Int J Stomatol

Inter J Stomatol ›› 2017, Vol. 44 ›› Issue (1): 103-107.doi: 10.7518/gjkq.2017.01.021

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Saccharomyces albicans: its dental caries correlation and mechanism

Liu Shiyu, He Jinzhi, Li Mingyun.   

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2016-03-19 Online:2017-01-01 Published:2017-01-01

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Abstract: Saccharomyces albicans(S. albicans) is a Gram-positive fungus and widely exists in the upper respiratory tract, intestinal canal, and vagina of healthy people. S. albicans does not cause diseases in a state of symbiosis with the host. The ability of S. albicans to switch its morphotype from yeast to hyphal forms contributes to its pathogenesis and leads to oral mucosa infection and dental caries. In oral biofilms of caries-affected people, an interaction may exist between S. albicans and Streptococcus mutans(S. mutans) leading to the development of dental caries. S. albicans tends to adhere tightly to Streptococcus gordonii(S. gordonii), that is, a polysaccharide existing on the surface of the cell wall of S. gordonii is one of the adhesion receptors of S. albicans. S. gordonii can alleviate the inhibition effect of quorum-sensing mechanism on hyphae formation and biofilm development of S. albicans, thereby increasing the biomass. This review focused on S. albicans, the correlation of S. albicansand dental caries, and the research progress on the possible specific mechanism involved in the occurrence and development of dental caries caused by the interactions of S. albicans, together with S. mutans, S. gordonii, and other oral bacteria. This study aims to provide ideas and references for future clinical research.

Key words: Saccharomyces albicans, dental ceries, Streptococcus mutans, Streptococcus gordonii

CLC Number: 

  • R780.2

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