Int J Stomatol

Int J Stomatol ›› 2026, Vol. 53 ›› Issue (1): 91-97.doi: 10.7518/gjkq.2026107

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Research progress on cuproptosis in periodontitis

Qiqi Shi(),Xu Qin,Guangxun Zhu()   

  1. Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology & School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology & Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430030, China
  • Received:2024-10-12 Revised:2025-07-18 Online:2026-01-01 Published:2025-12-31
  • Contact: Guangxun Zhu E-mail:2657785772@qq.com;zhuguangxun@163.com
  • Supported by:
    National Natural Science Foundation of China(81800981);Natural Science Foundation of Hubei Pro-vince of China(2023AFB653)

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Abstract:

Periodontitis is an immune-inflammatory response triggered by periodontal pathogens. In this condition, disrupted immune responses and chronic inflammation play crucial roles in the degradation of periodontal tissues. Cuproptosis, a recently identified form of programmed cell death, is triggered by excessive intracellular copper ions and specifically targets the tricarboxylic acid cycle. It is characterized by the abnormal oligomerization of mitochondrial lipoacylated proteins and the loss of iron-sulfur cluster proteins. Cuproptosis has garnered significant attention for its nonnegligible role in the development and progression of various diseases, including cardiovascular diseases, neurodegenerative disorders, and cancers. Cuproptosis-related genes participate in the pathogenesis of periodontitis by modulating immune cells and cytokines. The abnormal expression of these genes reflects the disease status and aids in clinical diagnosis, providing novel therapeutic targets for periodontitis treatment. Considering these insights, this work presents a comprehensive review of the molecular mechanisms underlying cuproptosis and its role in the initiation and progression of periodontitis.

Key words: cuproptosis, periodontitis, cuproptosis-related genes

CLC Number: 

  • R781.4

TrendMD: 
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