Int J Stomatol

Inter J Stomatol ›› 2014, Vol. 41 ›› Issue (2): 209-212.doi: 10.7518/gjkq.2014.02.023

Previous Articles     Next Articles

Biological function and application prospects of cementum protein 1

Ou Wei1, Sun Weibin2.   

  1. 1. Dept. of Stomatology, Deyang People’s Hospital, Deyang 618000, China; 2. Dept. of Periodontics, Nanjing Stomatological Hospital of Medical School, Nanjing University, Nanjing 210008, China
  • Received:2013-08-18 Revised:2013-12-16 Online:2014-03-01 Published:2014-03-01

RichHTML

6

PDF (PC)

681

Abstract:

Cementum protein(CEMP)1, a specific product expressed during cementum formation, is an alkaline protein with a relative molecular mass of 2.59×104. The secondary structure present in recombinant human CEMP1(rhCEMP1) is mainly composed of β-sheet. Transfection of CEMP1 into human gingival fibroblasts promotes calcium nodule formation of hydroxyapatite that resembles the biological type, in Ca/P, which indicates cemetoblast and osteoblast phenotypes. CEMP1 can regulate core binding factor α1, a transcriptional activator of osteoblast differentiation. Co-culturing rhCEMP1 with human periodontal ligament cell (hPDLC) induces the formation of a tissue-like structure resembling bone and cementum, and cartilage-like material. Alkaline phosphatase(AKP)-positive hPDLC is preferentially categorized into cemetoblasts and osteoblasts. CEMP1 is strictly expressed in only a few hPDLC and >90% of cemetoblasts. Therefore, CEMP1 is closely related to the high AKP concentration in hPDLC. This article reviews the research progress in the biological function and future applications of CEMP1.

Key words: cementum protein, biomineralization, cell differentiation

CLC Number: 

  • Q 51

TrendMD: 
[1] Yuxuan Yang,Haixia Zhang,Shuang Wang. Biological function of amelogenin during periodontal regeneration [J]. Inter J Stomatol, 2019, 46(2): 191-196.
[2] Wu Yunshu, Yuan Quan. Regulation of RNA N6-methylation of adenosine on stem cell differentiation [J]. Inter J Stomatol, 2018, 45(3): 272-275.
[3] Xu Xin, Wang Yanmin,Bai Ding. Silent mating type information regulation 2 homolog 1 in bone and cartilage homeostasis [J]. Inter J Stomatol, 2016, 43(5): 569-572.
[4] Qiu Jingyi, Wan Lingyun, Zhao Zhihe, Li Juan. Regulation of external and internal forces on the chondrogenic differentiation of mesenchymal stem cells [J]. Inter J Stomatol, 2016, 43(4): 449-455.
[5] Pan Youtiao, Wang Yifei, Zhao Xun, Zeng Xianzhuo, Zhang Zhen, Cheng Junjun, Li Xianing, Liu Wei, Zhao Hongyu. Inhibition and induction on the differentiation of periodontal ligament stem cells in different microenvironments [J]. Inter J Stomatol, 2016, 43(2): 207-211.
[6] HUO Yong-biao, LING Jun-qi.. Research progress on banking stem cells from human exfoliated deciduous teeth [J]. Inter J Stomatol, 2011, 38(2): 188-191.
[7] ZHOU Haihua, LI Zu-bing. Molecular regulation mechanism of Nel-like type 1 molecule to the osteoblast diff [J]. Inter J Stomatol, 2010, 37(02): 166-166～169.
[8] MAI Jun-ni, CHEN Chan -chan, LING Jun -qi. Research progress on Matrilin family [J]. Inter J Stomatol, 2009, 36(6): 691-693，697.
[9] LIU Dong-mei1, DONG Fu-sheng2. Dentin matrix protein-1 and biomineralization [J]. Inter J Stomatol, 2009, 36(1): 98-98～101.
[10] CHENG Lei, ZHOU Xue-dong. The mechanism of osteoproteger in on miner alization of enamel [J]. Inter J Stomatol, 2008, 35(2): 116-118.
[11] FU Zhong- sen, ZHU Yu- ting, HU Tao. Research progress of odontoblast's specific molecular markers [J]. Inter J Stomatol, 2008, 35(2): 155-157.
[12] WEI Xi, LIU Lu, LING Jun-qi.. Research progress of matrix extracellular phosphoglycoprotein [J]. Inter J Stomatol, 2007, 34(04): 259-261.
[13] WU Li-ping, LING Jun-qi.. Molecular Biology Basis of Maintaining Per iodontal Ligament Structur e and Functional Homeostasis [J]. Inter J Stomatol, 2007, 34(02): 87-89.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[10] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .