国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (4): 414-418.doi: 10.7518/gjkq.2023047
Sun Xiaoqian1,2(),Zhang Jun1,2(
)
摘要:
随着肿瘤细胞外基质力学特性逐步被认识,在二维和三维培养条件下考察机械力环境影响肿瘤生物学行为的研究也越来越多。机体的细胞外基质中存在各种机械力,这些力学信号可以转化为生化信号,改变组织细胞微环境并影响其代谢,从而驱动肿瘤发展。本文就拉伸力、压应力和流体剪切力这3种常见机械力对头颈癌细胞增殖、侵袭、迁移等生物学行为的影响及其相关机制进行文献回顾和综述,为进一步探讨机械力环境在头颈癌中发挥的作用提供依据。
中图分类号:
1 | Gupta B, Johnson NW, Kumar N. Global epidemio-logy of head and neck cancers: a continuing cha-llenge[J]. Oncology, 2016, 91(1): 13-23. |
2 | Chow LQM. Head and neck cancer[J]. N Engl J Med, 2020, 382(1): 60-72. |
3 | Winkler J, Abisoye-Ogunniyan A, Metcalf KJ, et al. Concepts of extracellular matrix remodelling in tumour progression and metastasis[J]. Nat Commun, 2020, 11(1): 5120. |
4 | Huang GY, Xu F, Genin GM, et al. Mechanical microenvironments of living cells: a critical frontier in mechanobiology[J]. Acta Mech Sin, 2019, 35(2): 265-269. |
5 | Zhang WW, Huang GY, Xu F. Engineering biomaterials and approaches for mechanical stretching of cells in three dimensions[J]. Front Bioeng Biotechnol, 2020, 8: 589590. |
6 | Levayer R. Solid stress, competition for space and cancer: the opposing roles of mechanical cell competition in tumour initiation and growth[J]. Semin Cancer Biol, 2020, 63: 69-80. |
7 | Riehl BD, Park JH, Kwon IK, et al. Mechanical stretching for tissue engineering: two-dimensional and three-dimensional constructs[J]. Tissue Eng Part B Rev, 2012, 18(4): 288-300. |
8 | Kamble H, Vadivelu R, Barton M, et al. An electromagnetically actuated double-sided cell-stretching device for mechanobiology research[J]. Micromachines (Basel), 2017, 8(8): 256. |
9 | Monemian Esfahani A, Rosenbohm J, Reddy K, et al. Tissue regeneration from mechanical stretching of cell-cell adhesion[J]. Tissue Eng Part C Methods, 2019, 25(11): 631-640. |
10 | Gong FY, Yang YC, Wen LT, et al. An overview of the role of mechanical stretching in the progression of lung cancer[J]. Front Cell Dev Biol, 2021, 9: 781828. |
11 | 何海波, 唐休发, 李龙江, 等. 力学刺激对人腺样囊性癌高低转移细胞系增殖的影响[J]. 实用口腔医学杂志, 2007, 23(1): 87-90. |
He HB, Tang XF, Li LJ, et al. The effect of mechanical stimulation on the proliferation of adenoid cystic carcinoma cell lines[J]. J Pract Somatol, 2007, 23(1): 87-90. | |
12 | 何海波, 唐休发, 李龙江, 等. 力学刺激对人腺样囊性癌高低转移细胞株中E-cad/cat复合体的影响[J]. 华西口腔医学杂志, 2007, 25(1): 29-32. |
He HB, Tang XF, Li LJ, et al. Effect of mechanical stimulation on the expression of e-cadherin/caten-inin complex in salivary adenoid cystic carcinoma[J]. West China J Stomatol, 2007, 25(1): 29-32. | |
13 | 谢永芳, 贾增强, 王国辉, 等. 拉伸刺激对人舌鳞癌Tca8113细胞增殖的影响[J]. 太原理工大学学报, 2010, 41(2): 131-133. |
Xie YF, Jia ZQ, Wang GH, et al. Effects of stretch on proliferation of human squamous carcinoma of tongue cell line Tca8113[J]. J Taiyuan Univ Technol, 2010, 41(2): 131-133. | |
14 | 孙明星, 薛晓凤, 任富凯, 等. 拉伸刺激对舌鳞癌细胞侵袭力及MMP-2表达的影响[J]. 口腔颌面外科杂志, 2012, 22(1): 27-29. |
Sun MX, Xue XF, Ren FK, et al. Effect of tensile stimulation on expression of MMP-2 and the invasion capacity in human tongue squamous cell carcinoma[J]. J Oral Maxillofac Surg, 2012, 22(1): 27-29. | |
15 | Yadav S, Vadivelu R, Ahmed M, et al. Stretching cells-an approach for early cancer diagnosis[J]. Exp Cell Res, 2019, 378(2): 191-197. |
16 | Runge J, Reichert TE, Fritsch A, et al. Evaluation of single-cell biomechanics as potential marker for oral squamous cell carcinomas: A pilot study[J]. Oral Dis, 2014, 20(3): e120-e127. |
17 | Cheng S, Gandevia SC, Green M, et al. Viscoelastic properties of the tongue and soft palate using MR elastography[J]. J Biomech, 2011, 44(3): 450-454. |
18 | Brown EC, Cheng S, McKenzie DK, et al. Tongue stiffness is lower in patients with obstructive sleep apnea during wakefulness compared with matched control subjects[J]. Sleep, 2015, 38(4): 537-544. |
19 | Matte BF, Kumar A, Placone JK, et al. Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma[J]. J Cell Sci, 2019, 132(1): jcs224360. |
20 | Barbosa MAG, Xavier CPR, Pereira RF, et al. 3D cell culture models as recapitulators of the tumor microenvironment for the screening of anti-cancer drugs[J]. Cancers (Basel), 2021, 14(1): 190. |
21 | Smith A, Teknos TN, Pan Q. Epithelial to mesenchymal transition in head and neck squamous cell carcinoma[J]. Oral Oncol, 2013, 49(4): 287-292. |
22 | Broders-Bondon F, Nguyen Ho-Bouldoires TH, Fernandez-Sanchez ME, et al. Mechanotransduction in tumor progression: the dark side of the force[J]. J Cell Biol, 2018, 217(5): 1571-1587. |
23 | Johnson DE, Burtness B, Leemans CR, et al. Head and neck squamous cell carcinoma[J]. Nat Rev Dis Primers, 2020, 6(1): 92. |
24 | Shigeishi H, Yokoyama S, Murodumi H, et al. Effect of hydrogel stiffness on morphology and gene expression pattern of CD44high oral squamous cell carcinoma cells[J]. Int J Clin Exp Pathol, 2019, 12(8): 2826-2836. |
25 | Hui L, Zhang JR, Ding XX, et al. Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells[J]. Int J Oncol, 2017, 50(4): 1439-1447. |
26 | Morikura T, Miyata S. Effect of mechanical compression on invasion process of malignant melanoma using in vitro three-dimensional cell culture device[J]. Micromachines (Basel), 2019, 10(10): 666. |
27 | Koumoutsakos P, Pivkin I, Milde F. The fluid mechanics of cancer and its therapy[J]. Annu Rev Fluid Mech, 2013, 45(1): 325-355. |
28 | Fennewald SM, Kantara C, Sastry SK, et al. Laminin interactions with head and neck cancer cells under low fluid shear conditions lead to integrin activation and binding[J]. J Biol Chem, 2012, 287(25): 21058-21066. |
29 | Patergnani S, Danese A, Bouhamida E, et al. Various aspects of calcium signaling in the regulation of apoptosis, autophagy, cell proliferation, and cancer[J]. Int J Mol Sci, 2020, 21(21): 8323. |
30 | Bruce JIE, James AD. Targeting the calcium signalling machinery in cancer[J]. Cancers (Basel), 2020, 12(9): 2351. |
31 | Canales Coutiño B, Mayor R. Mechanosensitive ion channels in cell migration[J]. Cells Dev, 2021, 166: 203683. |
32 | Lien SC, Chang SF, Lee PL, et al. Mechanical regulation of cancer cell apoptosis and autophagy: roles of bone morphogenetic protein receptor, Smad1/5, and p38 MAPK[J]. Biochim Biophys Acta, 2013, 1833(12): 3124-3133. |
33 | Chang SF, Chang CA, Lee DY, et al. Tumor cell cycle arrest induced by shear stress: roles of integrins and Smad[J]. Proc Natl Acad Sci U S A, 2008, 105(10): 3927-3932. |
34 | Liu SF, Zhou FT, Shen Y, et al. Fluid shear stress induces epithelial-mesenchymal transition (EMT) in Hep-2 cells[J]. Oncotarget, 2016, 7(22): 32876-32892. |
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