Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (4): 505-512.doi: 10.7518/gjkq.2024057

• Reviews • Previous Articles    

Role of the small integrin-binding ligand N-linked glycoprotein family in regulating hard tissue development

Siwei Xu(),Hui Li,Lei Liu()   

  1. State Key Laboratory of Oral Disease & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Trauma and Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-12-04 Revised:2024-03-15 Online:2024-07-01 Published:2024-06-24
  • Contact: Lei Liu E-mail:drxusiwei@foxmail.com;drliulei@163.com
  • Supported by:
    Youth Science Fund Projects of National Natural Science Foundation of China(82100961)

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Abstract:

The development of hard tissue is a crucial aspect of organismic development. The small integrin-binding ligand N-linked glycoprotein family plays a pivotal role in regulating hard tissue development, including promoting the differentiation of stem cells into odontoblasts or osteoblasts and regulating the gene expression of these cells. Research showed that mutations in the genes encoding this protein family can lead to abnormal mineralization of hard tissue, resul-ting in diseases such as hypophosphatemic rickets and dentinogenesis imperfecta. In recent years, scholars have conducted in-depth research on this protein family involved in hard tissue development. These studies have revealed the main mole-cular regulatory mechanism of the protein family and deepened our understanding of its role and mechanism. This review summarizes the role and the associated molecular regulatory mechanisms of the small integrin-binding ligand N-linked glycoprotein family in regulating hard tissue development.

Key words: small integrin-binding ligand N-linked glycoprotein family, hard tissue, biomineralization

CLC Number: 

  • R394.1

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