Int J Stomatol

Int J Stomatol ›› 2025, Vol. 52 ›› Issue (5): 662-669.doi: 10.7518/gjkq.2025085

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Advancements in prevention and treatment strategies for orthodontically induced root resorption

Yi Liu(),Bowen Zheng,Yi Liu()   

  1. Dept. of Orthodontics, School and Hospital of Stomatology, China Medical University, Shenyang Clinical Medical Research Center of Orthodontic Disease, Shenyang 110002, China
  • Received:2024-08-02 Revised:2024-12-02 Online:2025-09-01 Published:2025-08-27
  • Contact: Yi Liu E-mail:yliu@cmu.edu.cn;liuyi@cmu.edu.cn
  • Supported by:
    Basic Scientific Research Project of Education Department of Liaoning Province(LJKMZ20221190)

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Abstract:

Orthodontically induced inflammatory root resorption (OIRR) is one of the most common iatrogenic complications associated with clinical orthodontic treatment, potentially compromising therapeutic outcomes and threatening tooth life. In recent years, various novel strategies have been proposed to mitigate OIRR by enhancing root repair, promo-ting cementum mineralization and minimizing periodontal damage. These emerging approaches aim to modulate cementum metabolism and the microenvironment under mechanical stress through in vitro and in vivo studies. Strategies include the application of physical therapies, hormones, pharmacological agents, nanotechnology-based targeting systems, and stem cell-derived products. Stem cells and their secreted byproducts have shown promise as therapeutic candidates for facilitating cementum regeneration and revealing underlying mechanisms of root resorption repair. This review summarizes recent advancements in the prevention and treatment of OIRR, providing a comprehensive reference for clinical applications and future research directions.

Key words: orthodontics, orthodontically induced inflammatory root resorption, cementum, stem cell therapy

CLC Number: 

  • R783.5

TrendMD: 

Fig 1

Schematic diagram of factors/pathways associated with OIRR occurrence and repair"

Fig 2

Schematic diagram of OIRR prevention and treatment strategies mechanism"

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