Int J Stomatol

Inter J Stomatol ›› 2009, Vol. 36 ›› Issue (4): 455-458.doi: 10.3969/j.issn.1673-5749.2009.04.024

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Application of cobalt chloride in cell hypoxia in vitro research

QUAN Jing-jing, LING Jun-qi   

  1. Research Institute of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen Un
  • Received:2008-11-20 Revised:2009-03-23 Online:2009-07-20 Published:2009-07-20
  • Contact: LING Jun-qi

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Abstract: Cobalt chloride, a hypoxia-mimicking agent, is widely used in the research of cell proliferation, differentiation and various hypoxic responses. The pulpal inflammation could result in hypoxia and subsequent pulp damage, and these studies on cobalt chloride may provide new methods to induce dental pulp cells hypoxia in vitro.

Key words: cobalt chloride, hypoxia, hypoxia induced factor


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