Inter J Stomatol
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HU Yan1, Camile S. Farah2, Robert B. Ashman2
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Abstract: The cell- mediated immune（CMI）response involves a complex series of events after antigens enter the body. First, the antigen must be taken up by macrophages or/and dendritic cells and presented to T cells, which become activated as T- helper（CD4 cells） or cytotoxic T cells（CD8 cells）. CD4 cells are classified into two subgroups: Th1 cells, that secrete predominantly interleukin（IL）- 2 and interferon- γ; and Th2 cells, that secrete predominantlyIL- 4, IL- 5, and IL- 10. These cytokine secretion profiles distinguish the so- called Th1 or Th2 responses to antigen stimulation. Th1 responses activate neutrophils and macrophages to a candidacidal activity, whereas Th2responses tend to inhibit a fungicidal state in Candida infection. There is general consensus that CMI is essential for the protection of mucosal tissues from Candida infection although the function of T cells in systemic candidiasisremains contentious.
HU Yan1, Camile S. Farah2, Robert B. Ashman2. Role of cell - mediated immunity in mur ine r esponses to Candida infection
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https://www.gjkqyxzz.cn/EN/Y2008/V35/I4/411
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