国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (5): 579-583.doi: 10.7518/gjkq.2018.05.014

• 综述 • 上一篇    下一篇

糖尿病对唾液分泌和唾液腺的影响及其机制

李维,农晓琳()   

  1. 广西医科大学口腔医学院·附属口腔医院口腔颌面外科 南宁 530021
  • 收稿日期:2017-10-22 修回日期:2018-04-30 出版日期:2018-09-01 发布日期:2018-09-20
  • 通讯作者: 农晓琳
  • 作者简介:李维,硕士,Email:398843789@qq.com
  • 基金资助:
    广西科学研究与技术开发计划项目(桂科能14123006-2);广西医疗卫生适宜技术开发与推广应用项目(S201688);广西高等教育本科教学改革工程立项项目(2016JGA161-2);广西研究生教育创新计划项目(201010598RY10)

Effect and mechanism of diabetes on saliva secretion and salivary glands

Wei Li,Xiaolin. Nong()   

  1. Dept. of Oral and Maxillofacial Surgery, College and Hospital of Stomatology, Guangxi Medical University, Nanning 530021, China
  • Received:2017-10-22 Revised:2018-04-30 Online:2018-09-01 Published:2018-09-20
  • Contact: Xiaolin. Nong
  • Supported by:
    This study was supported by Scientific Research and Technology Development Project of Guangxi(桂科能14123006-2);Guangxi medical and health appropriate technology development and popularization and application project(S201688);Guangxi higher education undergraduate teaching reform project(2016JGA161-2);Innovation Project of Guangxi Graduate Education(201010598RY10)

摘要:

糖尿病及其并发症能够极大地降低患者的生活质量,口渴多饮是糖尿病患者主要典型症状之一,唾液腺改变及唾液分泌减少是糖尿病患者口渴多饮的重要原因,也是糖尿病患者诸多口腔问题的危险因素之一。研究糖尿病对唾液分泌及唾液腺的影响机制将对预防改善糖尿病患者口渴多饮症状,保持口腔健康,提高生活质量有重要意义。本文就糖尿病对唾液分泌和唾液腺的影响及其机制研究进展作一综述。

关键词: 糖尿病, 唾液腺, 唾液, 唾液减少, 口干症

Abstract:

Diabetes and its complications can greatly reduce the quality of life of patients, dry mouth and more water intake is one of the main symptoms of diabetes. Saliva decrements and salivary glands changes may be important causes of diabetic patients to drink more, but also one of the risk factors for other oral problems. Studying the effection mechanism of diabetes on salivary secretion and salivary glands will be important for preventing and curing patients’ symptoms of thirst, maintaining oral health and improving their quality of life. This article reviews the effect of diabetes on saliva secretion and salivary glands and its mechanism.

Key words: diabetes, salivary glands, saliva, saliva reduction, dry mouth

中图分类号: 

  • R780.1
[1] International Diabetes Federation. IDF diabetes atlas-7th Edition[EB/OL]. ,[ 2015-12-01].
[2] Löe H , Periodontal disease. The sixth complication of diabetes mellitus[J]. Diabetes Care, 1993,16(1):329-334.
doi: 10.2337/diacare.16.1.329 pmid: 8422804
[3] Negrato CA, Tarzia O , Buccal alterations in diabetes mellitus[J]. Diabetol Metab Syndr, 2010,2:3.
doi: 10.1186/1758-5996-2-3 pmid: 20180965
[4] Takeuchi K, Furuta M, Takeshita T , et al. Risk factors for reduced salivary flow rate in a Japanese popula-tion: the Hisayama Study[J]. Biomed Res Int, 2015,2015:381821.
doi: 10.1155/2015/381821 pmid: 4332456
[5] Pedersen AM, Bardow A, Jensen SB , et al. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion[J]. Oral Dis, 2002,8(3):117-129.
doi: 10.1034/j.1601-0825.2002.02851.x pmid: 12108756
[6] López-Pintor RM, Casañas E, González-Serrano J , et al. Xerostomia, hyposalivation, and salivary flow in diabetes patients[J]. J Diabetes Res, 2016,2016:4372852.
doi: 10.1155/2016/4372852
[7] Lima DLF, Carneiro SDRM, Barbosa FTS , et al. Salivary flow and xerostomia in older patients with type 2 diabetes mellitus[J]. PLoS One, 2017,12(8):e0180891.
doi: 10.1371/journal.pone.0180891 pmid: 5540406
[8] Kamata M, Shirakawa M, Kikuchi K , et al. Histo-logical analysis of the sublingual gland in rats with streptozotocin-induced diabetes[J]. Okajimas Folia Anat Jpn, 2007,84(2):71-76.
doi: 10.2535/ofaj.84.71 pmid: 17969996
[9] 李维善, 孙庆顺 . 实验性糖尿病大鼠颌下腺超微结构观察[J]. 临床口腔医学杂志, 2006,22(3):147-149.
doi: 10.3969/j.issn.1003-1634.2006.03.007
Li WS, Sun QS . The ultrastructure study on the submandibular glands in experimental diabetes rats[J]. J Clin Stomatol, 2006,22(3):147-149.
doi: 10.3969/j.issn.1003-1634.2006.03.007
[10] Agre P , Aquaporin water channels (Nobel Lecture)[J]. Angew Chem Int Ed Engl, 2004,43(33):4278-4290.
doi: 10.1002/chin.200445287
[11] Verkman AS , Novel roles of aquaporins revealed by phenotype analysis of knockout mice[J]. Rev Physiol Biochem Pharmacol, 2005,155:31-55.
doi: 10.1007/3-540-28217-3
[12] Delporte C , Aquaporins in salivary glands and pan-creas[J]. Biochim Biophys Acta, 2014,1840(5):1524-1532.
doi: 10.1016/j.bbagen.2013.08.007 pmid: 23954206
[13] Ishikawa Y, Cho G, Yuan Z , et al. Aquaporin-5 water channel in lipid rafts of rat parotid glands[J]. Biochim Biophys Acta, 2006,1758(8):1053-1060.
doi: 10.1016/j.bbamem.2006.03.026 pmid: 16712780
[14] Ishikawa Y, Inoue N, Zhenfang Y , et al. Molecular mechanisms and drug development in aquaporin wa- ter channel diseases: the translocation of aquaporin-5 from lipid rafts to the apical plasma membranes of parotid glands of normal rats and the impairment of it in diabetic or aged rats[J]. J Pharmacol Sci, 2004,96(3):271-275.
doi: 10.1254/jphs.FMJ04004X6
[15] Bhattarai KR, Lee SW, Kim SH , et al. Ixeris dentata extract regulates salivary secretion through the acti-vation of aquaporin-5 and prevents diabetes-induced xerostomia[J]. J Exp Pharmacol, 2017,9:81-91.
doi: 10.2147/JEP
[16] Mednieks MI, Szczepanski A, Clark B , et al. Protein expression in salivary glands of rats with streptozo-tocin diabetes[J]. Int J Exp Pathol, 2009,90(4):412-422.
doi: 10.1111/j.1365-2613.2009.00662.x pmid: 19659899
[17] 王云飞, 钱品品, 王勇帅 , 等. 唾液淀粉酶活性与肥胖关系初探[J]. 山东师范大学学报(自然科学版), 2017,32(2):121-124.
doi: 10.3969/j.issn.1001-4748.2017.02.020
Wang YF, Qian PP, Wang YS , et al. The preliminary study on the relationship between salivary alpha-amylase activity and obesity[J]. J Shandong Normal Univers (Nat Sci), 2017,32(2):121-124.
doi: 10.3969/j.issn.1001-4748.2017.02.020
[18] Kaufman E, Lamster IB , Analysis of saliva for perio-dontal diagnosis—a review[J]. J Clin Periodontol, 2000,27(7):453-465.
doi: 10.1034/j.1600-051x.2000.027007453.x pmid: 10914885
[19] Numabe Y, Hisano A, Kamoi K , et al. Analysis of saliva for periodontal diagnosis and monitoring[J]. Dent Japan, 2004,40:115-119.
[20] Defagó MD, Valentich MA, Actis AB , Lipid charac-terization of human saliva[J]. J Calif Dent Assoc, 2011,39(12):874-880.
[21] Kensche A, Reich M, Kümmerer K , et al. Lipids in preventive dentistry[J]. Clin Oral Investig, 2013,17(3):669-685.
doi: 10.1007/s00784-012-0835-9
[22] Hand AR, Weiss RE , Effects of streptozotocin-induced diabetes on the rat parotid gland[J]. Lab Invest, 1984,51(4):429-440.
doi: 10.1016/S0015-7368(84)72350-4 pmid: 6482385
[23] Łukaszuk B, Kurek K, Mikłosz A , et al. The role of PGC-1α in the development of insulin resistance in skeletal muscle-revisited[J]. Cell Physiol Biochem, 2015,37(6):2288-2296.
doi: 10.1159/000438584
[24] Bonen A, Tandon NN, Glatz JF , et al. The fatty acid transporter FAT/CD36 is upregulated in subcuta-neous and visceral adipose tissues in human obesity and type 2 diabetes[J]. Int J Obes (Lond), 2006,30(6):877-883.
doi: 10.1038/sj.ijo.0803212
[25] Matczuk J, Zalewska A, Łukaszuk B , et al. Insulin resistance and obesity affect lipid profile in the salivary glands[J]. J Diabetes Res, 2016,2016:8163474.
doi: 10.1155/2016/8163474
[26] Matczuk J, Zalewska A, Łukaszuk B , et al. Effect of streptozotocin-induced diabetes on lipids metabolism in the salivary glands[J]. Prostaglandins Other Lipid Mediat, 2016,126:9-15.
doi: 10.1016/j.prostaglandins.2016.08.003 pmid: 27640168
[27] Garbowska M, Łukaszuk B, Mikłosz A , et al. Sphin-golipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes[J]. J Cell Physiol, 2017,232(10):2766-2775.
doi: 10.1002/jcp.v232.10
[28] Katona K, Elekes E, Farkas N , et al. Image analysis of fatty infiltration in labial salivary gland biopsies: extent and its correlation to age, obesity and diabetes[J]. J Oral Pathol Med, 2017,46(7):537-542.
doi: 10.1111/jop.2017.46.issue-7
[29] Nogueira FN, Carvalho AM, Yamaguti PM , et al. Antioxidant parameters and lipid peroxidation in salivary glands of streptozotocin-induced diabetic rats[J]. Clin Chim Acta, 2005,353(1/2):133-139.
doi: 10.1016/j.cccn.2004.11.004
[30] Deconte SR, Oliveira RJ, Calábria LK , et al. Altera-tions of antioxidant biomarkers and type Ⅰ collagen deposition in the parotid gland of streptozotocin-in-duced diabetic rats[J]. Arch Oral Biol, 2011,56(8):744-751.
doi: 10.1016/j.archoralbio.2011.01.005
[31] Zalewska A, Knaś M, Maciejczyk M , et al. Antioxi-dant profile, carbonyl and lipid oxidation markers in the parotid and submandibular glands of rats in different periods of streptozotocin induced diabetes[J]. Arch Oral Biol, 2015,60(9):1375-1386.
doi: 10.1016/j.archoralbio.2015.06.012
[32] Knaś M, Maciejczyk M, Daniszewska I , et al. Oxida-tive damage to the salivary glands of rats with strep-tozotocin-induced diabetes-temporal study: oxidative stress and diabetic salivary glands[J]. J Diabetes Res, 2016,2016:4583742.
[33] Aljerf L, Alhaffar I , Salivary distinctiveness and modifications in males with diabetes and Behçet’s disease[J]. Biochem Res Int, 2017,2017:9596202.
doi: 10.1155/2017/9596202 pmid: 1
[34] Aitken JP, Ortiz C, Morales-Bozo I , et al. α-2-macro-globulin in saliva is associated with glycemic control in patients with type 2 diabetes mellitus[J]. Dis Markers, 2015,2015:128653.
[35] Satish BN, Srikala P, Maharudrappa B , et al. Saliva: a tool in assessing glucose levels in diabetes mellitus[J]. J Int Oral Health, 2014,6(2):114-117.
pmid: 24876711
[1] 杨静,柳登高. 内镜下激光碎石术治疗唾液腺结石病的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 704-710.
[2] 赵玲帆, 周杨, 叶鑫鑫, 张强. 肾移植术后腮腺低分化黏液表皮样癌1例[J]. 国际口腔医学杂志, 2023, 50(4): 419-422.
[3] 杨倩娟,宋致馨,方世殊,顾泽旭,金作林,刘倩. 基于唾液代谢组学的口腔疾病研究新进展[J]. 国际口腔医学杂志, 2023, 50(3): 321-328.
[4] 陈小利,张帆,刘程程. 光生物调节在放射治疗后口腔并发症防治中的应用进展[J]. 国际口腔医学杂志, 2022, 49(6): 707-716.
[5] 叶玉琳,江莉婷,高益鸣. 舍格伦综合征唾液腺中自噬现象的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 556-560.
[6] 余舒星,邹静,李雨庆. 基于唾液检测病毒感染性生物标志物的研究进展[J]. 国际口腔医学杂志, 2022, 49(2): 189-196.
[7] 朱锦怡,樊琪,周媛,邹静,黄睿洁. 唾液蛋白作为低龄儿童龋预测标志物的研究进展[J]. 国际口腔医学杂志, 2022, 49(2): 212-219.
[8] 范宇,程磊. 吸烟影响口腔微环境及其在龋病进展中的作用[J]. 国际口腔医学杂志, 2021, 48(5): 609-613.
[9] 马平川,李春洁,李龙江. 唾液腺导管癌的诊疗研究进展[J]. 国际口腔医学杂志, 2021, 48(4): 459-467.
[10] 易祖木,王昕宇,伍颖颖. 糖尿病患者口腔细菌多样性的变化[J]. 国际口腔医学杂志, 2020, 47(5): 522-529.
[11] 杨虹,晋瑜,赖文莉. 安慰剂调节正畸牙移动疼痛的随机交叉对照试验[J]. 国际口腔医学杂志, 2020, 47(4): 424-430.
[12] 黄璐,戴杰,吴燕岷. 唾液生物标志物在口腔癌筛查中的应用[J]. 国际口腔医学杂志, 2020, 47(1): 68-75.
[13] 陈东,杨征,蒋丽. 放射性口腔干燥症的评估与临床管理的研究进展[J]. 国际口腔医学杂志, 2019, 46(6): 711-717.
[14] 孟璐璐,杜晓红,武云霞. 灼口综合征唾液因素的研究进展[J]. 国际口腔医学杂志, 2019, 46(4): 463-468.
[15] 赵鹏飞,王琪. 伴糖尿病患者种植骨缺损的病因及治疗的研究进展[J]. 国际口腔医学杂志, 2019, 46(2): 244-248.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 王昆润. 二甲亚砜和双氯芬酸并用治疗根尖周炎[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 汤庆奋,王学侠. 17β-雌二醇对人类阴道和口腔颊粘膜的渗透性[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 潘劲松. 颈总动脉指压和颈内动脉球囊阻断试验在大脑血液动力学中的不同影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 王昆润. 后牙冠根斜形牙折的治疗[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 杨锦波. 嵌合体防龋疫苗的研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 王昆润. 下颔骨成形术用网状钛板固定植骨块[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 汪月月,郭莉莉. 口腔机能与老化—痴呆危险因素流行病学研究[J]. 国际口腔医学杂志, 1999, 26(04): .
[8] 丁刚. 应用硬组织代用品种植体行丰颏术[J]. 国际口腔医学杂志, 1999, 26(04): .
[9] 田磊. 局部应用脂多糖后结合上皮反应性增生的变化[J]. 国际口腔医学杂志, 1999, 26(04): .
[10] 戴青. 口腔念珠菌病的新分类[J]. 国际口腔医学杂志, 1999, 26(04): .