗雨,何金枝,李明云
Liu Shiyu, He Jinzhi, Li Mingyun.
摘要: 白假丝酵母菌是一种革兰阳性真菌微生物,广泛存在于健康人的上呼吸道、肠道和阴道中,当其与宿主处于共生状态时不会引起疾病,反之则由酵母相转化为菌丝相,导致口腔黏膜感染,引起口腔龋坏病变。在龋病患者的口腔生物膜上,变异链球菌和白假丝酵母菌之间可能存在某种互动关系并介导龋病的发展。白假丝酵母菌可与格氏链球菌紧密地黏附在一起,即格氏链球菌细胞壁表面的多糖是白假丝酵母菌黏附的受体之一。格氏链球菌可缓解群体感应机制对白假丝酵母菌菌丝相形成和生物膜生长的抑制作用,从而增加菌斑生物膜的量。本文就白假丝酵母菌,白假丝酵母菌与龋病的相关性,白假丝酵母菌与变异链球菌、格氏链球菌和其他口腔细菌相互作用参与龋病的发生发展的可能机制等研究进展作一综述,旨在为以后的临床研究提供思路和参考。
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