国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (6): 699-704.doi: 10.7518/gjkq.2019103

• 综述 • 上一篇    下一篇

定量光导荧光技术在龋病及牙周疾病诊治中的应用

陈艳艳,彭显,周学东,程磊()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科 成都 610041
  • 收稿日期:2019-03-12 修回日期:2019-08-05 出版日期:2019-11-01 发布日期:2019-11-14
  • 通讯作者: 程磊
  • 作者简介:陈艳艳,硕士,Email： chenyanyandentist@163.com
  • 基金资助:
    国家自然科学基金面上项目(81870759)

Application of quantitative light-induced fluorescence in the clinical treatment of caries and periodontal diseases

Chen Yanyan,Peng Xian,Zhou Xuedong,Cheng Lei()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-03-12 Revised:2019-08-05 Online:2019-11-01 Published:2019-11-14
  • Contact: Lei Cheng
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81870759)

RichHTML

21

PDF (PC)

833

摘要：

定量光导荧光（QLF）技术自面世以来,就有文章研究其检测及定量牙体组织脱矿情况的能力。随着技术的发展,QLF技术在龋病的诊断及防治中的应用不断被开发。除此以外,QLF还能检测及定量菌斑激发出的红色荧光,红色荧光被认为可能与牙周疾病及菌斑的致龋能力有关。本文就QLF技术在龋病及牙周疾病诊治中的应用作一综述。

关键词: 定量光导荧光技术, 牙菌斑, 龋病, 龋病风险, 牙周疾病

Abstract:

Since quantitative light-induced fluorescence (QLF) was invented, it has been applied in detection and quantification of incipient caries. With the development of technology, the clinical application of QLF has been continuously developed. Also, it can detect and quantify the red fluorescence from plaque, which is thought related to periodontal diseases and the cariogenic ability of plaque. This article reviewed the most recent findings about the clinical application of QLF in caries and periodontal diseases.

Key words: quantitative light-induced fluorescence, dental plaque, caries, caries risk, periodontal diseases

中图分类号: 

  • R781.05

表 1

两代设备比较"

设备 图像特点 分析参数 优缺点
InspektorTM QLF Pro 健康牙体组织：绿色
脱矿牙体组织：暗灰色
菌斑：亮红色		 ΔF、A、ΔQ 优点：历史较悠久,其同于检测牙体脱矿情况的能力已有较多临床试验验证
缺点：图像中正常牙体组织表现为绿色,不利于图像分析;图像较不清晰,分辨率较低;检测红色荧光的灵敏度较差
QLF-D BiluminatorTM 健康牙体组织：白色
龋损牙体组织：黑色
菌斑：红色		 ΔF、A和ΔQ;R/G、ΔR和AΔR 优点：图像中正常牙体组织呈现为牙色,更符合人类视觉习惯;图像较清晰,分辨率高;更灵敏地检测及定量红色荧光
缺点：其检测牙体脱矿情况的能力还需更多临床试验验证;红色荧光的临床应用正在研究阶段
[1] Tatano R, Berkels B, Ehrlich EE , et al. Spatial agreement of demineralized areas in quantitative light-induced fluorescence images and digital photographs[J]. Dentomaxillofac Radiol, 2018,47(8):20180099.
[2] Abdulkareem EH, Memarzadeh K, Allaker RP , et al. Anti-biofilm activity of zinc oxide and hydroxyapatite nanoparticles as dental implant coating materials[J]. J Dent, 2015,43(12):1462-1469.
[3] Korkmaz YN, Yagci A . Comparing the effects of three different fluoride-releasing agents on white spot lesion prevention in patients treated with full coverage rapid maxillary expanders[J]. Clin Oral Investig, 2019,23(8):3275-3285.
[4] Hope CK, de Josselin de Jong E, Field MR , et al. Photobleaching of red fluorescence in oral biofilms[J]. J Periodontal Res, 2011,46(2):228-234.
[5] de Josselin de Jong E, Higham SM, Smith PW , et al. Quantified light-induced fluorescence, review of a diagnostic tool in prevention of oral disease[J]. J Appl Phys, 2009,105(10):102031.
[6] Felix Gomez G, Eckert GJ, Ferreira Zandona A . Oran- ge/red fluorescence of active caries by retrospective quantitative light-induced fluorescence image analysis[J]. Caries Res, 2016,50(3):295-302.
[7] Thurnheer T, Belibasakis GN . Effect of sodium fluoride on oral biofilm microbiota and enamel demineralization[J]. Arch Oral Biol, 2018,89:77-83.
[8] Restrepo M, Bussaneli DG, Jeremias F , et al. Control of white spot lesion adjacent to orthodontic bracket with use of fluoride varnish or chlorhexidine gel[J]. ScientificWorldJournal, 2015,2015:218452.
[9] Gokce G, Savas S, Kucukyilmaz E , et al. Effects of toothpastes on white spot lesions around orthodontic brackets using quantitative light-induced fluorescence (QLF): an in vitro study[J]. J Orofac Orthop, 2017,78(6):480-486.
[10] Iijima Y . Early detection of white spot lesions with digital camera and remineralization therapy[J]. Aust Dent J, 2008,53(3):274-280.
[11] Kim HE, Kim BI . Prediction of early caries prognosis after fluoride application based on the severity of lesions: an in situ study[J]. Photodiagnosis Photodyn Ther, 2018,23:45-49.
[12] Beerens MW, Ten Cate JM, Buijs MJ , et al. Long-term remineralizing effect of MI Paste Plus on regression of early caries after orthodontic fixed appliance treatment: a 12-month follow-up randomized controlled trial[J]. Eur J Orthod, 2018,40(5):457-464.
[13] Durmusoglu O, Tağtekin DA, Yanikoğlu F . Clinical evaluation of demineralization and remineralization of intact root surface lesions in the clinic by a quantitative light-induced fluorescence system[J]. Lasers Med Sci, 2012,27(2):397-402.
[14] Lee HS, Kim SK, Park SW , et al. Caries detection and quantification around stained pits and fissures in occlusal tooth surfaces with fluorescence[J]. J Biomed Opt, 2018,23(9):1-7.
[15] Rodrigues JA, Hug I, Diniz MB , et al. Performance of fluorescence methods, radiographic examination and ICDAS Ⅱ on occlusal surfaces in vitro[J]. Caries Res, 2008,42(4):297-304.
[16] Kühnisch J, Ifland S, Tranaeus S , et al. In vivo detection of non-cavitated caries lesions on occlusal surfaces by visual inspection and quantitative light-in- duced fluorescence[J]. Acta Odontol Scand, 2007,65(3):183-188.
[17] Pereira AC, Eggertsson H, Martinez-Mier EA , et al. Validity of caries detection on occlusal surfaces and treatment decisions based on results from multiple caries-detection methods[J]. Eur J Oral Sci, 2009,117(1):51-57.
[18] Jung EH, Lee ES, Jung HI , et al. Development of a fluorescence-image scoring system for assessing noncavitated occlusal caries[J]. Photodiagnosis Photodyn Ther, 2018,21:36-42.
[19] Pereira AC, Eggertsson H, González-Cabezas C , et al. Quantitative light-induced fluorescence (QLF) in relation to other technologies and conventional methods for detecting occlusal caries in permanent teeth[J]. Braz J Oral Sci, 2011,10(1):27-32.
[20] Alammari MR, Smith PW, de Josselin de Jong E, et al. Quantitative light-induced fluorescence (QLF): a tool for early occlusal dental caries detection and supporting decision making in vivo[J]. J Dent, 2013,41(2):127-132.
[21] Yoon HI, Yoo MJ, Park EJ . Detection of proximal caries using quantitative light-induced fluorescence-digital and laser fluorescence: a comparative study[J]. J Adv Prosthodont, 2017,9(6):432-438.
[22] Ko HY, Kang SM, Kim HE , et al. Validation of quantitative light-induced fluorescence-digital (QLF- D) for the detection of approximal caries in vitro[J]. J Dent, 2015,43(5):568-575.
[23] Ando M, González-Cabezas C, Isaacs RL , et al. Evaluation of several techniques for the detection of secondary caries adjacent to amalgam restorations[J]. Caries Res, 2004,38(4):350-356.
[24] Lee MA, Kang SM, Kim SY , et al. Fluorescence change of Fusobacterium nucleatum due to Porphyromonas gingivalis[J]. J Microbiol, 2018,56(9):628-633.
[25] Khudanov B, Jung HI, Kahharova D , et al. Effect of an oral health education program based on the use of quantitative light-induced fluorescence technology in Uzbekistan adolescents[J]. Photodiagnosis Photodyn Ther, 2018,21:379-384.
[26] Volgenant CM, Hoogenkamp MA, Krom BP , et al. Red and green fluorescence from oral biofilms[J]. PLoS One, 2016,11(12):e0168428.
[27] van der Veen MH, Volgenant CM, Keijser B , et al. Dynamics of red fluorescent dental plaque during experimental gingivitis—a cohort study[J]. J Dent, 2016,48:71-76.
[28] Ku HM, Jun MK, Kim JH , et al. Explaining the red fluorescence evident on the surface of failed dental implants: case reports[J]. Implant Dent, 2016,25(3):445-449.
[29] Volgenant CM, van der Veen MH, de Soet JJ , et al. Effect of metalloporphyrins on red autofluorescence from oral bacteria[J]. Eur J Oral Sci, 2013,121(3 Pt 1):156-161.
[30] Lee ES, Kang SM, Ko HY , et al. Association between the cariogenicity of a dental microcosm bio-film and its red fluorescence detected by Quantitative Light-induced Fluorescence-Digital (QLF-D)[J]. J Dent, 2013,41(12):1264-1270.
[31] Kim YS, Lee ES, Kwon HK , et al. Monitoring the maturation process of a dental microcosm biofilm using the Quantitative Light-induced Fluorescence-Digital (QLF-D)[J]. J Dent, 2014,42(6):691-696.
[32] Smith RN, Brook AH, Elcock C . The quantification of dental plaque using an image analysis system: re- liability and validation[J]. J Clin Periodontol, 2001,28(12):1158-1162.
[33] Han SY, Kim BR, Ko HY , et al. Assessing the use of Quantitative Light-induced Fluorescence-Digital as a clinical plaque assessment[J]. Photodiagnosis Photodyn Ther, 2016,13:34-39.
[34] Han SY, Kim BR, Ko HY , et al. Validity and reliability of autofluorescence-based quantification method of dental plaque[J]. Photodiagnosis Photodyn Ther, 2015,12(4):587-591.
[35] Volgenant CMC, Fernandez Y, Mostajo M, Rosema NAM, et al. Comparison of red autofluorescing plaque and disclosed plaque-a cross-sectional study[J]. Clin Oral Investig, 2016,20(9):2551-2558.
[36] Coulthwaite L, Pretty IA, Smith PW , et al. QLF is not readily suitable for in vivo denture plaque assessment[J]. J Dent, 2009,37(11):898-901.
[1] 高若凡,夏斌. 基于慢性疾病管理理念的重度低龄儿童龋管理方法[J]. 国际口腔医学杂志, 2023, 50(3): 341-346.
[2] 龚涛,李雨庆,周学东. 变异链球菌糖转运及其调控机制的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 506-510.
[3] 李姗姗,杨芳. 变异链球菌与白色念珠菌相互作用在龋病发生中的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 392-396.
[4] 朱锦怡,樊琪,周媛,邹静,黄睿洁. 唾液蛋白作为低龄儿童龋预测标志物的研究进展[J]. 国际口腔医学杂志, 2022, 49(2): 212-219.
[5] 刘程程, 丁一. 妊娠期常见口腔感染性疾病的临床诊疗和管理策略[J]. 国际口腔医学杂志, 2021, 48(6): 621-628.
[6] 黄晓慧,祁本婷,杨洁,刘玉,孙卫斌. 机械性邻面菌斑控制措施对牙周非手术治疗效果影响的系统评价[J]. 国际口腔医学杂志, 2021, 48(6): 656-663.
[7] 黄培勍,彭显,徐欣. 口腔挥发性硫化物的产生与针对性防治的研究进展[J]. 国际口腔医学杂志, 2021, 48(5): 592-599.
[8] 范宇,程磊. 吸烟影响口腔微环境及其在龋病进展中的作用[J]. 国际口腔医学杂志, 2021, 48(5): 609-613.
[9] 陈亮,丁一,孟姝. 宿主调节治疗在牙周病治疗中的研究进展[J]. 国际口腔医学杂志, 2020, 47(6): 706-710.
[10] 杨志雷,刘宝盈. 龋病牙菌斑微生态研究进展[J]. 国际口腔医学杂志, 2020, 47(5): 506-514.
[11] 崔钰嘉,孙建勋,周学东. 黄连素的生物学功能及治疗口腔疾病研究的进展[J]. 国际口腔医学杂志, 2020, 47(1): 115-120.
[12] 朱博文,陈立妹,郭竹玲. NLRP3炎性小体在牙周疾病中的研究进展[J]. 国际口腔医学杂志, 2019, 46(4): 450-455.
[13] 王晓波,林世耀,李霞. 母亲与儿童龋病关系的研究进展[J]. 国际口腔医学杂志, 2019, 46(4): 469-474.
[14] 王静,王艳,王川东,黄睿洁,田燕,胡玮,邹静. 甘草及其提取物在防治口腔感染相关疾病中的应用[J]. 国际口腔医学杂志, 2018, 45(5): 546-552.
[15] 丁杰, 宋光泰. 微创技术在儿童龋病治疗中的应用[J]. 国际口腔医学杂志, 2018, 45(4): 473-479.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[3] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 孟姝,吴亚菲,杨禾. 伴放线放线杆菌产生的细胞致死膨胀毒素及其与牙周病的关系[J]. 国际口腔医学杂志, 2005, 32(06): 458 -460 .
[8] 费晓露,丁一,徐屹. 牙周可疑致病菌对口腔黏膜上皮的粘附和侵入[J]. 国际口腔医学杂志, 2005, 32(06): 452 -454 .
[9] 赵兴福,黄晓晶. 变形链球菌蛋白组学研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .
[10] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .