国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (2): 168-171.doi: 10.7518/gjkq.2016.02.012

• 综述 • 上一篇    下一篇

骨膜蛋白及其在牙周膜中的生物学作用

吴自强,汤春波   

  1. 南京医科大学口腔疾病研究江苏省重点实验室,南京医科大学附属口腔医院种植修复科 南京 210029
  • 收稿日期:2015-09-12 修回日期:2015-12-19 出版日期:2016-03-01 发布日期:2016-03-01
  • 通讯作者: 汤春波,主任医师,博士,Email:cbtang@njmu.edu.cn
  • 作者简介:吴自强,硕士,Email:nicole_wuzq@163.com

Periostin and its biological function in periodontal ligament

Wu Ziqiang, Tang Chunbo   

  1. Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University; Dept. of Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China)
  • Received:2015-09-12 Revised:2015-12-19 Online:2016-03-01 Published:2016-03-01

摘要: 骨膜蛋白是一种细胞基质蛋白,是在鼠成骨细胞中发现的一种具有细胞黏附作用的蛋白质,其为细胞外基质功能完整的重要组成部分;骨膜蛋白表达于胚胎发育阶段和成年机体的多种组织中,如骨、心脏、肺、动静脉及牙周膜等。诸多研究揭示了骨膜蛋白参与维持牙周膜细胞功能及调节牙周膜胶原纤维形成过程,能够促进牙周膜细胞黏附、增殖、分化,促进牙周膜细胞成牙周膜样和成牙骨质样作用;在牙周膜胶原纤维形成过程中,骨膜蛋白可和胶原共存,在机械应力刺激下,可维持牙周膜纤维系统完整性。本文基于骨膜蛋白的发现和表达,对骨膜蛋白参与牙周膜生物学功能维持的研究进展作一综述。

关键词: 骨膜蛋白, 细胞基质蛋白, 牙周膜, 牙周膜细胞, 骨膜蛋白, 细胞基质蛋白, 牙周膜, 牙周膜细胞

Abstract: Periostin, a matricellular protein first found in rat osteoblast with cell adhesion function, is essential for the function maintenance of extracellular matrix and is expressed in various stages of embryonic development and various adult tissues, such as bone, heart, lung, artery, vein, and periodontal ligament. The function of periostinin cardiovascular physiology or occurrence and development of tumor has been fully studied. The function of periostin in human periodontal ligament cells and tooth development has gained much interest. Many studies have revealed that periostin plays multiple functions in periodontal ligament formation as well as in human periodontal ligament cell recruitment, adhesion, and differentiation and plays a key role in the remodeling of the periodontal ligament. The formation of collagen fiber is a complicated process, with multiple matricellular proteins involved. Periostin interacts with collagen and can maintain the integrity of periodontal ligament under mechanical stress. The present article reviews the development of periostin research on periodontal ligament function maintenance.

Key words: periostin, matricellular proteins, periodontal ligament, periodontal ligament cells, periostin, matricellular proteins, periodontal ligament, periodontal ligament cells

中图分类号: 

  • R 782
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