Int J Stomatol

Inter J Stomatol ›› 2015, Vol. 42 ›› Issue (2): 243-247.doi: 10.7518/gjkq.2015.02.028

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Effects of β-catenin and its role in the occurrence of palate

Pang Xiaoxiao, Li Chenghao, Shi Bing   

  1. State Key Laboratory of Oral Diseases, Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2014-02-26 Revised:2014-09-19 Online:2015-03-01 Published:2015-03-01

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Abstract:

Palate is caused by various genes that regulate morphogenesis, and any abnormal regulation may lead to cleft palate. A large number of palatogenesis genes and related cytokines have been found; in these genes, beta catenin and wingless-type mouse breast tumor virus integration site family(WNT) interact to form the WNT/β-catenin signaling pathway. This pathway widely participates in the occurrence of palates. The formation, migration, and differentiation of WNT/β-catenin are closely related to those of neural crest cells. The WNT/β-catenin signaling regulates the processes involved in growth, development of head and facial skeletal muscles, adjustment of palate fusion, and regulation of palatal wrinkle formation. This paper summarized and reviewed the role of beta catenin on palatogenesis.

Key words: cleft palate, palatogenesis, β-catenin


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