Inter J Stomatol ›› 2017, Vol. 44 ›› Issue (6): 707-711.doi: 10.7518/gjkq.2017.06.016

• Reviews • Previous Articles     Next Articles

Clinical application of botulinum toxin type A in oral and maxillofacial region

She Yangyang, Nong Xiaolin.   

  1. Dept. of Oral and Maxillofacial Surgery, College and Hospital of Stomatology, Guangxi Medical University, Nanning 530021, China
  • Received:2017-02-06 Revised:2017-05-03 Online:2017-11-01 Published:2017-11-01
  • Supported by:
    This study was supported by Scientific Research and Technology Development Project of Guangxi(14123006-2) and Innovation Project of Guangxi Graduate Education(201010598RY10).

Abstract: Botulinum toxin type A(BTX-A) is a kind of exotoxin produced by the bacterium Clostridium botulinum which works by inhibiting the release of acetylcholine at the neuromuscular junction. Recent studies have found that BTX-A can be used in the oral and maxillofacial plastic surgery and the treatment of some oral diseases, providing a new method and a new direction for alternative treatment of oral diseases. The present review focuses on the mechanism, clinical application in the oral and maxillofacial region, operation cautions, contraindications and treatment of BTX-A.

Key words: botulinum toxin type A, oral and maxillofacial region, clinical application

CLC Number: 

  • R782

TrendMD: 
[1] Lam SM. The basic science of botulinum toxin[J]. Fa-cial Plast Surg Clin North Am, 2003, 11(4):431-438.
[2] Niamtu J. Botulinum toxin A: a review of 1 085 oral and maxillofacial patient treatments[J]. J Oral Maxi-llofac Surg, 2003, 61(3):317-324.
[3] Jaspers GW, Pijpe J, Jansma J. The use of botulinum toxin type A in cosmetic facial procedures[J]. Int J Oral Maxillofac Surg, 2011, 40(2):127-133.
[4] Semchyshyn N, Sengelmann RD. Botulinum toxin A treatment of perioral rhytides[J]. Dermatol Surg, 2003, 29(5):490-495.
[5] Suber JS, Dinh TP, Prince MD, et al. Onabotulinum-toxinA for the treatment of a “gummy smile”[J]. Aesthet Surg J, 2014, 34(3):432-437.
[6] Hwang WS, Hur MS, Hu KS, et al. Surface anatomy of the lip elevator muscles for the treatment of gum-my smile using botulinum toxin[J]. Angle Orthod, 2009, 79(1):70-77.
[7] Chang CS, Wallace CG, Hsiao YC, et al. Botulinum toxin to improve results in cleft lip repair[J]. Plast Reconstr Surg, 2014, 134(3):511-516.
[8] Shaarawy E, Hegazy RA, Abdel Hay RM. Intralesio-nal botulinum toxin type A equally effective and bet-ter tolerated than intralesional steroid in the treat-ment of keloids: a randomized controlled trial[J]. J Cosmet Dermatol, 2015, 14(2):161-166.
[9] Lee SH, Wee SH, Kim HJ, et al. Abobotulinum toxin A and onabotulinum toxin A for masseteric hyper-trophy: a split-face study in 25 Korean patients[J]. J Dermatolog Treat, 2013, 24(2):133-136.
[10] Wei J, Xu H, Dong J, et al. Prolonging the duration of masseter muscle reduction by adjusting the masti-catory movements after the treatment of masseter mus-cle hypertrophy with botulinum toxin type a injection [J]. Dermatol Surg, 2015, 41(Suppl 1):S101-S109.
[11] Bae JH, Choi DY, Lee JG, et al. The risorius muscle: anatomic considerations with reference to botulinum neurotoxin injection for masseteric hypertrophy[J]. Dermatol Surg, 2014, 40(12):1334-1339.
[12] Qian W, Zhang YK, Lv W, et al. Application of local injection of botulinum toxin A in cosmetic patients with congenital drooping mouth corner[J]. Aesthetic Plast Surg, 2016, 40(6):926-930.
[13] Pihut M, Ferendiuk E, Szewczyk M, et al. The effi-ciency of botulinum toxin type A for the treatment of masseter muscle pain in patients with temporoman-dibular joint dysfunction and tension-type headache [J]. J Headache Pain, 2016, 17(1):29.
[14] Ernberg M, Hedenberg-Magnusson B, List T, et al. Efficacy of botulinum toxin type A for treatment of persistent myofascial TMD pain: a randomized, con-trolled, double-blind multicenter study[J]. Pain, 2011, 152(9):1988-1996.
[15] Stark TR, Perez CV, Okeson JP. Recurrent TMJ dis-location managed with botulinum toxin type a injec-tions in a pediatric patient[J]. Pediatr Dent, 2015, 37 (1):65-69.
[16] Oztel M, Bilski WM, Bilski A. Botulinum toxin used to treat recurrent dislocation of the temporomandibular joint in a patient with osteoporosis[J]. Br J Oral Maxi-llofac Surg, 2017, 55(1):e1-e2.
[17] Zhang H, Lian Y, Ma Y, et al. Two doses of botu-linum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind, placebo-controlledtrial [J]. J Headache Pain, 2014, 15(1):65.
[18] Al-Wayli H. Treatment of chronic pain associated with nocturnal bruxism with botulinum toxin. A prospective and randomized clinical study[J]. J Clin Exp Dent, 2017, 9(1):e112-e117.
[19] Barbero P, Busso M, Artusi CA, et al. Ultrasound-guided botulinum toxin-A injections: a method of treating sialorrhea[J]. J Vis Exp, 2016(117). doi:10.3791/54606.
[20] Sorgun MH, Yilmaz R, Akin YA, et al. Botulinum toxin injections for the treatment of hemifacial spasm over 16 years[J]. J Clin Neurosci, 2015, 22(8):1319-1325.
[21] Li YJ, Huang Y, Ding Q, et al. Evaluation of concen-trations of botulinum toxin A for the treatment of hemifacial spasm: a randomized double-blind cross-over trial[J]. Genet Mol Res, 2015, 14(1):1136-1144.
[22] Alexoudi A, Dalivigka Z, Siatouni A, et al. Oroman-dibular dystonia: a case report of the lateral pterygoid muscle involvement and treatment with botulinum toxin a[J]. Clin Pract, 2016, 6(3):862.
[23] Melville JC, Stackowicz DJ, Jundt JS, et al. Use of Botox(OnabotulinumtoxinA) for the treatment of parotid sialocele and fistula after extirpation of buccal squamous cell carcinoma with immediate reconstruc-tion using microvascular free flap: a report of 3 cases [J]. J Oral Maxillofac Surg, 2016, 74(8):1678-1686.
[24] Kayikçioğlu A, Erk Y, Mavili E, et al. Botulinum toxin in the treatment of zygomatic fractures[J]. Plast Reconstr Surg, 2003, 111(1):341-346.
[25] Akbay E, Cevik C, Damlar I, et al. Treatment of displaced mandibular condylar fracture with botuli-num toxin A[J]. Auris Nasus Larynx, 2014, 41(2): 219-221.
[1] Wu Jiaxin,Cheng Xingqun,Wu Hongkun.. Clinical application and research progress on hyaluronic acid in the repair of papillary height loss [J]. Int J Stomatol, 2023, 50(3): 347-352.
[2] Liu Lin,Zhou Jieyu,Wu Yafei,Zhao Lei. Application of probiotic ecological regulation in prevention and treatment of periodontal diseases [J]. Int J Stomatol, 2020, 47(2): 131-137.
[3] Zhulin Hu,Yi Zhao,Yin Li. Analysis status and clinical application prospect of biomarkers in oral gingival crevicular fluid [J]. Int J Stomatol, 2019, 46(3): 308-315.
[4] Ding Jie, Song Guangtai.. Clinical application of minimally invasive techniques in the management of children’s dental caries [J]. Inter J Stomatol, 2018, 45(4): 473-479.
[5] Zheng Wei, Li Yu. New development in the comprehensive multidisciplinary treatment of gummy smile [J]. Inter J Stomatol, 2017, 44(5): 509-513.
[6] Li Xiao, Ji Tong.. Chemotherapy in the treatment of osteosarcoma in oral maxillofacial-head and neck region [J]. Inter J Stomatol, 2017, 44(1): 83-86.
[7] Guo Wenhao, You Meng, Luo Jingjing, Wang Kaili, Wang Hu, Zheng Guangning. Four cases of X-ray and cone beam computed tomography radiographic findings of non-Hodgkin’s lymphoma involving jaws in the oral and maxillofacial region [J]. Inter J Stomatol, 2016, 43(2): 146-150.
[8] Wu Xingchen, Zhu Yaqin. Characteristics and evaluation of the clinical application of a self-adjusting file [J]. Inter J Stomatol, 2013, 40(6): 764-768.
[9] Yu Tingting, Song Guangbao.. Characteristics and clinical application of the T -Scan system [J]. Inter J Stomatol, 2013, 40(1): 113-116.
[10] Bian Xiang1, Li Zhiren2, Yang Yongjin2, Shen Huan2.. Clinical treatment based on Bolton analysis [J]. Inter J Stomatol, 2012, 39(5): 646-648.
[11] CHEN Bing. Clinical application of easy resilient attachment denture [J]. Inter J Stomatol, 2010, 37(3): 265-265~267.
[12] GU Min, GU Wei-ping. Clinical application of gingival retraction technology [J]. Inter J Stomatol, 2010, 37(3): 344-344~347.
[13] CHENG Shi-bing, XIE Hui-xu, LI Long-jiang.. Research progress of clinical application of thermochemotherapy of tumor [J]. Inter J Stomatol, 2010, 37(3): 337-337~340.
[14] ZHANG Ying-juan, CHEN Wen-xia. Plasticity of dental pulp stem cell [J]. Inter J Stomatol, 2009, 36(5): 554-556.
[15] WANG Xiao-rong, CHEN Jianghao, NIU Yi-rui. Clinical application of miniscrew implants used as orthodontic anchorage [J]. Inter J Stomatol, 2009, 36(5): 537-539,543.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .