国际口腔医学杂志

国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (2): 235-243.doi: 10.7518/gjkq.2020013

• 综述 • 上一篇    下一篇

浓缩生长因子在口腔临床中的应用及研究进展

魏中武1,黄谢山1(),陈灼庚2   

  1. 1. 中南大学湘雅医学院附属海口医院口腔颌面外科 海口 570208
    2. 中南大学湘雅医学院附属海口医院口腔种植科 海口 570208
  • 收稿日期:2019-05-14 修回日期:2019-09-29 出版日期:2020-03-01 发布日期:2020-03-12
  • 通讯作者: 黄谢山
  • 作者简介:魏中武,医师,硕士,Email： 359322794@qq.com
  • 基金资助:
    海南省自然科学基金面上项目(818MS138)

Application and research progress on concentrated growth factor in oral clinic

Wei Zhongwu1,Huang Xieshan1(),Chen Zhuogeng2   

  1. 1. Dept. of Oral and Maxillofacial Surgery, Haikou Hospital Affiliated to Xiangya Medical School, Central South University, Haikou 570208, China
    2. Dept. of Dental Implantology, Haikou Hospital Affiliated to Xiangya Medical School, Central South University, Haikou 570208, China
  • Received:2019-05-14 Revised:2019-09-29 Online:2020-03-01 Published:2020-03-12
  • Contact: Xieshan Huang
  • Supported by:
    This study was supported by Surface Project of Hainan Natural Science Foundation(818MS138)

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摘要：

浓缩生长因子（CGF）是通过差速离心血液样品制备的最新一代血小板浓缩制品,与前两代血小板浓缩制品相比,相同体积中含有更丰富的生长因子,纤维蛋白基质的拉伸强度和黏度更高,体内作用时间更长,拥有更为优秀的组织再生能力。因CGF由自体血液离心制得,取材方便,制备简单、高效,内含大量发挥骨诱导作用的生长因子和发挥骨引导作用的纤维蛋白基质,可激活血管新生,能有效诱导和加速软组织和骨组织的再生,缩短愈合时间,无交叉感染和免疫排斥风险,并具有一定的抗炎作用,已在口腔种植及颌面外科等领域广泛应用。本文就CGF在口腔临床中的应用及相关研究进展进行最新的综述,望为CGF在口腔临床中的进一步应用提供一定的理论依据。

关键词: 浓缩生长因子, 口腔临床, 研究进展

Abstract:

Concentrated growth factor (CGF) is a new generation of platelet concentrate prepared by differential centrifugation. Compared with the two previous generations of platelet concentrates, CGF contains more growth factors in the same volume. It has a fibrin matrix with high tensile strength and viscosity and long application time in the body and exhibits good tissue regeneration ability. CGF has been widely used in oral implant and maxillofacial surgery because of its simple and efficient preparation by autologous blood. Moreover, CGF contains a large number of growth factors that exert an osteoinductive effect and a fibrin matrix that plays a role in bone guidance. Furthermore, CGF can activate angiogenesis and effectively induce and accelerate soft and bone tissue. CGF can also shorten the healing time without the risk of cross-infection and immune rejection and has a certain anti-inflammatory effect. This article reviews the application of CGF in oral cavity and related research progress. We hope to provide a theoretical basis for the further application of CGF in oral clinics.

Key words: concentrated growth factor, oral clinical, research progress

中图分类号: 

  • Q26
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