Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (6): 786-789.doi: 10.3969/j.issn.1673-5749.2012.06.022

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Research progress on the regulation of spx protein

Zhao Wei, Yu Danni.   

  1. Dept. of Stomatology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • Received:2012-05-05 Revised:2012-08-14 Online:2012-11-01 Published:2012-11-01

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Abstract:

Streptococus mutans is known as a primary pathogen of dental caries, which experiences all kinds of pressure changes in oral cavity, and its pathogenicity closely relates to the tolerance in a variety of environments. The spx protein is a global regulator in Gram-positive bacteria, and plays a particular role in stress tolerance, survival and virulence of Streptococus mutans. This article reviewed the spx protein, the structure of spx/α-C terminal domain complex and the regulation of spx protein in Streptococus mutans and non-cariogenic bacterias.

Key words: Streptococus mutans, spx protein, stress tolerance, virulence


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