国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (4): 414-418.doi: 10.7518/gjkq.2023047

• 口腔肿瘤学专栏 • 上一篇    下一篇

机械力环境影响头颈癌生物学行为及作用机制的研究进展

孙晓倩1,2(),张军1,2()   

  1. 1.天津市口腔医院口腔颌面外科 南开大学医学院 天津 300041
    2.天津市口腔功能重建重点实验室 天津 300041
  • 收稿日期:2022-12-05 修回日期:2023-04-03 出版日期:2023-07-01 发布日期:2023-06-21
  • 通讯作者: 张军
  • 作者简介:孙晓倩，硕士，Email：<email>714692243@qq.com</email>
  • 基金资助:
    天津市临床医学重点学科专项基金(TJYXZDXK-048A)

Advances in the effects of mechanical environment on the biological behaviors and mechanism of head and neck cancer

Sun Xiaoqian1,2(),Zhang Jun1,2()   

  1. 1.Dept. of Oral and Maxillofacial Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041, China
    2.Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China
  • Received:2022-12-05 Revised:2023-04-03 Online:2023-07-01 Published:2023-06-21
  • Contact: Jun Zhang
  • Supported by:
    Tianjin Clinical Medicine Key Discipline Special Fund(TJYXZDXK-048A)

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摘要：

随着肿瘤细胞外基质力学特性逐步被认识，在二维和三维培养条件下考察机械力环境影响肿瘤生物学行为的研究也越来越多。机体的细胞外基质中存在各种机械力，这些力学信号可以转化为生化信号，改变组织细胞微环境并影响其代谢，从而驱动肿瘤发展。本文就拉伸力、压应力和流体剪切力这3种常见机械力对头颈癌细胞增殖、侵袭、迁移等生物学行为的影响及其相关机制进行文献回顾和综述，为进一步探讨机械力环境在头颈癌中发挥的作用提供依据。

关键词: 头颈癌, 拉伸力, 压应力, 流体剪切力, 生物学行为

Abstract:

With the gradual understanding of the mechanical properties of tumor extracellular matrix, research that focuses on tumor biological behavior by examining the mechanical environment in two- and three-dimensional culture conditions is also increasing. There are various mechanical stimulations in the extracellular matrix of the body. These mecha-nical signals can be converted into biochemical signals, changing the microenvironment of tissue cells and affecting their metabolism to drive the development of tumors. Therefore, in this paper, we review the effects of three common mechanical forces, including tension, compression, and fluid shear stress, on the biological behaviors of proliferation, migration, and invasion in head and neck cancer and related mechanisms. The aim is to gain a better understanding of the key role of mechanical environment in head and neck cancer.

Key words: head and neck cancer, tension, compression, fluid shear stress, biological behavior

中图分类号: 

  • R 739.8
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