国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (4): 466-472.doi: 10.7518/gjkq.2025038

• 牙体牙髓专栏 • 上一篇    下一篇

天然植物提取物作为根管冲洗剂的研究进展

齐斌(),徐海明,卢志山()   

  1. 滨州医学院附属烟台市口腔医院牙体牙髓科 烟台 264008
  • 收稿日期:2024-01-31 修回日期:2024-08-23 出版日期:2025-07-01 发布日期:2025-06-20
  • 通讯作者: 卢志山
  • 作者简介:齐斌，住院医师，硕士，Email：qibinchn@163.com

Progress in research on natural plant extracts as root canal irritants

Bin Qi(),Haiming Xu,Zhishan Lu()   

  1. Dept. of Endodontics, Yantai Stomatological Hospital Affiliated to Binzhou Medical College, Yantai 264008, China
  • Received:2024-01-31 Revised:2024-08-23 Online:2025-07-01 Published:2025-06-20
  • Contact: Zhishan Lu

RichHTML

0

PDF (PC)

9

摘要：

“感染控制”是根管治疗的核心，然而根管系统结构错综复杂，单纯依靠机械预备方法并不能达到彻底的根管清创，往往需要结合根管冲洗等化学预备方法。化学根管冲洗剂存在着诸如细胞毒性、影响牙本质的理化性能等缺点。近年来，天然植物提取物作为根管冲洗剂，因其具有容易获得、毒性小和成本低廉、具有抗菌性能等特点而受到关注。本文对目前新型天然植物提取物根管冲洗剂的分类、体外研究、体内研究及新的使用策略等作一综述，以期为临床工作提供参考。

关键词: 根管治疗, 根管冲洗剂, 植物提取物

Abstract:

“Infection control” is the core of root canal treatment. Owing to the intricate three-dimensional structure of the root canal system, relying on mechanical preparation methods cannot achieve thorough root canal debridement and often requires a combination of chemical preparation methods, such as root canal irrigation. However, chemical root canal irritants have drawbacks, such as cytotoxicity and adverse effects on the physicochemical properties of dentin. Natural plant extracts as root canal irritants have attracted considerable interest because they are widely available and have low toxicity, low cost, and antibacterial properties. This article provides a review of the classification of natural plant extracts, in vitro and in vivo studies, and novel strategies for using natural plant extracts as root canal irritants, providing a refe-rence for their clinical application.

Key words: root canal therapy, root canal irrigants, natural plant extracts

中图分类号: 

  • R781.05

《口腔颌面头颈肿瘤临床实践手册》出版发行"

[1] Salem AS, Tompkins GR, Cathro PR. Alkaline tole-rance and biofilm formation of root canal isolates of Enterococcus faecalis: an in vitro study[J]. J Endod, 2022, 48(4): 542-547.e4.
[2] Siqueira JF Jr, Pérez AR, Marceliano-Alves MF, et al. What happens to unprepared root canal walls: a correlative analysis using micro-computed tomography and histology/scanning electron microscopy[J]. Int Endod J, 2018, 51(5): 501-508.
[3] 吴昊泽, 李娜, 程小刚, 等. 根管冲洗消毒药物的研究进展[J]. 口腔疾病防治, 2023, 31(10): 756-760.
Wu HZ, Li N, Cheng XG, et al. Research progress on root canal irrigation disinfection drugs[J]. J Dent Prevent Treat, 2023, 31(10): 756-760.
[4] Cai C, Chen X, Li Y, et al. Advances in the role of sodium hypochlorite irrigant in chemical preparation of root canal treatment[J]. Biomed Res Int, 2023, 2023: 8858283.
[5] Kanagasingam S, Blum IR. Sodium hypochlorite extrusion accidents: management and medico-legal considerations[J]. Prim Dent J, 2020, 9(4): 59-63.
[6] Nogo-Živanović D, Kanjevac T, Bjelović L, et al. The effect of final irrigation with MTAD, QMix, and EDTA on smear layer removal and mineral content of root canal dentin[J]. Microsc Res Tech, 2019, 82(6): 923-930.
[7] 梁宇红, 岳林. 根管治疗技术之根管的化学预备和消毒[J]. 中华口腔医学杂志, 2019, 54(11): 788-792.
Liang YH, Yue L. Root canal treatment: key steps in root canal irrigation and medicaments[J]. Chin J Stomatol, 2019, 54(11): 788-792.
[8] Kale PP, Raut AW. A proposed classification system for herbal endodontic irrigants[J]. J Conserv Dent, 2021, 24(3): 293-295.
[9] Gulati RK, Jain N, Singh A, et al. Comparative eva-luation of the antimicrobial efficacy of chemical and phytomedicinal agents when used as intracanal irri-gants: an in vitro study[J]. Cureus, 2023, 15(11): e48754.
[10] Abdollahi-Mansoorkhani HR, Soleimani F, Mahmoudi F. A multi-criteria approach for comparison of ginger extract and conventional irrigants in root canal treatment[J]. Cureus, 2022, 14(9): e29327.
[11] Mokhtari H, Eskandarinezhad M, Barhaghi MS, et al. Comparative antibacterial effects of ginger and marjoram extract versus conventional irrigants on mature Enterococcus faecalis biofilms: an in vitro study[J]. J Clin Exp Dent, 2023, 15(4): e304-e310.
[12] Gupta D, Kamat S, Hugar S, et al. A comparative evaluation of the antibacterial efficacy of Thymus vulgaris, Salvadora persica, Acacia nilotica, Calendula arvensis, and 5% sodium hypochlorite against Enterococcus faecalis: an in-vitro study[J]. J Conserv Dent, 2020, 23(1): 97-101.
[13] Tahir A, Ur-Rehman Qazi F, Choudhry Z, et al. Influence of Sapindus mukorossi extract in comparison to 17% EDTA as final root canal irrigant on the sealer penetration and microleakage of dentinal tubules[J]. Eur Rev Med Pharmacol Sci, 2023, 27(7): 2724-2732.
[14] Venkataram V, Gokhale ST, Kenchappa M, et al. Effectiveness of chamomile (Matricaria recutita L.), MTAD and sodium hypochlorite irrigants on smear layer[J]. Eur Arch Paediatr Dent, 2013, 14(4): 247-252.
[15] Murray PE, Farber RM, Namerow KN, et al. Evalua-tion of Morinda citrifolia as an endodontic irrigant[J]. J Endod, 2008, 34(1): 66-70.
[16] Agnihotri A, Jhamb S, Shrama U, et al. Azadirachta indica A. juss, Morinda citrifolia L. and Triphala as herbal endodontic irrigants: a scoping review[J]. Ayu, 2020, 41(3): 148-158.
[17] Hosny NS, El Khodary SA, El Boghdadi RM, et al. Effect of Neem (Azadirachta indica) versus 2.5% sodium hypochlorite as root canal irrigants on the intensity of post-operative pain and the amount of endotoxins in mandibular molars with necrotic pulps: a randomized controlled trial[J]. Int Endod J, 2021, 54(9): 1434-1447.
[18] Setia R, Bajaj N, Bhola M, et al. Comparative eva-luation of smear layer removal efficacy of neem leaf extract, propolis, and orange oil when used as en-dodontic irrigants: an in vitro scanning electron microscopic study[J]. Contemp Clin Dent, 2023, 14(2): 128-134.
[19] Mehta N, Gupta A, Mahesh S, et al. Comparative evaluation of antibacterial efficacy of Allium sativum extract, aqueous ozone, diode laser, and 3% sodium hypochlorite in root canal disinfection: an in vivo study[J]. J Conserv Dent, 2020, 23(6): 577-582.
[20] Navayath M, Ramesh SR, Kalaiselvam R, et al. Evaluation of nanomagnesium oxide in combination with garlic extract as an endodontic irrigant: an in vitro study[J]. J Contemp Dent Pract, 2023, 24(7): 459-466.
[21] Reshma Raj VP, Varma RB, Sureshkumar J, et al. Comparison of cytotoxicity and smear layer remo-val efficacy of triphala (an Indian ayurvedic herbal formulation) and 5.25% sodium hypochlorite as root canal irrigants: an in vitro study[J]. J Indian Soc Pedod Prev Dent, 2020, 38(4): 343-349.
[22] Mukherjee M, Kalita T, Barua P, et al. Efficacy of smear layer removal of human teeth root canals u-sing herbal and chemical irrigants: an in vitro study[J]. Cureus, 2023, 15(6): e40467.
[23] Nasim I, Jabin Z, Kumar SR, et al. Green synthesis of calcium hydroxide-coated silver nanoparticles u-sing Andrographis paniculata and Ocimum sanctum Linn. leaf extracts: an antimicrobial and cytotoxic activity[J]. J Conserv Dent, 2022, 25(4): 369-374.
[24] Mali S, Singla S, Tyagi P, et al. Comparative evaluation of the efficacy of different herbal irrigants on the removal of smear layer of primary teeth: a scanning electron microscopy study[J]. J Indian Soc Pedod Prev Dent, 2020, 38(4): 374-380.
[25] 孙佳, 韩伟, 张疏影, 等. 穿心莲纳米乳液用于根管冲洗的清洁性实验研究[J]. 口腔医学研究, 2022, 38(5): 459-464.
Sun J, Han W, Zhang SY, et al. Cleaning efficacy of andrographis paniculata nanoemulsion irrigant on root canals[J]. J Oral Sci Res, 2022, 38(5): 459-464.
[26] Güçlüer Ö, Akarsu E, Yavuz E, et al. Human pulp tissue dissolution ability of different extracts of Sapindus mukorossi: an in vitro study[J]. Chin Herb Med, 2020, 12(2): 178-182.
[27] Farooq A, Rahman Qazi FU, Siddiqui J, et al. Comparison of an experimental root canal irrigant (Sapindus mukorossi) and ethylenediaminetetraacetic acid on microhardness of human dentin[J]. J Ayub Med Coll Abbottabad, 2022, 34(4): 766-770.
[28] Kameri A, Haziri A, Hashani Z, et al. Antibacterial effect of Matricaria chamomilla L. extract against Enterococcus faecalis [J]. Clin Cosmet Investig Dent, 2023, 15: 13-20.
[29] 张岚, 李艳萍, 何丽娜, 等. 诺丽联合EDTA应用对牙本质机械性能的影响[J]. 口腔医学, 2023, 43(8): 690-696.
Zhang L, Li YP, He LN, et al. Effects of Morinda citrifolia combined with EDTA root canal irrigation on the mechanical properties of dentin[J]. Stomato-logy, 2023, 43(8): 690-696.
[30] Rafi Shaik M, Sharaf MAF, Li XP, et al. In vitro antimicrobial activity and comparison of the herbal extracts and sodium hypochlorite against primary plaque colonizers[J]. FEMS Microbiol Lett, 2021, 368(4): fnab017.
[31] Sinha DJ, Rani P, Vats S, et al. Comparative evaluation of fracture resistance among conventional versus herbal irrigants in root canal treated teeth: in vitro study[J]. Aust Endod J, 2023, 49(): 433-438.
[32] Birring OJ, Viloria IL, Nunez P. Anti-microbial efficacy of Allium sativum extract against Enterococcus faecalis biofilm and its penetration into the root dentin: an in vitro study[J]. Indian J Dent Res, 2015, 26(5): 477-482.
[33] Divia AR, Nair MG, Varughese JM, et al. A compara-tive evaluation of Morinda citrifolia, green tea polyphenols, and Triphala with 5% sodium hypochlorite as an endodontic irrigant against Enterococcus faecalis: an in vitro study[J]. Dent Res J (Isfahan), 2018, 15(2): 117-122.
[34] Subbiya A, Mahalakshmi K, Pushpangadan S, et al. Antibacterial efficacy of Mangifera indica L. kernel and Ocimum sanctum L. leaves against Enterococcus faecalis dentinal biofilm[J]. J Conserv Dent, 2013, 16(5): 454-457.
[35] Susila AV, Sai S, Sharma N, et al. Can natural irri-gants replace sodium hypochlorite? A systematic review[J]. Clin Oral Investig, 2023, 27(5): 1831-1849.
[36] Podar R, Kulkarni GP, Dadu SS, et al. In vivo antimicrobial efficacy of 6% Morinda citrifolia, Azadirachta indica, and 3% sodium hypochlorite as root canal irrigants[J]. Eur J Dent, 2015, 9(4): 529-534.
[37] Chandwani M, Mittal R, Chandak S, et al. Effectiveness of Morinda citrifolia juice as an intracanal irrigant in deciduous molars: an in vivo study[J]. Dent Res J (Isfahan), 2017, 14(4): 246-251.
[38] Alzohairy MA. Therapeutics role of Azadirachta indica (neem) and their active constituents in diseases prevention and treatment[J]. Evid Based Complement Alternat Med, 2016, 2016: 7382506.
[39] Siddique R, Ranjan M, Jose J, et al. Clinical quantitative antibacterial potency of garlic-lemon against sodium hypochlorite in infected root canals: a double-blinded, randomized, controlled clinical trial[J]. J Int Soc Prev Community Dent, 2020, 10(6): 771-778.
[40] Elheeny AAH. Allium sativum extract as an irrigant in pulpectomy of primary molars: a 12-month short-term evaluation[J]. Clin Exp Dent Res, 2019, 5(4): 420-426.
[41] Chhabra N, Gyanani H, Kamatagi L. Smear layer removal efficacy of combination of herbal extracts in two different ratios either alone or supplemented with sonic agitation: an in vitro scanning electron microscope study[J]. J Conserv Dent, 2015, 18(5): 374-378.
[42] Parolia A, Kumar H, Ramamurthy S, et al. Effect of propolis nanoparticles against Enterococcus faecalis biofilm in the root canal[J]. Molecules, 2021, 26(3): 715.
[43] Parolia A, Kumar H, Ramamurthy S, et al. Effectiveness of chitosan-propolis nanoparticle against Enterococcus faecalis biofilms in the root canal[J]. BMC Oral Health, 2020, 20(1): 339.
[44] Susan AC, Bharathraj AR, Praveen M, et al. Intraradicular smear removal efficacy of triphala as a final rinse solution in curved canals: a scanning electron microscope study[J]. J Pharm Bioallied Sci, 2019, 11(): S420-S428.
[1] 蒋丽,何飞. 再生性牙髓治疗在成熟恒牙中应用的临床研究进展[J]. 国际口腔医学杂志, 2025, 52(4): 449-455.
[2] 董尚兰,冷沙,郑庆华,张岚,黄定明. 金属基纳米粒子在控制根管感染中的应用[J]. 国际口腔医学杂志, 2024, 51(6): 785-792.
[3] 纪寅飞, 张岚, 黄定明. 微创髓腔通路对根管治疗过程的影响[J]. 国际口腔医学杂志, 2024, 51(5): 558-564.
[4] 高宇天,苏勤. 酸性氧化电位水在根管治疗中的研究与应用[J]. 国际口腔医学杂志, 2023, 50(4): 401-406.
[5] 汪牡丹,宋东哲,黄定明. 开髓洞型对患牙根管治疗术后抗折性能影响的研究进展[J]. 国际口腔医学杂志, 2023, 50(2): 186-194.
[6] 王璐璇,侯本祥. 根管内氢氧化钙残留对根管治疗的影响[J]. 国际口腔医学杂志, 2022, 49(3): 367-372.
[7] 戢晓,景钫淇,李雅,薛晶. 根管预备顺序的数据模拟优化研究[J]. 国际口腔医学杂志, 2022, 49(1): 37-47.
[8] 何蓉,刘学军,周宇琨. 光子引导的光声流效应在根管荡洗中应用的系统评价[J]. 国际口腔医学杂志, 2021, 48(6): 644-655.
[9] 邢桂琪,郭林溪,苏勤. 根管治疗后疾病的综合评估和治疗决策[J]. 国际口腔医学杂志, 2021, 48(5): 579-584.
[10] 彭玮琪,高原,徐欣. 髓腔通路设计的微创理念及其研究进展[J]. 国际口腔医学杂志, 2021, 48(4): 433-438.
[11] 李米雪子,张琛. 椅旁计算机辅助设计/计算机辅助制作髓腔固位冠修复根管治疗后磨牙的临床考量[J]. 国际口腔医学杂志, 2021, 48(3): 274-279.
[12] 谭凯璇,李帆,张利娟,李姗姗,卢洁,张颖,杨芳. 根管再治疗并发皮下气肿1例[J]. 国际口腔医学杂志, 2020, 47(5): 563-566.
[13] 唐蓓,赵文俊,王虎,郑广宁,游梦. 根管超填导致下牙槽神经损伤2例[J]. 国际口腔医学杂志, 2020, 47(3): 293-296.
[14] 许庆安,樊明文. 非器械根管治疗与多声波超洁净系统[J]. 国际口腔医学杂志, 2019, 46(5): 522-525.
[15] 黄丽东, 宫玮玉, 董艳梅. 根管冲洗的研究进展[J]. 国际口腔医学杂志, 2018, 45(4): 465-472.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 王昆润. 二甲亚砜和双氯芬酸并用治疗根尖周炎[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 宋红. 青少年牙周炎外周血分叶核粒细胞的趋化功能[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 高卫民,李幸红. 发达国家牙医学院口腔种植学教学现状[J]. 国际口腔医学杂志, 1999, 26(06): .
[4] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[5] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 逄键梁. 两例外胚层发育不良儿童骨内植入种植体后牙槽骨生长情况[J]. 国际口腔医学杂志, 1999, 26(05): .
[7] 王昆润. 后牙冠根斜形牙折的治疗[J]. 国际口腔医学杂志, 1999, 26(05): .
[8] 温秀杰. 氟化物对牙本质脱矿抑制作用的体外实验研究[J]. 国际口腔医学杂志, 1999, 26(05): .
[9] 轩东英. 不同赋形剂对氢氧化钙抗菌效果的影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[10] 房兵. 唇腭裂新生儿前颌骨矫正方法及对上颌骨生长发育的影响[J]. 国际口腔医学杂志, 1999, 26(05): .