国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (3): 320-325.doi: 10.7518/gjkq.2019030

• 综述 • 上一篇    下一篇

特异性AT序列结合蛋白2在颌面部发育及牙周组织再生中作用的研究进展

贾婷婷,颜世果()   

  1. 山东大学口腔医院牙周科,山东省口腔组织再生重点实验室 济南 250012
  • 收稿日期:2018-10-19 修回日期:2019-01-03 出版日期:2019-05-01 发布日期:2019-06-05
  • 通讯作者: 颜世果 E-mail:syan@sdu.edu.cn
  • 作者简介:贾婷婷,硕士,Email:jtt0530@126.com
  • 基金资助:
    国家自然科学基金(81200790);山东重点研究开发计划(公益类)(2017GSF218063);山东省自然科学基金(ZR2012HQ028)

Research progress on the role of special AT-rich sequence binding protein 2 in maxillofacial development and perio-dontal regeneration

Tingting Jia,Shiguo Yan()   

  1. Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China
  • Received:2018-10-19 Revised:2019-01-03 Online:2019-05-01 Published:2019-06-05
  • Contact: Shiguo Yan E-mail:syan@sdu.edu.cn
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81200790);Key Research and Development Plan (Public Welfare Category) of Shandong(2017GSF218063);Natural Science Foundation of Shandong Province(ZR2012HQ028)

摘要:

特异性AT序列结合蛋白(SATB)2是一种组织特异性表达的核基质序列结合蛋白。SATB2被鉴定为骨骼塑型和成骨细胞分化的分子决定因素,在颌面部发育中发挥关键作用,是有效的促进牙周再生的调控因子。本文就SATB2对颌面部发育的调控及其在牙周组织工程领域应用的研究现状进行综述。

关键词: 特异性AT序列结合蛋白2, 颌面部发育, 牙周组织再生

Abstract:

Special AT-rich sequence binding protein 2 (SATB2) is a tissue-specific nuclear matrix sequence binding protein. SATB2 has been identified as a molecular determinant of osteogenesis and osteoblast differentiation, plays a key role in maxillofacial development and is an effective regulator of periodontal regeneration. This article reviews the current status of regulation of maxillofacial development by SATB2 and its application in periodontal tissue engineering.

Key words: special AT-rich sequence binding protein 2, maxillofacial development, periodontal tissue regeneration

中图分类号: 

  • Q813
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