国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (5): 546-552.doi: 10.7518/gjkq.2018.05.009

• 综述 • 上一篇    下一篇

甘草及其提取物在防治口腔感染相关疾病中的应用

王静1,2,王艳2,王川东2,黄睿洁3,田燕4,胡玮2,邹静3()   

  1. 1. 山东中医药大学药学院 济南 250355
    2. 山东大学微生物技术国家重点实验室 济南 250100
    3. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院儿童口腔科 成都 610041
    4. 加州大学洛杉矶分校牙学院 洛杉矶 CA 90095
  • 收稿日期:2017-11-14 修回日期:2018-05-27 出版日期:2018-09-01 发布日期:2018-09-20
  • 通讯作者: 邹静 E-mail:zoujing1970@126.com
  • 作者简介:王静,博士,Email：wang01jing@126.com
  • 基金资助:
    国家自然科学基金(81470035);国家自然科学基金(31370110);国家自然科学基金(31570065);中国博士后科学基金(2016M592177)

Application of liquorice and its extract to the prevention and treatment of oral infections and associated diseases

Jing Wang1,2,Yan Wang2,Chuandong Wang2,Ruijie Huang3,Yan Tian4,Wei Hu2,Jing Zou3()   

  1. 1. College of Pharmaceutical Science, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    2. State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China
    3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    4. School of Dentistry, University of California, Los Angeles, Los Angeles CA 90095, USA
  • Received:2017-11-14 Revised:2018-05-27 Online:2018-09-01 Published:2018-09-20
  • Contact: Jing Zou E-mail:zoujing1970@126.com
  • Supported by:
    This study was supported by the National Natural Science Foundation of China(81470035);This study was supported by the National Natural Science Foundation of China(31370110);This study was supported by the National Natural Science Foundation of China(31570065);Postdoctoral Science Foundation of China(2016M592177)

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摘要：

作为使用时间最长且应用最广泛的中草药之一,甘草在现代医药学的研究和实践中对于多种疾病均显示明确疗效。其药理活性表现为抗炎、抗感染、抗溃疡及抗肿瘤等作用,主要存在于黄酮类、三萜皂苷类和多糖类化合物中。近年来的研究表明,甘草对于口腔感染相关的多种疾病具有良好的预防和治疗效果。本文综述了甘草及其特定提取物在防治龋病、牙周组织疾病、溃疡和念珠菌病等口腔疾病中的应用进展,并对相关制品用药安全性评价的情况进行介绍。

关键词: 甘草, 龋病, 变异链球菌, 牙周组织疾病, 白色假丝酵母, 复发性阿弗他溃疡

Abstract:

As one of the most ancient and widely used traditional Chinese herbal remedy, liquorice (root, rhizome and stolon of Glycyrrhiza species) shows definite curative effect on many diseases. Such effect has been further proved and confirmed by the research and practice of modern medicine and pharmacology. The major active components of liquorice are commonly identified as liquorice flavonoids, triterpene saponins and polysaccharides. These components are responsible for the phar-macological activities of this herbal remedy, e.g. anti-inflammation, anti-infection, anti-ulcer and antitumor effects. Licorice has numerous beneficial effects on oral infections and associated diseases, according to the results of previous studies. This paper reviews the application of liquorice and its extract to the prevention and treatment of dental caries, periodontitis, oral ulcers and candidiasis. Moreover, the medication safety of liquorice-related products is also discussed.

Key words: Glycyrrhiza, dental caries, Streptococcus mutans, periodontal disease, Candida albicans, recurrent aphthous ulcer

中图分类号: 

  • R781

图 1

甘草中部分活性化合物的结构"

表 1

甘草中对口腔感染相关疾病具有药理活性的化合物"

结构类别 活性化合物代表 治疗疾病 文献
紫檀烯类 甘草茎醇A 龋病 [6-7]
皂苷类 甘草甜素 龋病 [12]
口腔念珠菌病 [30]
甘草次酸 牙周组织病 [19]
口腔念珠菌病 [29]
芪类 甘草宁 龋病 [7]
牙周组织病 [33]
口腔念珠菌病 [30]
甘草西定 牙周组织病 [18]
甘草异黄烷A 牙周组织病 [18]
查耳酮类 甘草查尔酮A 口腔念珠菌病 [30]
类黄酮类 甘草素 口腔念珠菌病 [31]
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