国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (5): 522-526.doi: 10.7518/gjkq.2018.05.005

• 种植专栏 • 上一篇    下一篇

釉基质蛋白衍生物在口腔种植中的研究进展

米梦梦,夏海斌,王敏()   

  1. 武汉大学口腔医院种植科 武汉 430079
  • 收稿日期:2017-12-25 修回日期:2018-06-14 出版日期:2018-09-01 发布日期:2018-09-20
  • 通讯作者: 王敏
  • 作者简介:米梦梦,硕士,Email:mimeng1121@whu.edu.cn
  • 基金资助:
    国家自然科学基金(81500866)

Research progress on enamel matrix derivative in dental implantation

Mengmeng Mi,Haibin Xia,Min. Wang()   

  1. Dept. of Implantology, Hospital of Stomatology, Wuhan University, Wuhan 430079, China
  • Received:2017-12-25 Revised:2018-06-14 Online:2018-09-01 Published:2018-09-20
  • Contact: Min. Wang
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81500866)

摘要:

釉基质蛋白衍生物是从幼猪牙胚中提取的釉基质蛋白的衍生物,具有促进牙周组织再生、诱导骨组织形成和生物矿化等生物学特性。目前,由于釉基质蛋白衍生物能够促进牙骨质的再生、新生牙周膜纤维功能性排列和新牙槽骨形成,主要应用于牙周疾病的治疗。在口腔种植方面,釉基质蛋白衍生物具有促进骨-种植体界面的骨结合、种植体周骨缺损的修复和种植体周围软组织的愈合等作用,在口腔种植中的应用也越来越多,本文就釉基质蛋白衍生物在口腔种植中的应用作一综述。

关键词: 釉基质蛋白衍生物, 牙种植, 硬组织, 软组织

Abstract:

Enamel matrix derivative comes from enamel matrix proteins, which are extracted from young pig tooth germ. The derivative can promote regeneration of periodontal tissues, bone induction, and biomineralization. At present, enamel matrix derivative is mainly used to treat periodontal diseases by promoting regeneration of new cementum, insertion of new functionally oriented periodontal ligament fibers, and formation of new alveolar bone. When used in dental implantation, enamel matrix derivative can promote osseointegration of bone-implant interfaces, repair of bone defects in implants, and healing of soft tissue around implants. As dental implantation is applied in increasingly wider settings, this article offers an overview of the use of enamel matrix derivative in dental implantation.

Key words: enamel matrix derivative, dental implantation, hard tissue, soft tissue

中图分类号: 

  • R783.3
[1] Hammarström L, Heijl L, Gestrelius S , Periodontal regeneration in a buccal dehiscence model in mon-keys after application of enamel matrix proteins[J]. J Clin Periodontol, 1997,24(9 Pt 2):669-677.
doi: 10.1111/cpe.1997.24.issue-9
[2] 吴飞俊, 裴路 . 釉基质蛋白衍生物治疗牙周组织再生进展的研究[J]. 医学研究生学报, 2013,26(6):650-653.
Wu FJ, Pei L . Enamel matrix derivative and perio-dontal tissue regeneration[J]. J Med Postgra, 2013,26(6):650-653.
[3] Bartlett JD, Ganss B, Goldberg M , et al. Protein-protein interactions of the developing enamel matrix[J]. Curr Top Dev Biol, 2006,74:57-115.
doi: 10.1016/S0070-2153(06)74003-0
[4] Dacy JA, Spears R, Hallmon WW , et al. Effects of phosphated titanium and enamel matrix derivatives on osteoblast behavior in vitro[J]. Int J Oral Maxillo-fac Implants, 2007,22(5):701-709.
doi: 10.1016/j.ijom.2007.03.014 pmid: 3215085
[5] Miron RJ, Chandad F, Buser D , et al. Effect of enamel matrix derivative liquid on osteoblast and periodontal ligament cell proliferation and differentiation[J]. J Periodontol, 2016,87(1):91-99.
doi: 10.1902/jop.2015.150389
[6] Miron RJ, Sculean A, Cochran DL , et al. Twenty years of enamel matrix derivative: the past, the pre-sent and the future[J]. J Clin Periodontol, 2016,43(8):668-683.
doi: 10.1111/jcpe.12546 pmid: 26987551
[7] Qu Z, Andrukhov O, Laky M , et al. Effect of enamel matrix derivative on proliferation and differentiation of osteoblast cells grown on the titanium implant surface[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011,111(4):517-522.
doi: 10.1016/j.tripleo.2010.10.011
[8] Craig RG, Kamer AR, Kallur SP , et al. Effects of periodontal cell grafts and enamel matrix proteins on the implant-connective tissue interface: a pilot study in the minipig[J]. J Oral Implantol, 2006,32(5):228-236.
doi: 10.1563/820.1
[9] Wada Y, Mizuno M, Nodasaka Y , et al. The effect of enamel matrix derivative on spreading, prolifera-tion, and differentiation of osteoblasts cultured on zirconia[J]. Int J Oral Maxillofac Implants, 2012,27(4):849-858.
[10] 杨旭, 谭建国, 赵辛蓉 , 等. 釉基质蛋白促进骨质疏松症大鼠股骨种植体骨结合的研究[J]. 现代口腔医学杂志, 2006,20(5):505-508.
doi: 10.3969/j.issn.1003-7632.2006.05.020
Yang X, Tan JG, Zhao XR , et al. Effects of enamel matrix proteins on osseointegration of titanium im-plants in osteoporosis Wistar rats femurs[J]. J Modern Somatol, 2006,20(5):505-508.
doi: 10.3969/j.issn.1003-7632.2006.05.020
[11] Birang R, Shahabooei M, Mashhadiabbas F , et al. Effect of enamel matrix derivative on bone formation around intraosseous titanium implant: an experimen-tal study in canine model[J]. Dent Res J (Isfahan), 2012,9(6):790-796.
[12] Wen B, Li Z, Nie R , et al. Influence of biphasic cal-cium phosphate surfaces coated with enamel matrix derivative on vertical bone growth in an extra-oral rabbit model[J]. Clin Oral Implants Res, 2016,27(10):1297-1304.
doi: 10.1111/clr.2016.27.issue-10
[13] Eickholz P, Röllke L, Schacher B , et al. Enamel matrix derivative in propylene glycol alginate for treatment of infrabony defects with or without sys-temic doxycycline: 12- and 24-month results[J]. J Periodontol, 2014,85(5):669-675.
doi: 10.1902/jop.2013.130290
[14] Mrozik KM, Gronthos S, Menicanin D , et al. Effect of coating straumann bone ceramic with emdogain on mesenchymal stromal cell hard tissue forma-tion[J]. Clin Oral Investig, 2012,16(3):867-878.
doi: 10.1007/s00784-011-0558-3
[15] John V, De Poi R, Blanchard S , Socket preservation as a precursor of future implant placement: review of the literature and case reports[J]. Compend Contin Educ Dent, 2007,28(12):646-654, 671.
[16] Alkan EA, Tüter G, Parlar A , et al. Evaluation of peri-implant crevicular fluid prostaglandin E2 levels in augmented extraction sockets by different bioma-terials[J]. Acta Odontol Scand, 2016,74(7):532-538.
doi: 10.1080/00016357.2016.1214979
[17] Favato MN, Vidigal BC, Cosso MG , et al. Impact of human maxillary sinus volume on grafts dimensional changes used in maxillary sinus augmentation: a mul-tislice tomographic study[J]. Clin Oral Implants Res, 2015,26(12):1450-1455.
doi: 10.1111/clr.12488
[18] Simion M, Ferrantino L, Idotta E , et al. The associa-tion of guided bone regeneration and enamel matrix derivative for suprabony reconstruction in the es-thetic area: a case report[J]. Int J Periodontics Resto-rative Dent, 2015,35(6):767-772.
doi: 10.11607/prd.2297
[19] El Helow K , El Askary Ael S. Regenerative barriers in immediate implant placement: a literature review[J]. Implant Dent, 2008,17(3):360-371.
doi: 10.1097/ID.0b013e3181813406 pmid: 18784536
[20] Cangini F, Cornelini R , A comparison between enamel matrix derivative and a bioabsorbable membrane to enhance healing around transmucosal immediate post-extraction implants[J]. J Periodontol, 2005,76(10):1785-1792.
doi: 10.1902/jop.2005.76.10.1785
[21] Lim HC, Lee JS, Jung UW , et al. Bone regenerative potential of enamel matrix protein in the circumfe-rential defect around a dental implant[J]. Implant Dent, 2016,25(2):179-185.
doi: 10.1097/ID.0000000000000383
[22] Franke Stenport V, Johansson CB , Enamel matrix derivative and titanium implants[J]. J Clin Periodon-tol, 2003,30(4):359-363.
doi: 10.1034/j.1600-051X.2003.00326.x
[23] Murai M, Sato S, Koshi R , et al. Effects of the enamel matrix derivative and beta-tricalcium phosphate on bone augmentation within a titanium cap in rabbit calvarium[J]. J Oral Sci, 2005,47(4):209-217.
doi: 10.2334/josnusd.47.209
[24] 黎卫星, 姜玲, 张晓燕 , 等. 种植体周围软组织状态对种植义齿修复的影响[J]. 医学研究生学报, 2011,24(4):420-422.
Li WX, Jiang L, Zhang XY , et al. Influence of the peri-implant soft tissue state to the implant supported denture restoration[J]. J Med Postgra, 2011,24(4):420-422.
[25] Bates C, Marino V, Fazzalari NL , et al. Soft tissue attachment to titanium implants coated with growth factors[J]. Clin Implant Dent Relat Res, 2013,15(1):53-63.
doi: 10.1111/j.1708-8208.2010.00327.x pmid: 21435158
[26] Wang Y, Zhang Y, Jing D , et al. Enamel matrix de-rivative improves gingival fibroblast cell behavior cultured on titanium surfaces[J]. Clin Oral Investig, 2016,20(4):685-695.
doi: 10.1007/s00784-015-1558-5
[27] Guimarães GF, de Araújo VC, Nery JC , et al. Mi-crovessel density evaluation of the effect of enamel matrix derivative on soft tissue after implant place-ment: a preliminary study[J]. Int J Periodontics Restorative Dent, 2015,35(5):733-738.
[28] Schwarz F, Rothamel D, Herten M , et al. Effect of enamel matrix protein derivative on the attachment, proliferation, and viability of human SaOs2 osteo-blasts on titanium implants[J]. Clin Oral Investig, 2004,8(3):165-171.
[29] Lang NP, Berglundh T , Working Group 4 of Seventh European Workshop on Periodontology. Periimplant diseases: where are we now? Consensus of the seventh european workshop on periodontology[J]. J Clin Periodontol, 2011,38(Suppl 11):178-181.
doi: 10.1111/jcpe.2011.38.issue-s11
[30] Lindhe J, Meyle J , Group D of European Workshop on Periodontology. Peri-implant diseases: consensus report of the sixth european workshop on perio-dontology[J]. J Clin Periodontol, 2008,35(8 Suppl):282-285.
doi: 10.1111/cpe.2008.35.issue-s8
[31] Kashefimehr A, Pourabbas R, Faramarzi M , et al. Effects of enamel matrix derivative on non-surgical management of peri-implant mucositis: a double-blind randomized clinical trial[J]. Clin Oral Investig, 2017,21(7):2379-2388.
doi: 10.1007/s00784-016-2033-7
[32] Faramarzi M, Goharfar Z, Pourabbas R , et al. Micro-biological and clinical effects of enamel matrix de-rivative and sustained-release micro-spherical mino-cycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation[J]. J Korean Assoc Oral Maxillofac Surg, 2015,41(4):181-189.
doi: 10.5125/jkaoms.2015.41.4.181
[33] Froum SJ, Froum SH, Rosen PS , Successful manage-ment of peri-implantitis with a regenerative approach: a consecutive series of 51 treated implants with 3- to 7.5-year follow-up[J]. Int J Periodontics Restorative Dent, 2012,32(1):11-20.
[34] Isehed C, Holmlund A, Renvert S , et al. Effectiveness of enamel matrix derivative on the clinical and micro-biological outcomes following surgical regenerative treatment of peri-implantitis. A randomized con-trolled trial[J]. J Clin Periodontol, 2016,43(10):863-873.
doi: 10.1111/jcpe.2016.43.issue-10
[35] Froum SJ, Froum SH, Rosen PS , A regenerative approach to the successful treatment of peri-im-plantitis: a consecutive series of 170 implants in 100 patients with 2- to 10-year follow-up[J]. Int J Perio-dontics Restorative Dent, 2015,35(6):857-863.
doi: 10.11607/prd.2571
[1] 廖洪林,方仲瀚,张艳艳,刘飞,沈颉飞. 牙种植术后三叉神经创伤性神经病理性疼痛的诊断与防治[J]. 国际口腔医学杂志, 2023, 50(6): 729-738.
[2] 刘云通,刘畅,高丽钞,罗瑜雪,曹钰彬,华成舸. 术后下牙槽神经功能障碍的研究进展[J]. 国际口腔医学杂志, 2023, 50(4): 479-484.
[3] 李沛然,毕瑞野,王旻,王瑞宇,刘尧,姜楠,曹品银,祝颂松. 上颌Le Fort Ⅰ前徙术与前份根尖下截骨后退术术后软组织变化的比较研究[J]. 国际口腔医学杂志, 2023, 50(3): 293-301.
[4] 陆倩,夏海斌,王敏. 种植体磨光整形术治疗种植体周围炎的研究进展[J]. 国际口腔医学杂志, 2023, 50(2): 152-158.
[5] 樊永杰,董婷婷. 内蒙古地区蒙古族和汉族成人面部软组织侧貌角度对比研究[J]. 国际口腔医学杂志, 2022, 49(6): 648-656.
[6] 曹正国. 修复治疗相关的牙周问题考量[J]. 国际口腔医学杂志, 2022, 49(1): 1-11.
[7] 李媛媛,陈俊宇,蔡和,万乾炳. 甲状旁腺激素及甲状旁腺素相关肽在牙齿硬组织形成中的作用[J]. 国际口腔医学杂志, 2021, 48(6): 703-710.
[8] 王悦,文冰,邓梦婷,李建平. 低能量激光治疗对种植体周围组织愈合的研究进展[J]. 国际口腔医学杂志, 2021, 48(6): 725-730.
[9] 吴洁林,高莺. 硬腭获取游离软组织移植物的应用进展[J]. 国际口腔医学杂志, 2020, 47(6): 686-692.
[10] SupriyaShakya,张鑫,王剑. 种植盾构术的研究进展[J]. 国际口腔医学杂志, 2020, 47(1): 109-114.
[11] 于婉琦,周延民,赵静辉. 口腔种植体新材料的研究现状[J]. 国际口腔医学杂志, 2019, 46(4): 488-496.
[12] 王美洁,谭欣,赵雨薇,于海洋. 即刻种植和传统种植对术后疼痛影响的对比研究[J]. 国际口腔医学杂志, 2019, 46(3): 292-296.
[13] 房方方,常雅琴,董迎春,秦莎莎,陈斌. 异种胶原蛋白基质与自体结缔组织移植瓣牙周软组织增量效果的系统评价与Meta分析[J]. 国际口腔医学杂志, 2019, 46(2): 135-141.
[14] 曹焜,李家锋,孙玉华,鲍强,卢秋宁,唐巍. 下颌下窝的锥形束CT影像分析[J]. 国际口腔医学杂志, 2019, 46(2): 209-212.
[15] 刘玲玲,刘树泰. 上颌腭侧软组织厚度的测量方法及影响因素[J]. 国际口腔医学杂志, 2019, 46(2): 234-237.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 王昆润. 二甲亚砜和双氯芬酸并用治疗根尖周炎[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 汤庆奋,王学侠. 17β-雌二醇对人类阴道和口腔颊粘膜的渗透性[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 潘劲松. 颈总动脉指压和颈内动脉球囊阻断试验在大脑血液动力学中的不同影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 王昆润. 后牙冠根斜形牙折的治疗[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 杨锦波. 嵌合体防龋疫苗的研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 王昆润. 下颔骨成形术用网状钛板固定植骨块[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 汪月月,郭莉莉. 口腔机能与老化—痴呆危险因素流行病学研究[J]. 国际口腔医学杂志, 1999, 26(04): .
[8] 丁刚. 应用硬组织代用品种植体行丰颏术[J]. 国际口腔医学杂志, 1999, 26(04): .
[9] 田磊. 局部应用脂多糖后结合上皮反应性增生的变化[J]. 国际口腔医学杂志, 1999, 26(04): .
[10] 戴青. 口腔念珠菌病的新分类[J]. 国际口腔医学杂志, 1999, 26(04): .